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Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum.

Abstract：

:The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transferring IgG across polarized epithelial cells. In the present study, an oral vaccine was developed using Lactobacillus plantarum to deliver the internal influenza viral protein M2e fused to an IgG Fc fragment. Oral vaccination with recombinant L. plantarum expressing 3M2e-Fc elicited Peyer's patch (PP) DC activation, improved the number of gamma interferon (IFN-γ)-producing T cells and increased the frequency of CD8+IFN-γ+ cells in the mesenteric lymph nodes (MLNs). In addition, the recombinant L. plantarum can induce PP B220+IgA+ expression and enhance specific sIgA secretion and the shaping of growth centers (GCs) in PPs. Furthermore, the data demonstrated that immunization with recombinant L. plantarum expressing 3M2e-Fc markedly reduced the viral load in the lung and protected against H1N1 influenza virus and mouse-adapted H9N2 avian influenza virus (AIV) challenge in BALB/c mice. Collectively, the data also showed that this vaccine strategy provided effective protective immunity against infection with homologous and heterologous influenza viruses in a mouse model and may be useful for future influenza vaccine development.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Yang WT,Yang GL,Wang Q,Huang HB,Jiang YL,Shi CW,Wang JZ,Huang KY,Jin YB,Wang CF

doi

10.1016/j.antiviral.2016.11.025

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

9-21

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(16)30462-4

journal_volume

138

pub_type

杂志文章

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