A viral subunit immunogen for porcine transmissible gastroenteritis.

abstract：:An extract of the cactus plant Opuntia streptacantha inhibited intracellular virus replication and inactivated extracellular virus. Inhibition of virus replication also occurred following pre-infection treatment--a favourable finding in terms of in-vivo limitation of virus disease. There was inhibition of both DNA and...

journal_title：Antiviral research

authors： Ahmad A,Davies J,Randall S,Skinner GR

更新日期：1996-05-01 00:00:00

abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...

journal_title：Antiviral research

authors： Dapat C,Kondo H,Dapat IC,Baranovich T,Suzuki Y,Shobugawa Y,Saito K,Saito R,Suzuki H

更新日期：2013-09-01 00:00:00

abstract：:A recombinant baculovirus (vAc-gC1) was constructed that expresses the glycoprotein C (gC) gene of herpes simplex virus type 1 (HSV-1). When Sf9 cells were infected with this recombinant, a protein that was smaller in size than authentic HSV-1 gC was detected by Western blotting using anti-gC polyclonal antibody. The ...

journal_title：Antiviral research

authors： Ghiasi H,Kaiwar R,Nesburn AB,Wechsler SL

更新日期：1992-06-01 00:00:00

abstract：:Human cytomegalovirus terminase complex cleaves the concatemeric genomic viral DNA into unit lengths during genome packaging and particle assembly. Terminase complex ATPase and endonuclease activity is provided by the viral protein pUL89. pUL89 is an attractive drug target because its activities are required for infec...

journal_title：Antiviral research

authors： Wang Y,Tang J,Wang Z,Geraghty RJ

更新日期：2018-04-01 00:00:00

abstract：:The heterocycle, 4,6-dibenzamidopyrazolo[3,4-d]pyrimidine (DBAPP), inhibited cytopathology induced by human, mouse, and vervet monkey cytomegaloviruses (CMV) in vitro at 0.2 to 0.5 microM, but did not inhibit cell replication at less than or equal to 30 microM. Herpes simplex viruses were unaffected by the inhibitor. ...

journal_title：Antiviral research

authors： Smee DF,Bartlett ML,Alaghamandan HA,Jones MM,Revankar GR,Robins RK

更新日期：1990-01-01 00:00:00

abstract：:The human pathogen hepatitis C virus (HCV) is associated with chronic liver disease. The recent development of the cell culture infectious HCV (HCVcc) system has opened up avenues for detailed studies on the life cycle of the virus and its interaction with the host cell. Current methods to quantitate virus infectivity...

journal_title：Antiviral research

authors： Iro M,Witteveldt J,Angus AG,Woerz I,Kaul A,Bartenschlager R,Patel AH

更新日期：2009-08-01 00:00:00

abstract：:Each year, up to 10,000 cases of infections with the flavivirus tick-borne encephalitis (TBE) virus that affect the central nervous system are reported in Europe and Asia. Due to the potentially severe adverse effects of post-exposure prophylaxis with TBE virus hyperimmunoglobulin, TBE can currently only be treated sy...

journal_title：Antiviral research

authors： Achazi K,Patel P,Paliwal R,Radonić A,Niedrig M,Donoso-Mantke O

更新日期：2012-01-01 00:00:00

abstract：:The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of...

journal_title：Antiviral research

authors： Andrei G,Carter K,Janeba Z,Sampath A,Schang LM,Tarbet EB,Vere Hodge RA,Bray M,Esté JA

更新日期：2017-09-01 00:00:00

abstract：:The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. In this review, we discuss the current state of knowledge of animal models of MERS-CoV infection. Commonly used ...

journal_title：Antiviral research

authors： van Doremalen N,Munster VJ

更新日期：2015-10-01 00:00:00

abstract：:Rotavirus (RV) and norovirus (NoV) are the two most important causes of viral gastroenteritis. While vaccine remains an effective prophylactic strategy, development of other approaches, such as passive immunization to control and treat clinical infection and illness of these two pathogens, is necessary. Previously we ...

journal_title：Antiviral research

authors： Dai YC,Zhang XF,Tan M,Huang P,Lei W,Fang H,Zhong W,Jiang X

更新日期：2013-03-01 00:00:00

abstract：:The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...

journal_title：Antiviral research

authors： Alotte C,Martin A,Caldarelli SA,Di Giorgio A,Condom R,Zoulim F,Durantel D,Hantz O

更新日期：2008-12-01 00:00:00

abstract：:A series of four mannose(Man)-, three N-acetylglucosamine (GlcNAc)n-, ten N-acetylgalactosamine/galactose(GalNAc/Gal)-, one 5-acetylneuraminic acid (alpha-2,3-Gal/GalNAc)- and one 5-acetylneuroaminic acid(alpha-2,6-Gal/Gal-NAc)-specific plant agglutinins were evaluated for their antiviral activity in vitro. the mannos...

journal_title：Antiviral research

authors： Balzarini J,Neyts J,Schols D,Hosoya M,Van Damme E,Peumans W,De Clercq E

更新日期：1992-06-01 00:00:00

abstract：:The single tablet regimen of the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) tenofovir disoproxil fumarate (TDF), emtricitabine (FTC), and the non-nucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is approved for the treatment of HIV-1 infection in treatment-naïve adults. Previous...

journal_title：Antiviral research

authors： Kulkarni R,Feng JY,Miller MD,White KL

更新日期：2014-01-01 00:00:00

abstract：:DNA immunizations with the major structural protein VP1 of Coxsackie virus B3 (CVB3) have been previously found to protect BALB/c mice from lethal challenge. Here we report that the other CVB3 capsid proteins, VP2, VP3, and VP4, were less effective at preventing CVB3-caused disease. The application of pCMV/VP1 as a va...

journal_title：Antiviral research

authors： Henke A,Zell R,Stelzner A

更新日期：2001-01-01 00:00:00

abstract：:We isolated a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) from a laboratory strain, AD169, and analysed the mutant. Attempts were also made to identify directly the mutated gene. The 50% inhibitory concentration (IC50) of GCV for the mutant strain was five times higher than that of the wild-type strain. T...

journal_title：Antiviral research

authors： Faizi Khan R,Mori S,Eizuru Y,Kumura Ishii K,Minamishima Y

更新日期：1998-12-01 00:00:00

abstract：:Adult woodchucks (Marmota monax) chronically infected with woodchuck hepatitis virus (WHV) were treated orally with lamivudine (15 mg/kg per day) for 57 weeks. After 20 weeks of treatment a 2-3 log reduction in serum WHV DNA was detected. Serum titers of WHV then increased gradually, in the presence of lamivudine trea...

journal_title：Antiviral research

authors： Jacob JR,Korba BE,Cote PJ,Toshkov I,Delaney WE 4th,Gerin JL,Tennant BC

更新日期：2004-08-01 00:00:00

abstract：:The outbreak of severe acute respiratory syndrome (SARS) in 2003 was the first emergence of an important human pathogen in the 21st century. Responding to the epidemic provided clinicians with extensive experience in diagnosing and treating a novel respiratory viral disease. In this article, we review the experience o...

journal_title：Antiviral research

authors： Cheng VC,Chan JF,To KK,Yuen KY

更新日期：2013-11-01 00:00:00

abstract：:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for ca...

journal_title：Antiviral research

authors： Tuppurainen ES,Pearson CR,Bachanek-Bankowska K,Knowles NJ,Amareen S,Frost L,Henstock MR,Lamien CE,Diallo A,Mertens PP

更新日期：2014-09-01 00:00:00

abstract：:The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (GCV) showed concentration-dependent inhibitory properties from 0.05 to 3....

journal_title：Antiviral research

authors： Akuzawa K,Yamada R,Li Z,Li Y,Sadanari H,Matsubara K,Watanabe K,Koketsu M,Tuchida Y,Murayama T

更新日期：2011-09-01 00:00:00

abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

journal_title：Antiviral research

authors： Kariya M,Mori S,Eizuru Y

更新日期：2000-02-01 00:00:00

abstract：:Cellular immune responses (T cell responses) during hepatitis C virus (HCV) infection are significant factors for determining the outcome of infection. HCV adapts to host immune responses by inducing mutations in its genome at specific sites that are important for HLA processing/presentation. Moreover, HCV also adapts...

journal_title：Antiviral research

authors： Ikram A,Obaid A,Awan FM,Hanif R,Naz A,Paracha RZ,Ali A,Janjua HA

更新日期：2017-01-01 00:00:00

abstract：:End stage liver disease caused by chronic infection with the hepatitis C virus (HCV) is a leading indication for liver transplantation, yet outcomes are poor since the liver graft is rapidly re-infected by HCV. Antibodies against the essential HCV receptor CD81 have been shown to inhibit HCV cell entry in vitro and in...

journal_title：Antiviral research

authors： Deest M,Westhaus S,Steinmann E,Manns MP,von Hahn T,Ciesek S

更新日期：2014-01-01 00:00:00

abstract：:The chemically modified DNA, apurinic acid (APA), is cytotoxic for human lymphocytes at concentrations above 100 micrograms/ml. At low concentrations (0.05-1 micrograms/ml) APA acts as an inducer interferon gamma (IFN-gamma) in lymphocytes in vitro; the maximum interferon titer of 50 units/ml was reached at 0.4 microg...

journal_title：Antiviral research

authors： Müller WE,Sarin PS,Sun D,Rossol S,Voth R,Rottmann M,Hess G,Meyer zum Büschenfelde KH,Schröder HC

更新日期：1988-04-01 00:00:00

abstract：:The identification of more effective and less toxic foscarnet (PFA) analogs for antiviral therapy would be useful. We recently synthesized 1-O-octadecyl-sn-glycero-3-phosphonoformic acid (ODG-PFA) and noted a 93-fold increase in its anti-HCMV activity relative to PFA. In addition, the antiviral activity of ODG-PFA in ...

journal_title：Antiviral research

authors： Kini GD,Beadle JR,Xie H,Aldern KA,Richman DD,Hostetler KY

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

journal_title：Antiviral research

authors： Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

更新日期：2011-02-01 00:00:00

abstract：:The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme pyrophosphate binding site. Replication of rotavirus in MA104 cells using different u.o.i. was inhibit...

journal_title：Antiviral research

authors： Ríos M,Muñoz M,Spencer E

更新日期：1995-05-01 00:00:00

abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...

journal_title：Antiviral research

authors： Jiang Y,Liu S,Shen S,Guo H,Huang H,Wei W

更新日期：2020-04-01 00:00:00

abstract：:Our aim was to analyze the virological response to a combined antiretroviral therapy started after Maraviroc Clinical Test (MCT) in naïve HIV-infected patients. Forty-one patients were exposed to MCT, based on an 8-day MVC monotherapy. If undetectability or a viral load reduction >1 log10 HIV-RNA copies/ml was achieve...

journal_title：Antiviral research

authors： Genebat M,de Pablo-Bernal RS,Pulido I,Jiménez-Mejías ME,Martínez O,Pacheco YM,Raffi-El-Idrissi Benhia M,Abad MA,Ruiz-Mateos E,Leal M

更新日期：2015-09-01 00:00:00

abstract：:Influenza viruses, which can cross species barriers and adapt to new hosts, pose a constant potential threat to human health. The influenza pandemic of 2009 highlighted the rapidity with which an influenza virus can spread worldwide. Currently available antivirals have a number of limitations against influenza, and no...

journal_title：Antiviral research

authors： Ilyushina NA,Donnelly RP

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:This paper presents the public health rationale for multipurpose prevention technologies (MPTs) for sexual and reproductive health (SRH) based on regional trends in demographic and SRH indicators. It then distils important lessons gleaned from the introduction of contraceptive and reproductive health product...

journal_title：Antiviral research

authors： Brady M,Manning J

更新日期：2013-12-01 00:00:00