Transcriptional induction of genes by IFN-beta in mouse cells is regulated by a transcription factor similar to human ISGF-3.

abstract：:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM ...

journal_title：Antiviral research

authors： Tang Q,Li S,Du L,Chen S,Gao J,Cai Y,Xu Z,Zhao Z,Lan K,Wu S

更新日期：2020-01-01 00:00:00

abstract：:AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not clear. Thus, the affects of PIs on adipocyte differentiation were examined in vitro using C3H10T1/2 stem cells. In these cells the PIs, nelfinavir, saquinavir, ...

journal_title：Antiviral research

authors： Lenhard JM,Furfine ES,Jain RG,Ittoop O,Orband-Miller LA,Blanchard SG,Paulik MA,Weiel JE

更新日期：2000-08-01 00:00:00

abstract：:Tea is the second most consumed drink in the world. The beneficial effects of tea have been mostly attributed to its catechin content. Black tea is derived from the leaves of Camellia sinensis plant, and it is rich in theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3...

journal_title：Antiviral research

authors： de Oliveira A,Prince D,Lo CY,Lee LH,Chu TC

更新日期：2015-06-01 00:00:00

abstract：:Sheeppox and goatpox, two endemic capripox infections in India, pose a significant economic threat to small ruminant productivity in the subcontinent. Vaccination of all susceptible sheep and goats is the feasible and sustainable means of control. Availability of effective live attenuated vaccines that are inherently ...

journal_title：Antiviral research

authors： Bhanuprakash V,Hosamani M,Singh RK

更新日期：2011-09-01 00:00:00

abstract：:More than 50% of a group of healthy homosexuals in Israel were found to have an activated interferon (IFN) system as evidenced by markedly elevated blood IFN levels, increased in vitro production of IFN by unstimulated peripheral blood mononuclear cells and HuIFN-alpha and HuIFN-gamma production by appropriately stimu...

journal_title：Antiviral research

authors： Levin S,Hahn T,Handzel ZT,Galili-Wiesstub E,Bregman V,Myer R,Tinowitz M,Altman Y,Barzilai N,Brenner Y

更新日期：1985-08-01 00:00:00

abstract：:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for ca...

journal_title：Antiviral research

authors： Tuppurainen ES,Pearson CR,Bachanek-Bankowska K,Knowles NJ,Amareen S,Frost L,Henstock MR,Lamien CE,Diallo A,Mertens PP

更新日期：2014-09-01 00:00:00

abstract：:Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune de...

journal_title：Antiviral research

authors： Morrey JD,Warren RP,Okleberry KM,Burger RA,Chirigos MA,Sidwell RW

更新日期：1991-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) is the most common cause of congenital infection in the developed world and can lead to a life-threatening disease. We therefore developed an animal model to evaluate candidate anti-CMV drugs and to further define the pathogenesis of CMV infections. Newborn guinea pigs were infected by intraperit...

journal_title：Antiviral research

authors： Bravo FJ,Bourne N,Schleiss MR,Bernstein DI

更新日期：2003-09-01 00:00:00

abstract：:Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (HSV). Decoy receptors can target pathogens by binding to the receptor...

journal_title：Antiviral research

authors： Hendricks GL,Velazquez L,Pham S,Qaisar N,Delaney JC,Viswanathan K,Albers L,Comolli JC,Shriver Z,Knipe DM,Kurt-Jones EA,Fygenson DK,Trevejo JM,Wang JP,Finberg RW

更新日期：2015-04-01 00:00:00

abstract：:A recombinant baculovirus (vAc-gC1) was constructed that expresses the glycoprotein C (gC) gene of herpes simplex virus type 1 (HSV-1). When Sf9 cells were infected with this recombinant, a protein that was smaller in size than authentic HSV-1 gC was detected by Western blotting using anti-gC polyclonal antibody. The ...

journal_title：Antiviral research

authors： Ghiasi H,Kaiwar R,Nesburn AB,Wechsler SL

更新日期：1992-06-01 00:00:00

abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...

journal_title：Antiviral research

authors： Ovcharenko AV,Zhirnov OP

更新日期：1994-02-01 00:00:00

abstract：:Infection with Junín virus (JUNV) is currently being effectively managed in the endemic region using a combination of targeted vaccination and plasma therapy. However, the long-term sustainability of plasma therapy is unclear and similar resources are not available for other New World arenaviruses. As a result, there ...

journal_title：Antiviral research

authors： Dunham EC,Leske A,Shifflett K,Watt A,Feldmann H,Hoenen T,Groseth A

更新日期：2018-09-01 00:00:00

abstract：:We have shown previously that prostratin, a non-tumor promoting phorbol ester, inhibits chikungunya virus (CHIKV)-induced cytopathic effects in vitro. Prostratin is a potent activator of protein kinases C (PKC), a family of related serine/threonine kinases that regulate many cellular processes such as proliferation an...

journal_title：Antiviral research

authors： Abdelnabi R,Amrun SN,Ng LF,Leyssen P,Neyts J,Delang L

更新日期：2017-03-01 00:00:00

abstract：:We have analyzed a panel of protein kinase inhibitors (PKIs) and found that some indolocarbazoles (Gö6976, K252a, K252c) proved to be highly effective inhibitors of GCV-sensitive and -resistant human cytomegalovirus (HCMV) strains, but did not show any effect against herpes simplex virus. Antiviral activity was determ...

journal_title：Antiviral research

authors： Zimmermann A,Wilts H,Lenhardt M,Hahn M,Mertens T

更新日期：2000-10-01 00:00:00

abstract：:In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is still unclear what the evolutionary advantage of such heavy chain-only a...

journal_title：Antiviral research

authors： Vanlandschoot P,Stortelers C,Beirnaert E,Ibañez LI,Schepens B,Depla E,Saelens X

更新日期：2011-12-01 00:00:00

abstract：:Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5%. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Avail...

journal_title：Antiviral research

authors： Gan HJ,Harikishore A,Lee J,Jeon S,Rajan S,Chen MW,Neo JL,Kim S,Yoon HS

更新日期：2021-01-01 00:00:00

abstract：:Using several herbal extracts, we investigated whether certain Kampo medicines exert an inhibitory effect on the acidification of intracellular compartments such as endosomes and lysosomes (referred to as ELS), and thereby inhibit the growth of influenza A virus in Madin-Darby canine kidney cells. The vital fluorescen...

journal_title：Antiviral research

authors： Mantani N,Andoh T,Kawamata H,Terasawa K,Ochiai H

更新日期：1999-12-31 00:00:00

abstract：:Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) was examined for its activity against tomato-spotted wilt virus (TSWV) in tomato plants. Solutions containing 50, 100, 200, 400 and 800 mg/l of the drug were sprayed onto the leaves. The results showed that 100 and 200 mg/l were the most efficient concentration...

journal_title：Antiviral research

authors： Caner J,Amélia M,Alexandre V,Vicente M

更新日期：1984-12-01 00:00:00

abstract：:HSV-1 multiplication rates have been shown to vary in different tissues and the rate of multiplication may correlate with susceptibility to antiviral chemotherapy. Herpetic stromal keratitis is a necrotizing condition refractive to antiviral therapy and this lack of antiviral efficacy in stromal disease may be the res...

journal_title：Antiviral research

authors： Upadhyay JM,Hill JM,Jemison M,Helmy MF,Kaufman HE

更新日期：1991-01-01 00:00:00

abstract：:The era of antiviral chemotherapy started more than 50 years with the findings by Domagk and his colleagues that thiosemicarbazones showed activity against vaccinia virus. One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. With the successful implementation of the smallpox vacci...

journal_title：Antiviral research

authors： Neyts J,De Clercq E

更新日期：2003-01-01 00:00:00

abstract：:Influenza virus continues to remain one of the leading human respiratory pathogens causing significant morbidity and mortality around the globe. Due to short-term life cycle and high rate of mutations influenza virus is able to rapidly develop resistance to clinically available antivirals. This makes necessary the sea...

journal_title：Antiviral research

authors： Zarubaev VV,Garshinina AV,Tretiak TS,Fedorova VA,Shtro AA,Sokolova AS,Yarovaya OI,Salakhutdinov NF

更新日期：2015-08-01 00:00:00

abstract：:A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of addition experiments indicate that TGG-II-23A functions at a stage of the HIV-1 life cycle at or near reverse transcription. Cell free assays confirmed that TGG-...

journal_title：Antiviral research

authors： Alam M,Bechtold CM,Patick AK,Skoog MT,Gant TG,Colonno RJ,Meyers AI,Li H,Trimble J,Lin PF

更新日期：1993-10-01 00:00:00

abstract：:The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle ...

journal_title：Antiviral research

authors： Tobin GJ,Ennis WH,Clanton DJ,Gonda MA

更新日期：1996-12-01 00:00:00

abstract：:Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for 7 days with pritelivir or acyclovir. Both drugs were administered ora...

journal_title：Antiviral research

authors： Quenelle DC,Birkmann A,Goldner T,Pfaff T,Zimmermann H,Bonsmann S,Collins DJ,Rice TL,Prichard MN

更新日期：2018-01-01 00:00:00

abstract：:3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The...

journal_title：Antiviral research

authors： Vrang L,Bazin H,Remaud G,Chattopadhyaya J,Oberg B

更新日期：1987-03-01 00:00:00

abstract：:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly ass...

journal_title：Antiviral research

authors： Jabs DA

更新日期：1996-01-01 00:00:00

abstract：:The effects of caps, dinucleotides, oligonucleotides and polynucleotides on influenza virus RNA polymerase activity have been investigated. The results show that both methyl groups in a cap are necessary for optimal stimulation of polymerase activity. Both m7G(5')ppp(5')Am and ApG stimulated the influenza RNA polymera...

journal_title：Antiviral research

authors： Stridh S,Oberg B,Chattopadhyaya J,Josephson S

更新日期：1981-06-01 00:00:00

abstract：:Novel analogues of the anti-HIV-1 agent TSAO-T, [1-[2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]thymine]-3'-spiro-5"-(4"-amino- 1",2"-oxathiole-2",2"-dioxide) and its 3-methyl counterpart TSAO-m3T were obtained by modifications at positions 2' or 5' of the sugar moiety. These compounds were evaluated f...

journal_title：Antiviral research

authors： Ingate S,Pérez-Pérez MJ,De Clercq E,Balzarini J,Camarasa MJ

更新日期：1995-06-01 00:00:00

abstract：:Acute lower respiratory tract infections (ALRI) caused by respiratory syncytial virus (RSV) are associated with a severe disease burden among infants and elderly patients. Treatment options are limited. While numerous drug candidates with different viral targets are under development, the utility of RSV entry inhibito...

journal_title：Antiviral research

authors： Blockus S,Sake SM,Wetzke M,Grethe C,Graalmann T,Pils M,Le Goffic R,Galloux M,Prochnow H,Rox K,Hüttel S,Rupcic Z,Wiegmann B,Dijkman R,Rameix-Welti MA,Eléouët JF,Duprex WP,Thiel V,Hansen G,Brönstrup M,Haid S,Piets

更新日期：2020-05-01 00:00:00

abstract：:Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-...

journal_title：Antiviral research

authors： Ong EZ,Budigi Y,Tan HC,Robinson LN,Rowley KJ,Winnett A,Hobbie S,Shriver Z,Babcock GJ,Ooi EE

更新日期：2017-08-01 00:00:00