Abstract：
:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for cattle against lumpy skin disease virus (LSDV). In the Middle East and the Horn of Africa these vaccines have been associated with incomplete protection and adverse reactions in cattle post-vaccination. The present study confirms that the real identity of the commonly used Kenyan sheep and goat pox vaccine virus (KSGP) O-240 is not SPPV but is actually LSDV. The low level attenuation of this virus is likely to be not sufficient for safe use in cattle, causing clinical disease in vaccinated animals. In addition, Isiolo and Kedong goat pox strains, capable of infecting sheep, goats and cattle are identified for potential use as broad-spectrum vaccine candidates against all capripox diseases.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Tuppurainen ES,Pearson CR,Bachanek-Bankowska K,Knowles NJ,Amareen S,Frost L,Henstock MR,Lamien CE,Diallo A,Mertens PPdoi
10.1016/j.antiviral.2014.06.009subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1-6eissn
0166-3542issn
1872-9096pii
S0166-3542(14)00171-5journal_volume
109pub_type
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