Abstract：
:Several pyrophosphate analogues have been studied for their effects on avian myeloblastosis virus reverse transcriptase and on cellular DNA polymerase alpha. Examination of structure-activity relationships for these compounds revealed that two acidic groups connected by a short bridge were necessary, but not sufficient, for inhibition of the enzyme activities. Foscarnet sodium (trisodium phosphonoformate) was the most potent inhibitor of reverse transcriptase, giving non-competitive inhibition of reactions primed by (rA)n . (dT)12-18, (rC)n . (dG)12-18, (dC)n . (dG)12-18, and activated DNA. Carbonyldiphosphonate and 2-hydroxyphosphonoacetate also caused non-competitive inhibition patterns, whereas hypophosphate and imidodiphosphonate inhibited AMV reverse transcriptase in a competitive, non-linear manner. The reverse transcriptase reactions directed by (rA)n . (dT)12-18 and activated DNA were most affected by the non-competitive inhibitors. Hypophosphate and imidodiphosphonate inhibited preferentially reactions primed by (dC)n . (dG)12-18 and activated DNA. In all cases the (rC)n . (dG)12-18 directed reaction was the least affected.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Eriksson B,Stening G,Oberg Bdoi
10.1016/0166-3542(82)90028-6subject
Has Abstractpub_date
1982-05-01 00:00:00pages
81-95issue
1-2eissn
0166-3542issn
1872-9096pii
0166-3542(82)90028-6journal_volume
2pub_type
杂志文章abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00002-5
更新日期：2002-06-01 00:00:00
abstract：:Hepatitis C virus (HCV)-specific T cells are key factors in the outcome of acute HCV infection and in protective immunity. This review recapitulates the steps that immunologists have taken in the past 25years to dissect the role of T cell responses in HCV infection. It describes technical as well as disease-specific c...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2014.11.009
更新日期：2015-02-01 00:00:00
abstract：:Oligodeoxynucleotides (ODNs) composed entirely of deoxyguanosine and thymidine, but not specifically designed to act as antisense agents, were able to significantly inhibit herpes simplex virus growth in acute infection assay systems. The guanosine/thymidine (GT) ODNs which demonstrated this antiviral activity contain...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(94)00064-f
更新日期：1995-01-01 00:00:00
abstract：:Resveratrol (RV), a polyphenolic natural product present in many plants and fruits, exhibits anti-inflammatory, cardio-protective and anti-proliferative properties. Moreover, RV affects a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.09.003
更新日期：2012-11-01 00:00:00
abstract：:RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2014.01.021
更新日期：2014-04-01 00:00:00
abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(95)00989-2
更新日期：1996-11-01 00:00:00
abstract：:Cytomegalovirus (CMV) is one of the most common opportunistic infections after transplantation. To prevent CMV infections, universal prophylaxis and pre-emptive therapy with ganciclovir or its prodrug valganciclovir is applied. However, prolonged antiviral therapy may result in drug-resistance emergence. We describe a...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.06.004
更新日期：2019-08-01 00:00:00
abstract：:The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.06.011
更新日期：2008-12-01 00:00:00
abstract：:Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(95)00047-p
更新日期：1995-10-01 00:00:00
abstract：:The reverse transcriptase (RT) of HIV which has been inhibited by the incorporation of AZT into the primer strand is subject to a deblocking reaction by cellular ATP. This reaction yields unblocked primer plus the dinucleoside tetraphosphate, AZTp(4)A. In the present study, we report that AZTp(4)A is an excellent subs...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(03)00003-2
更新日期：2003-05-01 00:00:00
abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. In immunocompromised patients, KSHV infection is capable of causing severe and fatal diseases. Current antiviral treatments for KSHV infections consist mostly of n...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104825
更新日期：2020-08-01 00:00:00
abstract：:A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of addition experiments indicate that TGG-II-23A functions at a stage of the HIV-1 life cycle at or near reverse transcription. Cell free assays confirmed that TGG-...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(93)90091-v
更新日期：1993-10-01 00:00:00
abstract：:Desferrioxamine (DFO) is commonly used in therapy as a chelator of ferric ion in disorders of iron overload. We found that DFO inhibits human cytomegalovirus (HCMV) replication in infected cultures of human foreskin fibroblasts (HFF) at concentrations that have been achieved in humans with no significant adverse effec...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(94)90095-7
更新日期：1994-09-01 00:00:00
abstract：:Therapeutic strategies controlling human cytomegalovirus (hCMV) infection are limited due to adverse side effects and emergence of antiviral resistance variants. A compound being evaluated for treating hCMV disease is maribavir (MBV) which disrupts replication by inhibiting the viral kinase pUL97. Previous studies hav...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.09.011
更新日期：2013-11-01 00:00:00
abstract：:Murine cytomegalovirus (MCMV) neither induces a viral thymidine kinase (TK) nor enhances the activity of a cellular TK. Nevertheless, MCMV is highly susceptible to 9-(2-hydroxyethoxymethyl)guanine (acyclovir, ACV). The cellular TK is neither responsible for phosphorylation of ACV nor its anti-MCMV activity. This is cl...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(92)90086-k
更新日期：1992-01-01 00:00:00
abstract：:Favipiravir (T-705) is a broad spectrum antiviral which has been approved in Japan for the treatment of severe influenza virus infections. We reported earlier that favipiravir inhibits the in vitro replication of CHIKV and protects against disease progression in CHIKV-infected immunodeficient mice. We here explored wh...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2017.09.016
更新日期：2018-01-01 00:00:00
abstract：:Several arenaviruses cause hemorrhagic fever (HF) in humans, and evidence indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance. Moreover, arenaviruses pose a biodefense threat. No licensed anti-arenavirus vaccine...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2008.08.002
更新日期：2008-12-01 00:00:00
abstract：:Natural killer (NK) cells are a crucial component of the host innate immune system. We investigated the noncytolytic anti-human immunodeficiency virus (HIV) activity of NK cells in chronically HIV-infected immune cells. Supernatants collected from NK cell cultures (both primary NK cells and NK cell lines, YTS and NK 9...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.08.006
更新日期：2007-02-01 00:00:00
abstract：:Knowledge of drug protein-binding and blood cell partitioning may be important for evaluating the pharmacokinetic parameters of zidovudine, particularly because of its intracellular site of action and potential to induce side effects. Equilibrium dialysis studies of zidovudine were performed over 2 h to identify the e...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(93)90032-e
更新日期：1993-07-01 00:00:00
abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.06.003
更新日期：2013-09-01 00:00:00
abstract：:The effect of interferon on the replication of herpes simplex virus types 1 and 2 was studied in two murine macrophage-like cell lines which differ in their ability to synthesize interferon. Higher titers of herpes simplex virus type 1 occurred in PU5-1.8 cell cultures where interferon was not produced than in J774A.1...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(86)90010-0
更新日期：1986-05-01 00:00:00
abstract：:Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.09.001
更新日期：2008-02-01 00:00:00
abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(01)00150-4
更新日期：2001-09-01 00:00:00
abstract：:Mycophenolate mofetil (MMF), a therapeutically used inhibitor of inosine monophosphate dehydrogenase is hydrolyzed to its active metabolite mycophenolic acid (MPA) in vivo. MPA exhibits anti-HIV activity in vitro. We tested MPA alone and in combination with abacavir (ABC), didanosine (DDI), lamivudine (3TC) and tenofo...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00006-2
更新日期：2002-07-01 00:00:00
abstract：:The aim of the study was to establish a murine model for sensitive screening of potential compounds with in vitro anti-influenza A virus activity. The evaluation in this in vivo model is based on semi-quantitative detection of viral RNA using one-step reverse transcriptase polymerase chain reaction (RT-PCR). After int...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00184-5
更新日期：2003-03-01 00:00:00
abstract：:In an ongoing effort to identify an orally bioavailable compound for the treatment of rhino- and enteroviral infections, a series of vinylacetylene benzimidazoles was recently examined. Previous studies demonstrated the potential for these compounds to possess both good in vitro antiviral activity as well as acceptabl...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(99)00013-3
更新日期：1999-05-01 00:00:00
abstract：:The cupric and ferric complexes of isonicotinic acid hydrazide (INH) inhibit the DNA synthesis catalysed by avian myeloblastosis virus (AMV) reverse transcriptase. The inhibition was to the extent of 95% by 50 microM of cupric-INH complex and 55% by 100 microM of ferric-INH complex. These complexes have been found to ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(82)90052-3
更新日期：1982-10-01 00:00:00
abstract：:Adult woodchucks (Marmota monax) chronically infected with woodchuck hepatitis virus (WHV) were treated orally with lamivudine (15 mg/kg per day) for 57 weeks. After 20 weeks of treatment a 2-3 log reduction in serum WHV DNA was detected. Serum titers of WHV then increased gradually, in the presence of lamivudine trea...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.03.005
更新日期：2004-08-01 00:00:00
abstract：:Site-directed in vitro mutagenesis was used to create analogs of human interferons (IFNs)-alpha 1 and -alpha 4. Analogs were expressed in vitro using SP6 RNA polymerase and a rabbit reticulocyte lysate cell-free protein synthesis system. Amino acid substitutions for the highly conserved residues at positions 33, 121, ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(89)90066-1
更新日期：1989-08-01 00:00:00
abstract：:A newly synthesized imide derivative of 3-nitro-1,8-naphthalic acid, 5-amino-2-(2-dimethylaminoethyl)benzo-[de]-isoquinolin-1,3-dione (designated M-FA-142), was tested on chick embryo cells against herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), and on Vero cells against African swine fever virus (ASFV). ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(84)90018-4
更新日期：1984-08-01 00:00:00
