Natural product-derived compounds in HIV suppression, remission, and eradication strategies.

Abstract:

:While combination antiretroviral therapy (cART) has successfully converted HIV to a chronic but manageable infection in many parts of the world, HIV continues to persist within latent cellular reservoirs, which can become reactivated at any time to produce infectious virus. New therapies are therefore needed not only for HIV suppression but also for containing or eliminating HIV reservoirs. Compounds derived from plant, marine, and other natural products have been found to combat HIV infection and/or target HIV reservoirs, and these discoveries have substantially guided current HIV therapy-based studies. Here we summarize the role of natural product-derived compounds in current HIV suppression, remission, and cure strategies.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Andersen RJ,Ntie-Kang F,Tietjen I

doi

10.1016/j.antiviral.2018.07.016

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

63-77

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(18)30359-0

journal_volume

158

pub_type

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