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Liposomal encapsulation enhances antiviral efficacy of SPC3 against human immunodeficiency virus type-1 infection in human lymphocytes.

Abstract：

:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, either different in size (mean diameter of 100 and 250 nm), SPC3 concentration or cholesterol content. Liposome-associated SPC3 were tested for both inhibition of cell-cell fusion and infection with HIV-1 clones. SPC3 inhibited HIV-1-induced fusion at a micromolar concentration range. When associated with liposomes, SPC3 was found to be about 10-fold more potent than free SPC3 in inhibiting syncytium formation. Continuous treatment with free SPC3 also inhibited virus production in a dose-dependent manner, with inhibition of HIV infection of C8166 T-cells or human peripheral blood lymphocytes (PBLs) at micromolar concentrations. Liposomal entrapment was found to increase the antiviral efficacy of SPC3 by more than 10- and 5-fold in C8166 and PBLs, respectively. These data suggest that the liposome approach may be used to improve SPC3 antiviral efficacy.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

de Mareuil J,Mabrouk K,Doria E,Moulard M,de Chasteigner S,Oughideni R,van Rietschoten J,Rochat H,De Waard M,Sabatier JM

doi

10.1016/s0166-3542(02)00002-5

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

175-88

issue

3

eissn

0166-3542

issn

1872-9096

pii

S0166354202000025

journal_volume

54

pub_type

杂志文章

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