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Inhibition of avian myeloblastosis virus reverse transcriptase and virus inactivation by metal complexes of isonicotinic acid hydrazide.

Abstract：

:The cupric and ferric complexes of isonicotinic acid hydrazide (INH) inhibit the DNA synthesis catalysed by avian myeloblastosis virus (AMV) reverse transcriptase. The inhibition was to the extent of 95% by 50 microM of cupric-INH complex and 55% by 100 microM of ferric-INH complex. These complexes have been found to bind preferentially to the enzyme than to the template-primer. Kinetic analysis showed that the cupric-INH complex is a non-competitive inhibitor with respect to dTTP. The time course of inhibition has revealed that the complexes are inhibitory even after the initiation of polynucleotide synthesis. In vivo toxicity studies in 1-day-old chicks have shown that the complexes are not toxic up to a concentration of 500 microgram per chick. Infection of the 1-day-old chicks with AMV pretreated with 150 microgram of either of the complexes prevented symptoms of leukemia due to virus inactivation.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Vasudevachari MB,Antony A

doi

10.1016/0166-3542(82)90052-3

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

291-300

issue

5

eissn

0166-3542

issn

1872-9096

pii

0166-3542(82)90052-3

journal_volume

2

pub_type

杂志文章

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