Abstract：
:JNJ63623872 (formerly known as VX-787) is an inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. This interaction blocks the cap-snatching activity of the virus that is essential for virus replication. Previously published work has documented antiviral activity of JNJ63623872 in cell culture and mouse infection studies. In this report, we extend the in vivo observations by comparing the efficacies of JNJ63623872 and oseltamivir in mice infected with influenza A/California/04/2009 (H1N1pdm) and A/Victoria/3/75 (H3N2) viruses. Animals received JNJ63623872 or oseltamivir orally twice daily for 10 days starting 2 h pre-infection. JNJ63623872 (2, 6, and 20 mg/kg/day) and oseltamivir (20 mg/kg/day) completely prevented death in the H1N1pdm virus infection. Weight loss at nadir was only 12% in mice receiving 2 mg/kg/day of JNJ63623872 compared to 23% and 32%, respectively, in oseltamivir-treated (20 mg/kg/day) and placebo groups. Lung hemorrhage scores, lung weights, and lung virus titers on day 6 were reduced in a dose-responsive manner by JNJ63623872 treatments, whereas oseltamivir treatments were not as effective. JNJ63623872 was less active against H3N2 virus infection, with more body weight loss occurring and only 30% survival at the 2-mg/kg/day dose. Lung scores, lung weights, and H3N2 viral titers in lungs of mice were reduced less by JNJ63623872 treatments compared to the H1N1pdm infection. Nevertheless, the 20-mg/kg/day dose of JNJ63623872 was more effective than oseltamivir (20 mg/kg/day) in improving body weight and reducing the severity of lung infection. JNJ63623872 appears to be an important new drug candidate to treat influenza A H1N1pdm and H3N2 virus infections.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Smee DF,Barnard DL,Jones SMdoi
10.1016/j.antiviral.2016.10.009subject
Has Abstractpub_date
2016-12-01 00:00:00pages
45-50eissn
0166-3542issn
1872-9096pii
S0166-3542(16)30404-1journal_volume
136pub_type
杂志文章abstract：:A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the che...
journal_title：Antiviral research
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abstract：BACKGROUND AND AIMS:Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can...
journal_title：Antiviral research
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 历史文章,杂志文章,评审
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0166-3542(00)00102-9
更新日期：2000-08-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.09.016
更新日期：2012-12-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.05.006
更新日期：2008-10-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(99)00014-5
更新日期：1999-07-01 00:00:00
abstract：:Twenty-four patients with chronic non-A non-B hepatitis were randomly assigned to receive either human fibroblast interferon (HuIFN-beta) at doses of 1 or 3 million international units (MIU) per day for 4 or 12 weeks (12 patients) or to receive no therapy (12 patients), and were then compared with 5 patients with chro...
journal_title：Antiviral research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1989-10-01 00:00:00
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Antiviral research
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更新日期：2010-11-01 00:00:00
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2017.07.016
更新日期：2017-09-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：1993-05-01 00:00:00
abstract：:In the present study, the protective effect of 1T1, a lambda-carrageenan extracted from the red seaweed Gigartina skottsbergii was evaluated in a murine model of herpes simplex virus type 2 (HSV-2) genital infection. Six to eight-week-old female BALB/c mice were intravaginally inoculated with a lethal dose of HSV-2 (M...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.07.001
更新日期：2004-11-01 00:00:00
abstract：:HIV-1 integrase (IN) is one of three essential enzymes (along with reverse transcriptase and protease) encoded by the viral pol gene. IN mediates two critical reactions during viral replication; firstly 3'-end processing (3'EP) of the double-stranded viral DNA ends and then strand transfer (STF) which joins the viral ...
journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.antiviral.2009.11.004
更新日期：2010-01-01 00:00:00
abstract：:Development of anti-dengue therapy represents an urgent un-met medical need. Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led to the possibility of structure-based rational design of inhibitors for anti-dengue therapy. These include (i) the structure of the 'active' form of the...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2012.09.007
更新日期：2012-11-01 00:00:00
