当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Cidofovir and brincidofovir reduce the pathology caused by systemic infection with human type 5 adenovirus in immunosuppressed Syrian hamsters, while ribavirin is largely ineffective in this model.

Cidofovir and brincidofovir reduce the pathology caused by systemic infection with human type 5 adenovirus in immunosuppressed Syrian hamsters, while ribavirin is largely ineffective in this model.

Abstract：

:There are no drugs approved specifically to treat disseminated adenovirus (Ad) infections in humans. Cidofovir is active against Ad in cell culture, and it is used frequently in the clinic with disseminated infection in pediatric transplant patients; however, controlled clinical studies have not been conducted to prove the anti-Ad efficacy of cidofovir. Brincidofovir, a lipid-linked derivative of cidofovir, which has strong activity against Ad in cell culture and in animal models, is a promising new drug currently in clinical trials. Ribavirin, which has modest activity against some Ad types in cell culture, has been used in the clinic against disseminated Ad, but the efficacy of ribavirin is unknown. In the current study, we have examined the activity of cidofovir, brincidofovir, and ribavirin against disseminated Ad5 infection in the immunosuppressed Syrian hamster model. Hamsters are immunosuppressed by treatment with cyclophosphamide, then infected intravenously with Ad5, leading to disseminated Ad5 infection, especially in the liver. We found that cidofovir and brincidofovir have excellent activity against Ad5 pathology and replication in the liver, even when administered therapeutically starting at 3 days post-challenge with Ad5. Ribavirin did not have anti-Ad5 activity in our model. Our data support the use of cidofovir and brincidofovir in humans for the treatment of disseminated Ad infections in humans.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Tollefson AE,Spencer JF,Ying B,Buller RM,Wold WS,Toth K

doi

10.1016/j.antiviral.2014.10.005

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

38-46

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(14)00285-X

journal_volume

112

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assays.

    abstract：:Human metapneumovirus (hMPV) is a recently elucidated respiratory virus pathogen for which there are no agents currently licensed to prevent or treat infections caused by it. However, NMSO3 has been reported to inhibit replication of human respiratory syncytial virus (hRSV), a virus that is closely related to hMPV, bo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2004.02.006

    authors： Wyde PR,Moylett EH,Chetty SN,Jewell A,Bowlin TL,Piedra PA

    更新日期：2004-07-01 00:00:00

  • Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts.

    abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104752

    authors： Jiang Y,Liu S,Shen S,Guo H,Huang H,Wei W

    更新日期：2020-04-01 00:00:00

  • Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo.

    abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2021.105014

    authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

    更新日期：2021-01-07 00:00:00

  • Antiviral drug susceptibility assays: going with the flow.

    abstract：:This review describes the procedures for the use of fluorochrome labeled monoclonal antibodies and flow cytometry for the detection and quantification of virus infected cells. The application of this technology for (1) identifying virus infected cells in clinical specimens obtained from human cytomegalovirus (HCMV) an...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/s0166-3542(99)00039-x

    authors： McSharry JJ

    更新日期：1999-08-01 00:00:00

  • The ectodomain of rabies virus glycoprotein determines dendritic cell activation.

    abstract：:The immune evasion of wild-type (wt) rabies virus (RABV) has been attributed to its glycoprotein (G), particularly to their inefficiency to bind/enter into dendritic cells (DCs). However, the domain responsible for G-mediated DC activation is not clear. In the present study, attempts were made to map the domain(s) on ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.01.022

    authors： Huang J,Zhang Y,Huang Y,Gnanadurai CW,Zhou M,Zhao L,Fu ZF

    更新日期：2017-05-01 00:00:00

  • Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410.

    abstract：:The 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT)-like compounds with homocyclic moieties at the N-1 of the pyrimidinedione, including the highly potent lead compound IQP-0410, inhibit HIV-1 at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism involving allosteric inhibition at...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.09.005

    authors： Buckheit RW Jr,Watson Buckheit K,Sturdevant CB,Buckheit RW 3rd

    更新日期：2013-11-01 00:00:00

  • Anti-pre-S(2) analysis after hepatitis B vaccination in haemodialysis patients.

    abstract：:We investigated the development of anti-pre-S(2) antibodies by enzyme immunoassay and by Western blot analysis in a vaccination study in haemodialysis patients; both the Pasteur plasma vaccine retaining the pre-S(2) epitopes and the Merck, Sharp and Dohme (MSD) plasma vaccine containing only HBsAg were used. By enzyme...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(89)90071-5

    authors： Heijtink RA,de Wilde GA,Kruining J,Smit-Leijs MB,Schalm SW

    更新日期：1989-09-01 00:00:00

  • Protection of Balb/c mice against infection with FMDV by immunostimulation with CpG oligonucleotides.

    abstract：:Oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are potent stimulators of the innate immune system, and are capable of aborting several infections in a non-specific manner. We here report studies of the capacity of such ODN to protect mice against infection with foot and mouth disease virus (FMDV). Susc...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.03.010

    authors： Kamstrup S,Frimann TH,Barfoed AM

    更新日期：2006-10-01 00:00:00

  • A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1.

    abstract：:The essential role of SMAR1 in HIV-1 transcription and LTR driven gene expression suggests SMAR1 as an HIV dependency factor (HDF) and a potential anti-HIV therapeutic target. Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1. Out of 8...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104648

    authors： Trivedi J,Alam A,Joshi S,Kumar TP,Chippala V,Mainkar PS,Chandrasekhar S,Chattopadhyay S,Mitra D

    更新日期：2020-01-01 00:00:00

  • Effect of imexon treatment on Friend virus complex infection using genetically defined mice as a model for HIV-1 infection.

    abstract：:Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune de...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(91)90040-x

    authors： Morrey JD,Warren RP,Okleberry KM,Burger RA,Chirigos MA,Sidwell RW

    更新日期：1991-01-01 00:00:00

  • An engineered inhibitor RNA that efficiently interferes with hepatitis C virus translation and replication.

    abstract：:Hepatitis C virus (HCV) translation is mediated by a highly conserved internal ribosome entry site (IRES), mainly located at the 5'untranslatable region (5'UTR) of the viral genome. Viral protein synthesis clearly differs from that used by most cellular mRNAs, rendering the IRES an attractive target for novel antivira...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.02.015

    authors： Romero-López C,Berzal-Herranz B,Gómez J,Berzal-Herranz A

    更新日期：2012-05-01 00:00:00

  • T cell responses in hepatitis C virus infection: historical overview and goals for future research.

    abstract：:Hepatitis C virus (HCV)-specific T cells are key factors in the outcome of acute HCV infection and in protective immunity. This review recapitulates the steps that immunologists have taken in the past 25years to dissect the role of T cell responses in HCV infection. It describes technical as well as disease-specific c...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2014.11.009

    authors： Holz L,Rehermann B

    更新日期：2015-02-01 00:00:00

  • Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives.

    abstract：:Several novel γ-carboline derivatives were identified as selective inhibitors of bovine viral diarrhea virus (BVDV) replication in cell cultures. Among them, 3,4,5-trimethyl-γ-carboline (SK3M4M5M) was the most active against BVDV (Nose strain) in MDBK cells, with a 50% effective concentration of 0.017±0.005μM and a se...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.09.013

    authors： Salim MT,Goto Y,Hamasaki T,Okamoto M,Aoyama H,Hashimoto Y,Musiu S,Paeshuyse J,Neyts J,Froeyen M,Herdewijn P,Baba M

    更新日期：2010-12-01 00:00:00

  • Recombinant pseudorabies virus expressing E2 of classical swine fever virus (CSFV) protects against both virulent pseudorabies virus and CSFV.

    abstract：:Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104652

    authors： Tong W,Zheng H,Li GX,Gao F,Shan TL,Zhou YJ,Yu H,Jiang YF,Yu LX,Li LW,Kong N,Tong GZ,Li JC

    更新日期：2020-01-01 00:00:00

  • Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus.

    abstract：:In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A54...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2009.12.010

    authors： Zhiqiang W,Yaowu Y,Fan Y,Jian Y,Yongfeng H,Lina Z,Jianwei W,Qi J

    更新日期：2010-03-01 00:00:00

  • A quantitative method for hepatitis B virus covalently closed circular DNA enables distinguishing direct acting antivirals from cytotoxic agents.

    abstract：:Studying the biogenesis of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and developing anti-HBV agents require analytical methods to quantify viral DNA levels inside host cells. The well-accepted Southern blotting method is only semi-quantitative, while the other widely used methods (based on qPCR) ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.06.002

    authors： Gao Z,Yan L,Li W

    更新日期：2019-08-01 00:00:00

  • Antiviral activity of Viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus.

    abstract：:Viracea, a topical microbicide, is a blend of benzalkonium chloride and phytochemicals derived from Echinacea purpurea and is a proprietary formula from Destiny BioMediX Corp. Viracea was tested against 40 strains of herpes simplex virus (HSV): 15 strains (five HSV-1 and ten HSV-2) were resistant to acyclovir (ACV-R) ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(98)00027-8

    authors： Thompson KD

    更新日期：1998-07-01 00:00:00

  • Lessons from reproductive health to inform multipurpose prevention technologies: don't reinvent the wheel.

    abstract：UNLABELLED:This paper presents the public health rationale for multipurpose prevention technologies (MPTs) for sexual and reproductive health (SRH) based on regional trends in demographic and SRH indicators. It then distils important lessons gleaned from the introduction of contraceptive and reproductive health product...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2013.09.019

    authors： Brady M,Manning J

    更新日期：2013-12-01 00:00:00

  • Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005.

    abstract：:The prevention and control of disease caused by seasonal and potential pandemic influenza viruses is currently managed by the use influenza vaccines and antivirals. The adamantanes (amantadine and rimantadine) were the first antivirals licensed for use against influenza A viruses and have been used extensively in some...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.08.002

    authors： Barr IG,Hurt AC,Iannello P,Tomasov C,Deed N,Komadina N

    更新日期：2007-02-01 00:00:00

  • Altered monocyte response to the dengue virus in those with varying severity of past dengue infection.

    abstract：OBJECTIVE:We sought to investigate the differences in monocyte immune responses to the dengue virus (DENV) in those who previously had either severe disease (past SD) or non-severe dengue (past NSD) following a secondary dengue infection. METHOD:Monocytes from healthy individuals who had either past SD (n = 6) or past...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104554

    authors： Kamaladasa A,Gomes L,Wijesinghe A,Jeewandara C,Toh YX,Jayathilaka D,Ogg GS,Fink K,Malavige GN

    更新日期：2019-09-01 00:00:00

  • Immune response to varicella-zoster virus before and after renal transplantation.

    abstract：BACKGROUND:Herpes zoster (HZ) risk is high in renal transplant recipients. Vaccination prior to transplantation may provide a useful strategy for the prevention of HZ in the posttranplantation period. However, it is not known whether immunity to varicella-zoster virus (VZV) is affected due to treatment surrounding tran...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104938

    authors： Rondaan C,de Joode AAE,Wang L,Siderius M,Raveling-Eelsing E,van Leer-Buter C,van Assen S,Bos NA,Westra J

    更新日期：2020-11-01 00:00:00

  • A dual chicken IgY against rotavirus and norovirus.

    abstract：:Rotavirus (RV) and norovirus (NoV) are the two most important causes of viral gastroenteritis. While vaccine remains an effective prophylactic strategy, development of other approaches, such as passive immunization to control and treat clinical infection and illness of these two pathogens, is necessary. Previously we ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.12.011

    authors： Dai YC,Zhang XF,Tan M,Huang P,Lei W,Fang H,Zhong W,Jiang X

    更新日期：2013-03-01 00:00:00

  • In vitro antiviral activity of polyoxomolybdates. Mechanism of inhibitory effect of PM-104 (NH4)12H2(Eu4(MoO4)(H2O)16(Mo7O24)4).13H2O on human immunodeficiency virus type 1.

    abstract：:A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the che...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(93)90075-t

    authors： Inouye Y,Tokutake Y,Yoshida T,Seto Y,Hujita H,Dan K,Yamamoto A,Nishiya S,Yamase T,Nakamura S

    更新日期：1993-04-01 00:00:00

  • Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection.

    abstract：:Therapeutic strategies controlling human cytomegalovirus (hCMV) infection are limited due to adverse side effects and emergence of antiviral resistance variants. A compound being evaluated for treating hCMV disease is maribavir (MBV) which disrupts replication by inhibiting the viral kinase pUL97. Previous studies hav...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.09.011

    authors： Reitsma JM,Terhune SS

    更新日期：2013-11-01 00:00:00

  • Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: a meta-analysis of randomised trials.

    abstract：BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

    journal_title：Antiviral research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.antiviral.2010.12.003

    authors： Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

    更新日期：2011-02-01 00:00:00

  • Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants.

    abstract：:The ability to control plant viral diseases with chemicals has great potential value for agriculture, but few chemicals are available to date due to the difficulty in obtaining effective drugs. IMP dehydrogenase is an enzyme which catalyzes the conversion of inosine 5'-monophosphate to xanthosine 5'-monophosphate in t...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.10.007

    authors： Panattoni A,D'Anna F,Triolo E

    更新日期：2007-03-01 00:00:00

  • Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates.

    abstract：:Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.05.007

    authors： Ong EZ,Budigi Y,Tan HC,Robinson LN,Rowley KJ,Winnett A,Hobbie S,Shriver Z,Babcock GJ,Ooi EE

    更新日期：2017-08-01 00:00:00

  • Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial.

    abstract：BACKGROUND AND AIMS:Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0166-3542(00)00141-8

    authors： Andreone P,Fiorino S,Cursaro C,Gramenzi A,Margotti M,Di Giammarino L,Biselli M,Miniero R,Gasbarrini G,Bernardi M

    更新日期：2001-02-01 00:00:00

  • Producing physicochemical property consensus alphavirus protein antigens for broad spectrum vaccine design.

    abstract：:There is a pressing need for new vaccines against alphaviruses, which can cause fatal encephalitis (Venezuelan equine encephalitis virus (VEEV) and others) and severe arthralgia (e.g. Chikungunya virus, CHIKV). These positive-strand RNA viruses are diverse and evolve rapidly, meaning that the sequence of any vaccine s...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104905

    authors： Baker WS,Negi S,Braun W,Schein CH

    更新日期：2020-10-01 00:00:00

  • Toxicity and antiviral activity of LY253963 against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats.

    abstract：:LY253963, the sodium salt of 1,3,4-thiadiazol-2-ylcyanamide, was evaluated in tissue culture and in cotton rats for toxicity and antiviral efficacy against respiratory syncytial (RSV) and parainfluenza type 3 (PIV3) viruses. The selective index (ratio of the median toxic dose: median efficacious dose) of LY253963 in H...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90005-r

    authors： Wyde PR,Ambrose MW,Meyer HL,Gilbert BE

    更新日期：1990-10-01 00:00:00