Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses.

abstract：:Conventional treatment of severe viral disease is limited by the narrow choice as well as the often-significant side effects or lack of clear efficacy of antiviral chemotherapy. At the same time, however, it is known that a reduction in viral load leads to significant clinical improvement in a number of important vira...

journal_title：Antiviral research

authors： Oberender F,Oberender H,Altrichter J,Reisinger EC,Mitzner SR

更新日期：2010-08-01 00:00:00

abstract：:3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The...

journal_title：Antiviral research

authors： Vrang L,Bazin H,Remaud G,Chattopadhyaya J,Oberg B

更新日期：1987-03-01 00:00:00

abstract：:Several nucleoside reverse transcriptase inhibitors are associated with mitochondrial toxicity resulting from inhibition of DNA polymerase-gamma. This study compared the effects on mitochondrial DNA of apricitabine (previously referred to as AVX754 or SPD754), a novel cytidine analogue under development for the treatm...

journal_title：Antiviral research

authors： de Baar MP,de Rooij ER,Smolders KG,van Schijndel HB,Timmermans EC,Bethell R

更新日期：2007-10-01 00:00:00

abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients and might play a role in the pathogenesis of inflammatory bowel disease (IBD). 6-Thioguanine (6-TG) has been widely used as an immunosuppressive drug for organ recipients and treatment of IBD in the clinic. This ...

journal_title：Antiviral research

authors： Yin Y,Chen S,Hakim MS,Wang W,Xu L,Dang W,Qu C,Verhaar AP,Su J,Fuhler GM,Peppelenbosch MP,Pan Q

更新日期：2018-08-01 00:00:00

abstract：:Many aspects of the biology and epidemiology of influenza B viruses are far less studied than for influenza A viruses, and one of these aspects is efficacy and resistance to the clinically available antiviral drugs, the neuraminidase (NA) inhibitors (NAIs). Acute respiratory infections are one of the leading causes of...

journal_title：Antiviral research

authors： Burnham AJ,Baranovich T,Govorkova EA

更新日期：2013-11-01 00:00:00

abstract：:During studies of the antiviral activity of chalcone Ro-09-0410 on human rhinovirus type 9 (RV9) chalcone-resistant strains of RV9 were isolated and appeared with a frequency of about 10(-5) in chalcone sensitive stock. Chalcone-dependent viruses were found after further passage. Some characteristics of the resistant ...

journal_title：Antiviral research

authors： Ahmad AL,Dowsett AB,Tyrrell DA

更新日期：1987-08-01 00:00:00

abstract：:Despite an urgent medical need, a broadly effective anti-viral therapy for the treatment of infections with hepatitis C viruses (HCVs) has yet to be developed. One of the approaches to anti-HCV drug discovery is the design and development of specific small molecule drugs to inhibit the proteolytic processing of the HC...

journal_title：Antiviral research

authors： Kwong AD,Kim JL,Rao G,Lipovsek D,Raybuck SA

更新日期：1999-02-01 00:00:00

abstract：:In the event of a bioterror attack with variola virus (smallpox), exposure may only be identified following onset of fever. To determine if antiviral therapy with brincidofovir (BCV; CMX001) initiated at, or following, onset of fever could prevent severe illness and death, a lethal rabbitpox model was used. BCV is in ...

journal_title：Antiviral research

authors： Grossi IM,Foster SA,Gainey MR,Krile RT,Dunn JA,Brundage T,Khouri JM

更新日期：2017-07-01 00:00:00

abstract：:Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral structural component r...

journal_title：Antiviral research

authors： Noble CG,Li SH,Dong H,Chew SH,Shi PY

更新日期：2014-11-01 00:00:00

abstract：:Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identificatio...

journal_title：Antiviral research

authors： Prichard MN,Kern ER

更新日期：2012-05-01 00:00:00

abstract：:Several novel γ-carboline derivatives were identified as selective inhibitors of bovine viral diarrhea virus (BVDV) replication in cell cultures. Among them, 3,4,5-trimethyl-γ-carboline (SK3M4M5M) was the most active against BVDV (Nose strain) in MDBK cells, with a 50% effective concentration of 0.017±0.005μM and a se...

journal_title：Antiviral research

authors： Salim MT,Goto Y,Hamasaki T,Okamoto M,Aoyama H,Hashimoto Y,Musiu S,Paeshuyse J,Neyts J,Froeyen M,Herdewijn P,Baba M

更新日期：2010-12-01 00:00:00

abstract：:We have previously reported a new class of dendrimers with tryptophan (Trp) residues on the surface that show dual antiviral activities against HIV and enterovirus EV71. The prototype compound of this family is a derivative of pentaerythritol with 12 peripheral Trp groups and trivalent spacer arms. Here a novel series...

journal_title：Antiviral research

authors： Martínez-Gualda B,Sun L,Martí-Marí O,Mirabelli C,Delang L,Neyts J,Schols D,Camarasa MJ,San-Félix A

更新日期：2019-08-01 00:00:00

abstract：:Sheeppox and goatpox, two endemic capripox infections in India, pose a significant economic threat to small ruminant productivity in the subcontinent. Vaccination of all susceptible sheep and goats is the feasible and sustainable means of control. Availability of effective live attenuated vaccines that are inherently ...

journal_title：Antiviral research

authors： Bhanuprakash V,Hosamani M,Singh RK

更新日期：2011-09-01 00:00:00

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the sa...

journal_title：Antiviral research

authors： Luo H,Winkelmann ER,Fernandez-Salas I,Li L,Mayer SV,Danis-Lozano R,Sanchez-Casas RM,Vasilakis N,Tesh R,Barrett AD,Weaver SC,Wang T

更新日期：2018-03-01 00:00:00

abstract：:As part of our studies on the molecular basis for the antiherpes activity of 5'-AdThd (5'-amino-5'-deoxythymidine), a study of the HSV-1 DNA synthesized in infected Vero cells exposed to 5'-AdThd was undertaken. Unlike many other antiviral nucleoside analogs, 5'-AdThd did not inhibit HSV-1 DNA synthesis. Analysis of t...

journal_title：Antiviral research

authors： Otto MJ,Prusoff WH

更新日期：1984-10-01 00:00:00

abstract：:Although in vitro studies have been performed to dissect the mechanism of action of IFNα, detailed in vivo studies on the long-term effects of IFNα on monocytes have not been performed. Here we examined peripheral blood from 14 chronic HCV patients at baseline and 12 weeks after start of IFNα-based therapy. Monocytes ...

journal_title：Antiviral research

authors： Hou J,Groothuismink ZM,Koning L,Roomer R,van IJcken WF,Kreefft K,Liu BS,Janssen HL,de Knegt RJ,Boonstra A

更新日期：2014-09-01 00:00:00

abstract：:Global eradication of hepatitis C virus (HCV) infection will require an efficacious vaccine capable of eliciting protective immunity against genetically diverse HCV strains. Natural spontaneous resolution of HCV infection is associated with production of broadly-neutralizing antibodies targeting the HCV glycoproteins ...

journal_title：Antiviral research

authors： Tarr AW,Backx M,Hamed MR,Urbanowicz RA,McClure CP,Brown RJP,Ball JK

更新日期：2018-12-01 00:00:00

abstract：:The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (GCV) showed concentration-dependent inhibitory properties from 0.05 to 3....

journal_title：Antiviral research

authors： Akuzawa K,Yamada R,Li Z,Li Y,Sadanari H,Matsubara K,Watanabe K,Koketsu M,Tuchida Y,Murayama T

更新日期：2011-09-01 00:00:00

abstract：:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly ass...

journal_title：Antiviral research

authors： Jabs DA

更新日期：1996-01-01 00:00:00

abstract：:Adult woodchucks (Marmota monax) chronically infected with woodchuck hepatitis virus (WHV) were treated orally with lamivudine (15 mg/kg per day) for 57 weeks. After 20 weeks of treatment a 2-3 log reduction in serum WHV DNA was detected. Serum titers of WHV then increased gradually, in the presence of lamivudine trea...

journal_title：Antiviral research

authors： Jacob JR,Korba BE,Cote PJ,Toshkov I,Delaney WE 4th,Gerin JL,Tennant BC

更新日期：2004-08-01 00:00:00

abstract：:Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of ...

journal_title：Antiviral research

authors： Kneidinger D,Ibrišimović M,Lion T,Klein R

更新日期：2012-06-01 00:00:00

abstract：:Previous studies of IFN-stimulated transcription factors in murine cells have identified a variety of trans-acting factors that bind to the IFN-stimulated response element (ISRE) whose role in gene expression remain unclear. The present investigation was undertaken to delineate the signal transduction pathway as well ...

journal_title：Antiviral research

authors： Kalvakolanu DV,Mannino SB,Thornton A,Ozato K,Borden EC

更新日期：1994-10-01 00:00:00

abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...

journal_title：Antiviral research

authors： Ovcharenko AV,Zhirnov OP

更新日期：1994-02-01 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) infection is known to cause skin blisters, keratitis as well as deadly cases of encephalitis in some situations. Only a few therapeutic modalities are available for this globally prevalent infection. Very recently, a small molecule BX795 was identified as an inhibitor of HSV-1 protein sy...

journal_title：Antiviral research

authors： Iqbal A,Suryawanshi R,Yadavalli T,Volety I,Shukla D

更新日期：2020-08-01 00:00:00

abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...

journal_title：Antiviral research

authors： de Mareuil J,Mabrouk K,Doria E,Moulard M,de Chasteigner S,Oughideni R,van Rietschoten J,Rochat H,De Waard M,Sabatier JM

更新日期：2002-06-01 00:00:00

abstract：:Infection with the oncogenic γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) cause several severe malignancies in humans. Inhibition of the lytic replication of EBV and KSHV eliminates the reservoir of persistent infection and transmission, consequently preventing the occurr...

journal_title：Antiviral research

authors： Huang L,Yang M,Yuan Y,Li X,Kuang E

更新日期：2017-02-01 00:00:00

abstract：:Isolation of rhinoviruses from nasal secretions may be delayed or prevented by exogenously applied interferon which is carried over into nasal wash specimens. In studies of interferon-alpha 2 treated volunteers with experimental rhinovirus infection, we determined that incorporation of antiinterferon antibody into col...

journal_title：Antiviral research

authors： Hayden FG,Gwaltney JM Jr

更新日期：1983-03-01 00:00:00

abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...

journal_title：Antiviral research

authors： Ingate S,De Clercq E,Balzarini J,Camarasa MJ

更新日期：1996-11-01 00:00:00

abstract：:In the event of an influenza pandemic, the use of oseltamivir (OTV) will undoubtedly increase and therefore it is more likely that OTV-resistant influenza strains will also arise. OTV-resistance genotyping using sequence-based testing on viruses isolated in cell culture is time consuming and less likely to detect the ...

journal_title：Antiviral research

authors： Steain MC,Dwyer DE,Hurt AC,Kol C,Saksena NK,Cunningham AL,Wang B

更新日期：2009-12-01 00:00:00

abstract：:Resveratrol (RV), a polyphenolic natural product present in many plants and fruits, exhibits anti-inflammatory, cardio-protective and anti-proliferative properties. Moreover, RV affects a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering...

journal_title：Antiviral research

authors： De Leo A,Arena G,Lacanna E,Oliviero G,Colavita F,Mattia E

更新日期：2012-11-01 00:00:00