Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran.

abstract：:The ability of hypericin to protect mice from splenomegaly resulting from infection with Friend leukemia virus (FLV) was re-examined in light of recent evidence showing that light is absolutely required for this drug's antiviral activity. FLV-induced splenomegaly was not prevented or ameliorated in mice injected with ...

journal_title：Antiviral research

authors： Stevenson NR,Lenard J

更新日期：1993-06-01 00:00:00

abstract：:In the absence of antiviral treatment, chronic hepatitis C virus (HCV) infection is a liver disease characterized by the development of necroinflammatory changes and progressive liver fibrosis, leading to cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). The approval of ribavirin in combination th...

journal_title：Antiviral research

authors： Medina J,García-Buey L,Moreno-Monteagudo JA,Trapero-Marugán M,Moreno-Otero R

更新日期：2003-10-01 00:00:00

abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

journal_title：Antiviral research

authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

更新日期：1994-05-01 00:00:00

abstract：:Phosphorothioate-modified oligomers have been shown to be more stable than natural oligomers to serum and cellular nucleases. For this reason we used these analogs to explore the utility of antisense molecules as potential antiviral agents. The oligomers we studied are complementary to the initiation region of the Vmw...

journal_title：Antiviral research

authors： Kmetz ME,Ceruzzi M,Schwartz J

更新日期：1991-09-01 00:00:00

abstract：:Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice...

journal_title：Antiviral research

authors： Guillemard E,Geniteau-Legendre M,Kergot R,Lemaire G,Petit JF,Labarre C,Quero AM

更新日期：1995-10-01 00:00:00

abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

journal_title：Antiviral research

authors： Kariya M,Mori S,Eizuru Y

更新日期：2000-02-01 00:00:00

abstract：:Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with ...

journal_title：Antiviral research

authors： Ida H,Kurata A,Eguchi K,Yamashita I,Nakashima M,Sakai M,Kawabe Y,Nakamura T,Nagataki S

更新日期：1994-02-01 00:00:00

abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...

journal_title：Antiviral research

authors： de Mareuil J,Mabrouk K,Doria E,Moulard M,de Chasteigner S,Oughideni R,van Rietschoten J,Rochat H,De Waard M,Sabatier JM

更新日期：2002-06-01 00:00:00

abstract：:HIV-infected patients are at increased risk of decreased bone mineral density. Several studies have implicated antiretroviral therapy as a contributor to the decreased bone mineral density seen in treated HIV-1 patients. Whilst the exact molecular mechanisms underlying decreased bone density remain to be elucidated, i...

journal_title：Antiviral research

authors： Malizia AP,Vioreanu MH,Doran PP,Powderly WG

更新日期：2007-04-01 00:00:00

abstract：:Global eradication of hepatitis C virus (HCV) infection will require an efficacious vaccine capable of eliciting protective immunity against genetically diverse HCV strains. Natural spontaneous resolution of HCV infection is associated with production of broadly-neutralizing antibodies targeting the HCV glycoproteins ...

journal_title：Antiviral research

authors： Tarr AW,Backx M,Hamed MR,Urbanowicz RA,McClure CP,Brown RJP,Ball JK

更新日期：2018-12-01 00:00:00

abstract：:The biological response modifier 7-thia-8-oxoguanosine was evaluated in mice against the hepatotropic Adames strain of Punta Toro virus. When administered intraperitoneally in divided doses, significant protection from death was conferred at doses of 50 and 100 mg/kg/day given 24 and 17 h pre-virus inoculation, 25-100...

journal_title：Antiviral research

authors： Smee DF,Huffman JH,Gessaman AC,Huggins JW,Sidwell RW

更新日期：1991-03-01 00:00:00

abstract：:Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection of which there is no licensed therapeutic drug available. Previous studies have shown that minocycline, an antibiotic, can inhibit DENV infection in vitro. However, the mechanism is not fully understood. It is known that macrophage migr...

journal_title：Antiviral research

authors： Lai YC,Chuang YC,Chang CP,Lin YS,Perng GC,Wu HC,Hsieh SL,Yeh TM

更新日期：2018-07-01 00:00:00

abstract：:Since it was discovered as the first human tumor virus in 1964, Epstein-Barr Virus (EBV) is now implicated in several types of malignancies. Accordingly, certain aspects of EBV pathobiology have shown promise in anti-cancer research in developing virus-targeting methods for EBV-associated cancers. The unique role of E...

journal_title：Antiviral research

authors： Shen CL,Huang WH,Hsu HJ,Yang JH,Peng CW

更新日期：2019-04-01 00:00:00

abstract：:Nalidixic acid and oxolinic acid, two antibacterial agents known to inhibit bacterial DNA gyrase, are shown to suppress the replication, as well as the cytopathic effect, of BK virus in Vero cell cultures. The inhibition of virus replication was detectable at day 4 post infection in cultures which had been continuousl...

journal_title：Antiviral research

authors： Portolani M,Pietrosemoli P,Cermelli C,Mannini-Palenzona A,Grossi MP,Paolini L,Barbanti-Brodano G

更新日期：1988-04-01 00:00:00

abstract：:The first 230 residues of the 298-amino acid glycoprotein G of respiratory syncytial virus (RSV) are sufficient to confer complete resistance to challenge with live RSV, whereas the first 180 residues completely failed (Olmsted et al. (1989) J. Virol. 63, 411-420). The characterization of a protective epitope correspo...

journal_title：Antiviral research

authors： Simard C,Nadon F,Séguin C,Trudel M

更新日期：1995-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play important roles in modulating diverse physiological processes. Recent studies show that FoxOs are involved in antiviral responses. In present investigation, we...

journal_title：Antiviral research

authors： Li L,Li Y,Xiong Z,Shu W,Yang Y,Guo Z,Gao B

更新日期：2019-10-01 00:00:00

abstract：:Vaccination of chickens with herpesvirus of turkey (HVT) confers only partial protection against challenge with a very virulent Marek's disease virus (MDV). Here, we evaluated the ability of recombinant chicken interferon-gamma (rChIFN-γ) to enhance protective efficacy of HVT against the very virulent MDV strain, RB1B...

journal_title：Antiviral research

authors： Haq K,Elawadli I,Parvizi P,Mallick AI,Behboudi S,Sharif S

更新日期：2011-06-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. In immunocompromised patients, KSHV infection is capable of causing severe and fatal diseases. Current antiviral treatments for KSHV infections consist mostly of n...

journal_title：Antiviral research

authors： Chen J,Zhang H,Chen X

更新日期：2020-08-01 00:00:00

abstract：:Drug resistance resulting from reverse transcriptase (RT) mutations is one of the main obstacles to successful hepatitis B virus (HBV) therapy. Indeed, HBV treatment guidelines recommend HBV genotypic resistance testing for patients receiving nucleos(t)ide RT inhibitors (N(t)RTIs) who develop virological failure. N(t)...

journal_title：Antiviral research

authors： Rhee SY,Margeridon-Thermet S,Nguyen MH,Liu TF,Kagan RM,Beggel B,Verheyen J,Kaiser R,Shafer RW

更新日期：2010-12-01 00:00:00

abstract：:Flaviviruses constitute a public health concern because of their global burden and the lack of specific antiviral treatment. Here we investigated the antiviral activity of the alkaloid anisomycin against dengue (DENV) and Zika (ZIKV) viruses. At non-cytotoxic concentrations, anisomycin strongly inhibited the replicati...

journal_title：Antiviral research

authors： Quintana VM,Selisko B,Brunetti JE,Eydoux C,Guillemot JC,Canard B,Damonte EB,Julander JG,Castilla V

更新日期：2020-04-01 00:00:00

abstract：:Antiviral compounds were evaluated for efficacy against yellow fever virus (YFV) in a hamster model of YFV-induced liver disease. Challenge with a 10(2) 50% cell culture infectious doses of YFV resulted in a 50-80% mortality rate in female hamsters. Virus was detected by quantitative real-time RT-PCR (QRT-PCR) in live...

journal_title：Antiviral research

authors： Julander JG,Morrey JD,Blatt LM,Shafer K,Sidwell RW

更新日期：2007-02-01 00:00:00

abstract：:Lamivudine is no longer recommended as first-line therapy for chronic hepatitis B. The same advice has been made for adefovir and telbivudine, due to their relatively weak anti-viral activity and low resistance barrier, respectively. Instead, either tenofovir or entecavir is the currently preferred anti-HBV agent, giv...

journal_title：Antiviral research

authors： Soriano V,McMahon B

更新日期：2013-11-01 00:00:00

abstract：:An estimated 15-20 million individuals are co-infected by hepatitis B and hepatitis D virus worldwide and are at high risk of developing end-stage liver disease, including hepatocellular carcinoma. While HBV viremia can now be controlled in the vast majority of individuals by nucleoside analogs, leading to a delay of ...

journal_title：Antiviral research

authors： Alfaiate D,Dény P,Durantel D

更新日期：2015-10-01 00:00:00

abstract：:Viramidine, the 3-carboxamidine derivative of ribavirin, was effective against a spectrum of influenza A (H1N1, H3N2 and H5N1) and B viruses in vitro, with the 50% effective concentration (EC50) ranging from 2 to 32 microg/ml. The mean 50% cytotoxic concentration (CC50) in the MDCK cells used in these experiments was ...

journal_title：Antiviral research

authors： Sidwell RW,Bailey KW,Wong MH,Barnard DL,Smee DF

更新日期：2005-10-01 00:00:00

abstract：:Nucleoside analogues have been the most successful antiviral compounds. Likewise, they are the most intriguing antiviral compounds, because of their structural relationship to natural nucleosides. This is also the reason why the design process of a potential selective antiviral nucleoside is so difficult. Too many nat...

journal_title：Antiviral research

authors： Herdewijn P

更新日期：2006-09-01 00:00:00

abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients and might play a role in the pathogenesis of inflammatory bowel disease (IBD). 6-Thioguanine (6-TG) has been widely used as an immunosuppressive drug for organ recipients and treatment of IBD in the clinic. This ...

journal_title：Antiviral research

authors： Yin Y,Chen S,Hakim MS,Wang W,Xu L,Dang W,Qu C,Verhaar AP,Su J,Fuhler GM,Peppelenbosch MP,Pan Q

更新日期：2018-08-01 00:00:00

abstract：:For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...

journal_title：Antiviral research

authors： Peterson SE,Wang S,Ranheim T,Owen KE

更新日期：2006-02-01 00:00:00

abstract：:Serious outbreaks of severe acute respiratory syndrome (SARS), caused by the newly discovered coronavirus SARS-CoV, occurred between late 2002 and early 2003 and there is an urgent need for effective antiviral agents. RNA interference in animals and post-transcriptional gene silencing plants is mediated by small doubl...

journal_title：Antiviral research

authors： Wu CJ,Huang HW,Liu CY,Hong CF,Chan YL

更新日期：2005-01-01 00:00:00

abstract：:The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in m...

journal_title：Antiviral research

authors： Idowu AD,Fraser-Smith EB,Poffenberger KL,Herman RC

更新日期：1992-02-01 00:00:00

abstract：:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated...

journal_title：Antiviral research

authors： Rockx B,Winegar R,Freiberg AN

更新日期：2012-08-01 00:00:00