当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Crimean-Congo hemorrhagic fever in Turkey: Current status and future challenges.

Crimean-Congo hemorrhagic fever in Turkey: Current status and future challenges.

Abstract：

:Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mortality rate just under 5%. This article assesses the present epidemiological situation of CCHF in Turkey, with an updated literature review, describes national practices and summarizes lessons learned in preparation for future outbreaks.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Leblebicioglu H,Ozaras R,Irmak H,Sencan I

doi

10.1016/j.antiviral.2015.12.003

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

21-34

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(15)30040-1

journal_volume

126

pub_type

历史文章,杂志文章,评审

相关文献

ANTIVIRAL RESEARCH文献大全
  • Mismatched double-stranded RNA (polyI-polyC(12)U) is synergistic with multiple anti-HIV drugs and is active against drug-sensitive and drug-resistant HIV-1 in vitro.

    abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(01)00150-4

    authors： Essey RJ,McDougall BR,Robinson WE Jr

    更新日期：2001-09-01 00:00:00

  • Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs.

    abstract：:Coxsackievirus B3 (CVB3) is a common pathogen of myocarditis. We previously synthesized a siRNA targeting the CVB3 protease 2A (siRNA/2A) gene and achieved reduction of CVB3 replication by 92% in vitro. However, like other drugs under development, CVB3 siRNA faces a major challenge of targeted delivery. In this study,...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2009.07.005

    authors： Zhang HM,Su Y,Guo S,Yuan J,Lim T,Liu J,Guo P,Yang D

    更新日期：2009-09-01 00:00:00

  • Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development.

    abstract：:The family Flaviviridae comprises several major human pathogens including hepatitis C virus (genus hepacivirus), yellow fever virus, West Nile virus and dengue virus (genus flavivirus). Flaviviridae genomes comprise a single-stranded RNA segment encoding a single polyprotein that is subsequently processed into 10 matu...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2014.02.006

    authors： Caillet-Saguy C,Lim SP,Shi PY,Lescar J,Bressanelli S

    更新日期：2014-05-01 00:00:00

  • Inhibition of HSV-1 and vaccinia virus replication by cephalosporin derivatives.

    abstract：:Derivatives of beta-lactam antibiotics of the cephalosporin type at 0.02-1 mM concentrations interfered with in vitro replication of two DNA-containing viruses, herpes simplex I and vaccinia, but showed no effects on two RNA-viruses, lymphocytic choriomeningitis virus and vesicular stomatitis virus, or on cell viabili...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(88)90014-9

    authors： Cottagnoud P,Neftel KA,Hany M,Zinkernagel RM

    更新日期：1988-11-01 00:00:00

  • Inhibition of respiratory syncytial virus in cultured cells by nucleocapsid gene targeted deoxyribozyme (DNAzyme).

    abstract：:Respiratory syncytial virus (RSV), which presents the primary cause of bronchiolitis and pneumonia among infants and causes significant morbidity and mortality in immunodeficient patients, remains a health problem worldwide. Unfortunately, an effective vaccine is currently unavailable and pharmacologic treatment needs...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.02.011

    authors： Xie YY,Zhao XD,Jiang LP,Liu HL,Wang LJ,Fang P,Shen KL,Xie ZD,Wu YP,Yang XQ

    更新日期：2006-08-01 00:00:00

  • SAMHD1 is active in cycling cells permissive to HIV-1 infection.

    abstract：:SAMHD1 is a triphosphohydrolase that restricts HIV-1 by limiting the intracellular dNTP pool required for reverse transcription. Although SAMHD1 is expressed and active/unphosphorylated in most cell lines, its restriction activity is thought to be relevant only in non-cycling cells. However, an in depth evaluation of ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.03.019

    authors： Badia R,Pujantell M,Torres-Torronteras J,Menéndez-Arias L,Martí R,Ruzo A,Pauls E,Clotet B,Ballana E,Esté JA,Riveira-Muñoz E

    更新日期：2017-06-01 00:00:00

  • Molecular basis of antagonism between K70E and K65R tenofovir-associated mutations in HIV-1 reverse transcriptase.

    abstract：:The K70E mutation in HIV-1 reverse transcriptase was observed in 10% of virologic non-responders of the abacavir/lamivudine/tenofovir arm of ESS30009, alone, or in mixtures with K65R by population sequencing. Clonal analysis of six ESS30009 K70E isolates failed to identify double mutants carrying K65R+K70E. Site-direc...

    journal_title：Antiviral research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.antiviral.2007.03.006

    authors： Kagan RM,Lee TS,Ross L,Lloyd RM Jr,Lewinski MA,Potts SJ

    更新日期：2007-09-01 00:00:00

  • In vitro anti-influenza A activity of interferon (IFN)-λ1 combined with IFN-β or oseltamivir carboxylate.

    abstract：:Influenza viruses, which can cross species barriers and adapt to new hosts, pose a constant potential threat to human health. The influenza pandemic of 2009 highlighted the rapidity with which an influenza virus can spread worldwide. Currently available antivirals have a number of limitations against influenza, and no...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.09.008

    authors： Ilyushina NA,Donnelly RP

    更新日期：2014-11-01 00:00:00

  • Semi-quantitative detection of viral RNA in influenza A virus-infected mice for evaluation of antiviral compounds.

    abstract：:The aim of the study was to establish a murine model for sensitive screening of potential compounds with in vitro anti-influenza A virus activity. The evaluation in this in vivo model is based on semi-quantitative detection of viral RNA using one-step reverse transcriptase polymerase chain reaction (RT-PCR). After int...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(02)00184-5

    authors： Sauerbrei A,Ulbricht A,Wutzler P

    更新日期：2003-03-01 00:00:00

  • Germacrone inhibits early stages of influenza virus infection.

    abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.09.021

    authors： Liao Q,Qian Z,Liu R,An L,Chen X

    更新日期：2013-12-01 00:00:00

  • Long-chain fatty acyl-coenzyme A suppresses hepatitis C virus infection by targeting virion-bound lipoproteins.

    abstract：:Hepatitis C virus (HCV) is a leading cause of chronic hepatitis and end-stage liver diseases. Mature HCV virions are bound by host-derived lipoproteins. Lack of an HCV vaccine warrants a major role of antiviral treatment in the global elimination of hepatitis C. Although direct-acting antivirals (DAAs) are replacing t...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104734

    authors： Li X,Li J,Feng Y,Cai H,Li YP,Peng T

    更新日期：2020-05-01 00:00:00

  • A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1.

    abstract：:Sequences from the gag, pol and rev regions of the RF strain of HIV-1 (HIV-1RF) were chosen as targets for antisense phosphorothioate oligodeoxynucleotides (S-oligos). These sequences were the p18/p24 junction in gag, the active site of HIV protease in pol; a sequence from the first exon of the rev gene and S-oligodeo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(92)90090-r

    authors： Kinchington D,Galpin S,Jaroszewski JW,Ghosh K,Subasinghe C,Cohen JS

    更新日期：1992-01-01 00:00:00

  • Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy.

    abstract：:Lentiviral vectors have been shown to be good candidates for gene transfer protocols; however, prevention of insertional mutagenesis remains problematic. Here we report on the design of a conditionally replicating integrase (IN)-defective lentiviral-hybrid episomal vector in which the insertion of the SV40 promoter/or...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2008.06.015

    authors： Vargas J Jr,Klotman ME,Cara A

    更新日期：2008-12-01 00:00:00

  • Immunogenicity and protective efficacy of recombinant major envelope protein (rH3L) of buffalopox virus in animal models.

    abstract：:Buffalopox virus, a zoonotic Indian vaccinia-like virus, is responsible for contagious disease affecting mainly buffaloes, cattle and humans. H3L gene, encoding for an immunodominant major envelope protein of intracellular mature virion of orthopoxviruses, is highly conserved and found to elicit neutralizing antibodie...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.12.004

    authors： Kumar A,Yogisharadhya R,Venkatesan G,Bhanuprakash V,Shivachandra SB

    更新日期：2016-02-01 00:00:00

  • Antiviral activity of tiazofurine against barley stripe mosaic virus.

    abstract：:Tiazofurine (2-beta-D-ribofuranosylthiazole-4-carboxamide) was found to inhibit replication of barley stripe mosaic virus (BSMV) in barley and wheat plants. Treatment with this nucleoside analogue delayed and inhibited symptom development and suppressed virus multiplication. The most effective concentration applied tw...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(89)90019-3

    authors： Nagy PD,Gáborjányi R,Kovács L,Farkas I

    更新日期：1989-02-01 00:00:00

  • Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.

    abstract：:Antiviral medication is used for the treatment of severe influenza infections, of which the neuraminidase inhibitors (NAIs) are the most effective drugs, approved so far. Here, we investigated the antiviral efficacy of the peptidomimetic furin inhibitor MI-701 in combination with oseltamivir carboxylate and ribavirin ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.05.006

    authors： Lu Y,Hardes K,Dahms SO,Böttcher-Friebertshäuser E,Steinmetzer T,Than ME,Klenk HD,Garten W

    更新日期：2015-08-01 00:00:00

  • Inhibition of avian myeloblastosis virus reverse transcriptase and virus inactivation by metal complexes of isonicotinic acid hydrazide.

    abstract：:The cupric and ferric complexes of isonicotinic acid hydrazide (INH) inhibit the DNA synthesis catalysed by avian myeloblastosis virus (AMV) reverse transcriptase. The inhibition was to the extent of 95% by 50 microM of cupric-INH complex and 55% by 100 microM of ferric-INH complex. These complexes have been found to ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(82)90052-3

    authors： Vasudevachari MB,Antony A

    更新日期：1982-10-01 00:00:00

  • Baicalin inhibits autophagy induced by influenza A virus H3N2.

    abstract：:Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in b...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.11.003

    authors： Zhu HY,Han L,Shi XL,Wang BL,Huang H,Wang X,Chen DF,Ju DW,Feng MQ

    更新日期：2015-01-01 00:00:00

  • Evidence that the amino acid region 124-203 of glycoprotein G from the respiratory syncytial virus (RSV) constitutes a major part of the polypeptide domain that is involved in the protection against RSV infection.

    abstract：:The first 230 residues of the 298-amino acid glycoprotein G of respiratory syncytial virus (RSV) are sufficient to confer complete resistance to challenge with live RSV, whereas the first 180 residues completely failed (Olmsted et al. (1989) J. Virol. 63, 411-420). The characterization of a protective epitope correspo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(95)00053-4

    authors： Simard C,Nadon F,Séguin C,Trudel M

    更新日期：1995-12-01 00:00:00

  • Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C.

    abstract：:The viral genotype and serum viral level influence the response to interferon (IFN) treatment in patients with chronic hepatitis C virus (HCV) viremia. The aim of this study was to investigate a possible relationship between early virological response and helper T (Th) cell cytokine expansion by 4 weeks of ribavirin (...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.antiviral.2005.04.001

    authors： Furusyo N,Kubo N,Toyoda K,Takeoka H,Nabeshima S,Murata M,Nakamuta M,Hayashi J

    更新日期：2005-07-01 00:00:00

  • Suppression of BK virus replication and cytopathic effect by inhibitors of prokaryotic DNA gyrase.

    abstract：:Nalidixic acid and oxolinic acid, two antibacterial agents known to inhibit bacterial DNA gyrase, are shown to suppress the replication, as well as the cytopathic effect, of BK virus in Vero cell cultures. The inhibition of virus replication was detectable at day 4 post infection in cultures which had been continuousl...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(88)90004-6

    authors： Portolani M,Pietrosemoli P,Cermelli C,Mannini-Palenzona A,Grossi MP,Paolini L,Barbanti-Brodano G

    更新日期：1988-04-01 00:00:00

  • The cumulative occurrence of resistance mutations in the HIV-1 protease gene is associated with failure of salvage therapy with ritonavir and saquinavir in protease inhibitor-experienced patients.

    abstract：:Salvage therapy with ritonavir (RTV) and saquinavir (SQV) failed to achieve virological and immunological improvement in 24 HIV-infected patients who discontinued triple therapy with RTV or indinavir (IDV) because of failure or intolerance to treatment. Changes in the HIV-1 protease gene sequence were analyzed prospec...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0166-3542(00)00110-8

    authors： Karmochkine M,Si Mohamed A,Piketty C,Ginsburg C,Raguin G,Schneider-Fauveau V,Gutmann L,Kazatchkine MD,Belec L

    更新日期：2000-09-01 00:00:00

  • Protection of a novel epitope-RNA VLP double-effective VLP vaccine for foot-and-mouth disease.

    abstract：:Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. Previously, we found that the epitope peptide EP141-160 displayed on virus-like particles (VLP) for use as a vaccine showed high immunoreactivity and conferred partially effective protection to animals. In this study, we first ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.08.020

    authors： Dong YM,Cai JC,Chen HT,Chen L

    更新日期：2016-10-01 00:00:00

  • Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.

    abstract：:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly ass...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0166-3542(95)00921-3

    authors： Jabs DA

    更新日期：1996-01-01 00:00:00

  • Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial.

    abstract：BACKGROUND AND AIMS:Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0166-3542(00)00141-8

    authors： Andreone P,Fiorino S,Cursaro C,Gramenzi A,Margotti M,Di Giammarino L,Biselli M,Miniero R,Gasbarrini G,Bernardi M

    更新日期：2001-02-01 00:00:00

  • Antiviral activity of brincidofovir on parvovirus B19.

    abstract：:Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus responsible for a wide range of clinical manifestations. Currently there is no approved antiviral therapy for parvovirus infection. The acyclic nucleoside phosphonate cidofovir (CDV) has been demonstrated to inhi...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.12.003

    authors： Bua G,Conti I,Manaresi E,Sethna P,Foster S,Bonvicini F,Gallinella G

    更新日期：2019-02-01 00:00:00

  • Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice.

    abstract：:Anti-herpes simplex virus (HSV) activities of oxyresveratrol in vitro and topical administration in cutaneous HSV-1 infection in mice were examined. The inhibitory concentrations for 50% plaque formation (IC(50)) of oxyresveratrol against HSV-1 clinical isolates and HSV-2 clinical isolates were 20.9-29.5 and 22.2-27.5...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.05.013

    authors： Lipipun V,Sasivimolphan P,Yoshida Y,Daikoku T,Sritularak B,Ritthidej G,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

    更新日期：2011-08-01 00:00:00

  • Functional significance of amino acid residues within conserved hydrophilic regions in human interferons-alpha.

    abstract：:Site-directed in vitro mutagenesis was used to create analogs of human interferons (IFNs)-alpha 1 and -alpha 4. Analogs were expressed in vitro using SP6 RNA polymerase and a rabbit reticulocyte lysate cell-free protein synthesis system. Amino acid substitutions for the highly conserved residues at positions 33, 121, ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(89)90066-1

    authors： Tymms MJ,McInnes B,Waine GJ,Cheetham BF,Linnane AW

    更新日期：1989-08-01 00:00:00

  • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan.

    abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.06.003

    authors： Dapat C,Kondo H,Dapat IC,Baranovich T,Suzuki Y,Shobugawa Y,Saito K,Saito R,Suzuki H

    更新日期：2013-09-01 00:00:00

  • Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses.

    abstract：:Infection with Junín virus (JUNV) is currently being effectively managed in the endemic region using a combination of targeted vaccination and plasma therapy. However, the long-term sustainability of plasma therapy is unclear and similar resources are not available for other New World arenaviruses. As a result, there ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.07.009

    authors： Dunham EC,Leske A,Shifflett K,Watt A,Feldmann H,Hoenen T,Groseth A

    更新日期：2018-09-01 00:00:00