T cell responses in hepatitis C virus infection: historical overview and goals for future research.

abstract：:Three SAH hydrolase inhibitors, (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) [(RS)-AHPA]; (RS)-9-(2,3-dihydroxypropyl)adenine [(RS)-DHPA] and the carbocyclic analog of 3-deazaadenosine (C-c3Ado) were evaluated for their inhibitory activity against tobacco mosaic virus (TMV) and potato virus X (PVX). Usi...

journal_title：Antiviral research

authors： De Fazio G,Alba AP,Vicente M,De Clercq E

更新日期：1990-05-01 00:00:00

abstract：:Immune evasion by the lethal henipaviruses, Hendra (HeV) and Nipah virus, is mediated by its interferon (IFN) antagonist P gene products, phosphoprotein (P), and the related V and W proteins, which can target the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins to inhibit IFN/STAT signalin...

journal_title：Antiviral research

authors： Lieu KG,Marsh GA,Wang LF,Netter HJ

更新日期：2015-12-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00

abstract：:We studied the effects of two antiviral agents, human interferon-alpha (IFN-alpha) and ribavirin, on subacute sclerosing panencephalitis (SSPE) virus infections in hamsters. By intracranial administration, IFN-alpha alone improved the survival of infected hamsters by 20% at a dose of 6 x 10(4) IU/kg every other day fo...

journal_title：Antiviral research

authors： Takahashi T,Hosoya M,Kimura K,Ohno K,Mori S,Takahashi K,Shigeta S

更新日期：1998-01-01 00:00:00

abstract：:RNA interference, mediated by short interfering RNAs (siRNAs), has been shown to have activity against a wide range of viruses and is a promising new antiviral therapy. Using multiple siRNAs that target conserved areas of the genome allows for increased chances of antiviral activity against different viral strains and...

journal_title：Antiviral research

authors： O'Brien L

更新日期：2007-07-01 00:00:00

abstract：:Infection of captive macaques with simian immunodeficiency virus (SIV) and domestic cats with feline immunodeficiency virus (FIV), both discovered in the last five years, represent excellent animal models for infection of humans with the human immunodeficiency virus (HIV). Protection against challenge infection and pr...

journal_title：Antiviral research

authors： Gardner MB

更新日期：1991-05-01 00:00:00

abstract：:The antiviral activity of antisense oligonucleotides corresponding to different regions of foot-and-mouth disease virus (FMDV) genome has been assessed in BHK-21 cells. The locations of the oligonucleotides used were: (i) two regions within the internal ribosome entry site (IRES), involved in the regulation of the tra...

journal_title：Antiviral research

authors： Gutiérrez A,Rodríguez A,Pintado B,Sobrino F

更新日期：1993-09-01 00:00:00

abstract：:The ability of hypericin to protect mice from splenomegaly resulting from infection with Friend leukemia virus (FLV) was re-examined in light of recent evidence showing that light is absolutely required for this drug's antiviral activity. FLV-induced splenomegaly was not prevented or ameliorated in mice injected with ...

journal_title：Antiviral research

authors： Stevenson NR,Lenard J

更新日期：1993-06-01 00:00:00

abstract：:Current therapies for chronic hepatitis B virus infection (CHB) - nucleos(t)ide analogue reverse transcriptase inhibitors and interferons - result in low rates of functional cure defined as sustained off-therapy seroclearance of hepatitis B surface antigen (HBsAg). One likely reason is the inability of these therapies...

journal_title：Antiviral research

authors： Gish RG,Yuen MF,Chan HL,Given BD,Lai CL,Locarnini SA,Lau JY,Wooddell CI,Schluep T,Lewis DL

更新日期：2015-09-01 00:00:00

abstract：:Various anthraquinones substituted with hydroxyl, amino, halogen, carboxylic acid, substituted aromatic group, and sulfonate were tested to determine their activity against human immunodeficiency virus type 1 (HIV-1) in primary human lymphocytes. Among the compounds tested, polyphenolic and/or polysulfonate substitute...

journal_title：Antiviral research

authors： Schinazi RF,Chu CK,Babu JR,Oswald BJ,Saalmann V,Cannon DL,Eriksson BF,Nasr M

更新日期：1990-05-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) remain prevalent even with widespread use of combination antiretroviral therapy (ART), suggesting a potential role for co-morbidities in neurologic decline. Indeed, it is well established that ART drugs, particularly HIV protease inhibitors, can induce hyperlipidemia, lip...

journal_title：Antiviral research

authors： Gupta S,Knight AG,Losso BY,Ingram DK,Keller JN,Bruce-Keller AJ

更新日期：2012-07-01 00:00:00

abstract：:Lamivudine is no longer recommended as first-line therapy for chronic hepatitis B. The same advice has been made for adefovir and telbivudine, due to their relatively weak anti-viral activity and low resistance barrier, respectively. Instead, either tenofovir or entecavir is the currently preferred anti-HBV agent, giv...

journal_title：Antiviral research

authors： Soriano V,McMahon B

更新日期：2013-11-01 00:00:00

abstract：:This study describes the extent of cross-resistance and interactions for selected inhibitors of human cytomegalovirus (HCMV) DNA synthesis and DNA processing. HCMV isolates resistant to the benzimidazole D-ribonucleoside viral DNA processing inhibitors TCRB and BDCRB were sensitive to BAY 38-4766, a non-nucleoside inh...

journal_title：Antiviral research

authors： Evers DL,Komazin G,Shin D,Hwang DD,Townsend LB,Drach JC

更新日期：2002-10-01 00:00:00

abstract：:PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phos...

journal_title：Antiviral research

authors： Xiong X,Flores C,Fuller MD,Mendel DB,Mulato AS,Moon K,Chen MS,Cherrington JM

更新日期：1997-11-01 00:00:00

abstract：:On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons who required hospitalization and one who died. ADHSS and CDC condu...

journal_title：Antiviral research

authors： Kumaki Y,Woolcott JD,Roth JP,Mclean TZ,Smee DF,Barnard DL,Valiaeva N,Beadle JR,Hostetler KY

更新日期：2018-10-01 00:00:00

abstract：:We investigated the development of anti-pre-S(2) antibodies by enzyme immunoassay and by Western blot analysis in a vaccination study in haemodialysis patients; both the Pasteur plasma vaccine retaining the pre-S(2) epitopes and the Merck, Sharp and Dohme (MSD) plasma vaccine containing only HBsAg were used. By enzyme...

journal_title：Antiviral research

authors： Heijtink RA,de Wilde GA,Kruining J,Smit-Leijs MB,Schalm SW

更新日期：1989-09-01 00:00:00

abstract：:The successful development of antiviral drugs is highly dependent on a close interaction and collaboration between the chemist and the biologist (biomedic). This is illustrated by a number of representative examples: S-adenosylhomocysteine (SAH) hydrolase inhibitors which display broad-spectrum antiviral activity, bro...

journal_title：Antiviral research

authors： De Clercq E

更新日期：2005-08-01 00:00:00

abstract：:The viral genotype and serum viral level influence the response to interferon (IFN) treatment in patients with chronic hepatitis C virus (HCV) viremia. The aim of this study was to investigate a possible relationship between early virological response and helper T (Th) cell cytokine expansion by 4 weeks of ribavirin (...

journal_title：Antiviral research

authors： Furusyo N,Kubo N,Toyoda K,Takeoka H,Nabeshima S,Murata M,Nakamuta M,Hayashi J

更新日期：2005-07-01 00:00:00

abstract：:While combination antiretroviral therapy (cART) has successfully converted HIV to a chronic but manageable infection in many parts of the world, HIV continues to persist within latent cellular reservoirs, which can become reactivated at any time to produce infectious virus. New therapies are therefore needed not only ...

journal_title：Antiviral research

authors： Andersen RJ,Ntie-Kang F,Tietjen I

更新日期：2018-10-01 00:00:00

abstract：:The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle ...

journal_title：Antiviral research

authors： Tobin GJ,Ennis WH,Clanton DJ,Gonda MA

更新日期：1996-12-01 00:00:00

abstract：:In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB...

journal_title：Antiviral research

authors： Giannecchini S,Wise HM,Digard P,Clausi V,Del Poggetto E,Vesco L,Puzelli S,Donatelli I,Azzi A

更新日期：2011-10-01 00:00:00

abstract：:We have characterized the differential actions of acyclovir and penciclovir against varicella-zoster virus (VZV) in cell culture by comparing the frequency of appearance of resistant viruses followed by their characterization. Cells were infected with cell-free virus and the cultures were successively treated with inc...

journal_title：Antiviral research

authors： Ida M,Kageyama S,Sato H,Kamiyama T,Yamamura J,Kurokawa M,Morohashi M,Shiraki K

更新日期：1999-01-01 00:00:00

abstract：:Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this work we first evaluated the antiviral activity of natural and synthetic β-carbolines against DENV-2 multiplication in cell cultures. We determined that the natural β-carboline harmol and a synthetic harmine derivative, 9N-methyl...

journal_title：Antiviral research

authors： Quintana VM,Piccini LE,Panozzo Zénere JD,Damonte EB,Ponce MA,Castilla V

更新日期：2016-10-01 00:00:00

abstract：:The bicyclams represent a new class of highly potent and selective HIV inhibitors. Time-of-addition experiments have previously shown that these compounds interfere with an early event in the viral replicative cycle. Additional experiments have now been carried out in order to investigate in more detail the mechanism ...

journal_title：Antiviral research

authors： De Vreese K,Reymen D,Griffin P,Steinkasserer A,Werner G,Bridger GJ,Esté J,James W,Henson GW,Desmyter J,Anné J,De Clercq I

更新日期：1996-03-01 00:00:00

abstract：:The aminoadamantanes, amantadine and rimantadine, have been used to prevent and treat influenza A virus infections for many years. Several reports have shown an increased level of resistance to these drugs, particularly among influenza A(H3N2) subtype viruses, during recent years. We observed an increase in amantadine...

journal_title：Antiviral research

authors： Yavarian J,Azad TM,Zheng X,Gregory V,Lin YP,Hay A

更新日期：2010-11-01 00:00:00

abstract：:The effect of interferon on the replication of herpes simplex virus types 1 and 2 was studied in two murine macrophage-like cell lines which differ in their ability to synthesize interferon. Higher titers of herpes simplex virus type 1 occurred in PU5-1.8 cell cultures where interferon was not produced than in J774A.1...

journal_title：Antiviral research

authors： Salo RJ,Ortega AP

更新日期：1986-05-01 00:00:00

abstract：:Twenty-four patients with chronic non-A non-B hepatitis were randomly assigned to receive either human fibroblast interferon (HuIFN-beta) at doses of 1 or 3 million international units (MIU) per day for 4 or 12 weeks (12 patients) or to receive no therapy (12 patients), and were then compared with 5 patients with chro...

journal_title：Antiviral research

authors： Kiyosawa K,Sodeyama T,Nakano Y,Yoda H,Tanaka E,Hayata T,Tsuchiya K,Yousuf M,Furuta S

更新日期：1989-10-01 00:00:00

abstract：:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for ca...

journal_title：Antiviral research

authors： Tuppurainen ES,Pearson CR,Bachanek-Bankowska K,Knowles NJ,Amareen S,Frost L,Henstock MR,Lamien CE,Diallo A,Mertens PP

更新日期：2014-09-01 00:00:00

abstract：:Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential. In this study we report that mesuol and isomesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication...

journal_title：Antiviral research

authors： Márquez N,Sancho R,Bedoya LM,Alcamí J,López-Pérez JL,Feliciano AS,Fiebich BL,Muñoz E

更新日期：2005-06-01 00:00:00

abstract：:Vaccination against smallpox may result in a variety of complications, ranging in severity from benign to lethal. Universal vaccination was halted in the US in 1972, so almost half the present population has never been vaccinated. Because side effects occur most often in first-time vaccinees, current plans for rapid l...

journal_title：Antiviral research

authors： Bray M

更新日期：2003-04-01 00:00:00