当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants.

Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants.

Abstract：

:The ability to control plant viral diseases with chemicals has great potential value for agriculture, but few chemicals are available to date due to the difficulty in obtaining effective drugs. IMP dehydrogenase is an enzyme which catalyzes the conversion of inosine 5'-monophosphate to xanthosine 5'-monophosphate in the de novo purine nucleotide synthetic pathway, and is considered a sensitive target for antiviral drugs. Two IMPDH inhibitors, tiazofurin (TR) and mycophenolic acid (MPA), were tested for their inhibitory effect on Grapevine leafroll-associated virus 3 (GLRaV-3) in in vitro grapevine explants. TR administration produced plantlets characterized by negative ELISA readings. No PCR products were obtained from these samples. This was confirmed by the absence of viral particles. MPA was essentially ineffective against GLRaV-3 replication in Sangiovese explants. This is the first report of GLRaV-3 eradication in grapevine explants following TR administration.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Panattoni A,D'Anna F,Triolo E

doi

10.1016/j.antiviral.2006.10.007

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

206-11

issue

3

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(06)00314-7

journal_volume

73

pub_type

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