Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates.

abstract：:Herpesviruses encode a protease that is essential for virus replication. The protease undergoes cleavage to a processed form during capsid maturation. A recombinant 75 kDa form of the protease from human cytomegalovirus was purified and compared with the recombinant 29 kDa processed form. Modification with an active s...

journal_title：Antiviral research

authors： Wittwer AJ,Funckes-Shippy CL,Hippenmeyer PJ

更新日期：2002-08-01 00:00:00

abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...

journal_title：Antiviral research

authors： Jiang Y,Liu S,Shen S,Guo H,Huang H,Wei W

更新日期：2020-04-01 00:00:00

abstract：:There are no drugs approved specifically to treat disseminated adenovirus (Ad) infections in humans. Cidofovir is active against Ad in cell culture, and it is used frequently in the clinic with disseminated infection in pediatric transplant patients; however, controlled clinical studies have not been conducted to prov...

journal_title：Antiviral research

authors： Tollefson AE,Spencer JF,Ying B,Buller RM,Wold WS,Toth K

更新日期：2014-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) replicates in quiescent T cells, neurons, and skin cells. In cultured fibroblasts (HFFs), VZV induces host cyclin expression and cyclin-dependent kinase (CDK) activity without causing cell cycle progression. CDK1/cyclin B1 phosphorylates the major viral transactivator, and the CDK inhibito...

journal_title：Antiviral research

authors： Rowe J,Greenblatt RJ,Liu D,Moffat JF

更新日期：2010-06-01 00:00:00

abstract：:Drug resistance testing has proven its use to guide treatment decisions in HIV-1 infected patients. Genotyping is the preferred technique for clinical drug resistance testing. Many factors complicate the interpretation of mutations towards therapy response, such that an interpretation system is necessary to help the c...

journal_title：Antiviral research

authors： Vercauteren J,Vandamme AM

更新日期：2006-09-01 00:00:00

abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

journal_title：Antiviral research

authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

更新日期：1994-05-01 00:00:00

abstract：:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM ...

journal_title：Antiviral research

authors： Tang Q,Li S,Du L,Chen S,Gao J,Cai Y,Xu Z,Zhao Z,Lan K,Wu S

更新日期：2020-01-01 00:00:00

abstract：:Viramidine, the 3-carboxamidine derivative of ribavirin, was effective against a spectrum of influenza A (H1N1, H3N2 and H5N1) and B viruses in vitro, with the 50% effective concentration (EC50) ranging from 2 to 32 microg/ml. The mean 50% cytotoxic concentration (CC50) in the MDCK cells used in these experiments was ...

journal_title：Antiviral research

authors： Sidwell RW,Bailey KW,Wong MH,Barnard DL,Smee DF

更新日期：2005-10-01 00:00:00

abstract：:Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately seven days to induce protection. Therefore, antiviral strategies are needed to provide earlier prote...

journal_title：Antiviral research

authors： Molina GN,Cacciabue M,Gismondi MI,Taboga O,Molinari P

更新日期：2020-08-01 00:00:00

abstract：:DNA immunizations with the major structural protein VP1 of Coxsackie virus B3 (CVB3) have been previously found to protect BALB/c mice from lethal challenge. Here we report that the other CVB3 capsid proteins, VP2, VP3, and VP4, were less effective at preventing CVB3-caused disease. The application of pCMV/VP1 as a va...

journal_title：Antiviral research

authors： Henke A,Zell R,Stelzner A

更新日期：2001-01-01 00:00:00

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the sa...

journal_title：Antiviral research

authors： Luo H,Winkelmann ER,Fernandez-Salas I,Li L,Mayer SV,Danis-Lozano R,Sanchez-Casas RM,Vasilakis N,Tesh R,Barrett AD,Weaver SC,Wang T

更新日期：2018-03-01 00:00:00

abstract：:JNJ63623872 (formerly known as VX-787) is an inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. This interaction blocks the cap-snatching activity of the virus that is essential for virus replication. Previously published work has documented antiviral activity of JNJ63623872 in ...

journal_title：Antiviral research

authors： Smee DF,Barnard DL,Jones SM

更新日期：2016-12-01 00:00:00

abstract：:Nucleic acid polymers (NAPs) block the release of HBsAg from infected hepatocytes. These compounds have been previously shown to have the unique ability to eliminate serum surface antigen in DHBV-infected Pekin ducks and achieve multilog reduction of HBsAg or HBsAg loss in patients with chronic HBV infection and HBV/H...

journal_title：Antiviral research

authors： Schöneweis K,Motter N,Roppert PL,Lu M,Wang B,Roehl I,Glebe D,Yang D,Morrey JD,Roggendorf M,Vaillant A

更新日期：2018-01-01 00:00:00

abstract：:Although canine rabies has been eliminated from industrialized countries, infected dogs remain the primary source of human and livestock exposures in Asia, Africa and much of South America. Human deaths are the most important direct economic impact of canine rabies, followed by livestock losses and the cost of PEP, wh...

journal_title：Antiviral research

authors： Shwiff S,Hampson K,Anderson A

更新日期：2013-05-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the de novo biosynthesis of guanine nucleotide, namely, the conversion of IMP to XMP. The depletion of the intracellular GTP and dGTP pools is the major event occurring in the cells exposed to the inhibitors such as mycophenolic acid. The prese...

journal_title：Antiviral research

authors： Khan M,Dhanwani R,Patro IK,Rao PV,Parida MM

更新日期：2011-01-01 00:00:00

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guilla...

journal_title：Antiviral research

authors： Albulescu IC,Kovacikova K,Tas A,Snijder EJ,van Hemert MJ

更新日期：2017-07-01 00:00:00

abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...

journal_title：Antiviral research

authors： Field HJ

更新日期：1985-06-01 00:00:00

abstract：:Avian influenza A(H6N1) virus is one of the most common viruses isolated from migrating birds and domestic poultry in many countries. The first and only known case of human infection by H6N1 virus in the world was reported in Taiwan in 2013. This led to concern that H6N1 virus may cause a threat to public health. In t...

journal_title：Antiviral research

authors： Yang JR,Chen CY,Kuo CY,Cheng CY,Lee MS,Cheng MC,Yang YC,Wu CY,Wu HS,Liu MT,Hsiao PW

更新日期：2016-02-01 00:00:00

abstract：:Citrusinine-I, a new acridone alkaloid isolated from the root bark of the citrus plant (Rutaceae), exhibited potent activity against herpes simplex virus (HSV) type 1 and type 2 at low concentrations relative to their cytotoxicity; 50% effective concentrations (ED50) of citrusinine-I were 0.56 micrograms/ml and 0.74 m...

journal_title：Antiviral research

authors： Yamamoto N,Furukawa H,Ito Y,Yoshida S,Maeno K,Nishiyama Y

更新日期：1989-08-01 00:00:00

abstract：:Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and antiretrovirals is critical. Here, we u...

journal_title：Antiviral research

authors： Daly MB,Sterling M,Holder A,Dinh C,Nishiura K,Khalil G,García-Lerma JG,Dobard C

更新日期：2020-12-29 00:00:00

abstract：:LY253963, the sodium salt of 1,3,4-thiadiazol-2-ylcyanamide, was evaluated in tissue culture and in cotton rats for toxicity and antiviral efficacy against respiratory syncytial (RSV) and parainfluenza type 3 (PIV3) viruses. The selective index (ratio of the median toxic dose: median efficacious dose) of LY253963 in H...

journal_title：Antiviral research

authors： Wyde PR,Ambrose MW,Meyer HL,Gilbert BE

更新日期：1990-10-01 00:00:00

abstract：:The mammarenavirus Lassa (LASV) is highly prevalent in West Africa where it infects several hundred thousand individuals annually resulting in a high number of Lassa fever (LF) cases, a febrile disease associated with high morbidity and significant mortality. Mounting evidence indicates that the worldwide-distributed ...

journal_title：Antiviral research

authors： Cubitt B,Ortiz-Riano E,Cheng BY,Kim YJ,Yeh CD,Chen CZ,Southall NOE,Zheng W,Martinez-Sobrido L,de la Torre JC

更新日期：2020-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zi...

journal_title：Antiviral research

authors： Cancellieri M,Bassetto M,Widjaja I,van Kuppeveld F,de Haan CA,Brancale A

更新日期：2015-10-01 00:00:00

abstract：:The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transf...

journal_title：Antiviral research

authors： Yang WT,Yang GL,Wang Q,Huang HB,Jiang YL,Shi CW,Wang JZ,Huang KY,Jin YB,Wang CF

更新日期：2017-02-01 00:00:00

abstract：:Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...

journal_title：Antiviral research

authors： Gantlett KE,Weber JN,Sattentau QJ

更新日期：2007-09-01 00:00:00

abstract：:Cyclosporin A (CsA) was assessed for its effect on the production of antiviral activity by human peripheral blood leukocytes (PBL). CsA markedly reduced the production of interferon-gamma (IFN-gamma) in response to stimulation with lectin mitogens, bacterial products, alloantigens, or Epstein-Barr virus (EBV)-transfor...

journal_title：Antiviral research

authors： Abb J,Abb H,Deinhardt F

更新日期：1982-12-01 00:00:00

abstract：:A severe inflammatory immune response with hypercytokinemia occurs in patients hospitalized with severe influenza, such as avian influenza A(H5N1), A(H7N9), and seasonal A(H1N1)pdm09 virus infections. The role of immunomodulatory therapy is unclear as there have been limited published data based on randomized controll...

journal_title：Antiviral research

authors： Hui DS,Lee N,Chan PK,Beigel JH

更新日期：2018-02-01 00:00:00

abstract：:We have previously reported a new class of dendrimers with tryptophan (Trp) residues on the surface that show dual antiviral activities against HIV and enterovirus EV71. The prototype compound of this family is a derivative of pentaerythritol with 12 peripheral Trp groups and trivalent spacer arms. Here a novel series...

journal_title：Antiviral research

authors： Martínez-Gualda B,Sun L,Martí-Marí O,Mirabelli C,Delang L,Neyts J,Schols D,Camarasa MJ,San-Félix A

更新日期：2019-08-01 00:00:00

abstract：:Laninamivir, a potent neuraminidase (NA) inhibitor, is an active metabolite of laninamivir octanoate (code name: CS-8958) which is a long acting NA inhibitor and is commercially available under the brand name Inavir in Japan to complete the treatment of influenza by a single inhalation. It is supposed that the long ac...

journal_title：Antiviral research

authors： Kakuta M,Kubo S,Tanaka M,Tobiume S,Tomozawa T,Yamashita M

更新日期：2013-10-01 00:00:00

abstract：:The reverse transcriptase (RT) of HIV which has been inhibited by the incorporation of AZT into the primer strand is subject to a deblocking reaction by cellular ATP. This reaction yields unblocked primer plus the dinucleoside tetraphosphate, AZTp(4)A. In the present study, we report that AZTp(4)A is an excellent subs...

journal_title：Antiviral research

authors： Pitcher WH 3rd,Kirby TW,DeRose EF,London RE

更新日期：2003-05-01 00:00:00