Abstract：
:We established a sensitive and accurate method for screening of anti-adenovirus agents using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. MKN-28 cells, which are well-differentiated stomach adenocarcinoma cells, were used for adenovirus (ADV) infection and examined for the anti-ADV activities of several established anti-herpes virus agents. ADV-11 is the causative agent of respiratory and urinary infections. It frequently causes hemorrhagic cystitis in immunocompromised hosts. One laboratory strain and 4 clinical isolates of ADV-11 were examined, and found susceptible (in order of decreasing activity) to 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (S-2242), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine[(S)-HPMPA ], and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine[(S)-HPMPC++ +]. On the other hand, ganciclovir and iododeoxyuridine were only weakly effective and dextran sulfate was ineffective. Our findings indicate that the MTT assay using MKN-28 cells is applicable to anti-ADV screening. The anti-ADV activity of (S)-HPMPA and (S)-HPMPC was confirmed, and, furthermore, S-2242 emerged as a highly potent and selective inhibitor of ADV-11.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Kodama E,Shigeta S,Suzuki T,De Clercq Edoi
10.1016/0166-3542(96)06966-5subject
Has Abstractpub_date
1996-07-01 00:00:00pages
159-64issue
3eissn
0166-3542issn
1872-9096pii
0166354296069665journal_volume
31pub_type
杂志文章abstract：:Itraconazole (ITZ) is a well-known, FDA-approved antifungal drug that is also in clinical trials for its anticancer activity. ITZ exerts its anticancer activity through several disparate targets and pathways. ITZ inhibits angiogenesis by hampering the functioning of the vascular endothelial growth receptor 2 (VEGFR2) ...
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journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
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journal_title：Antiviral research
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.03.004
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pub_type： 杂志文章
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更新日期：1983-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.02.015
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2017.04.002
更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.04.017
更新日期：2013-08-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.08.020
更新日期：2016-10-01 00:00:00
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doi：10.1016/j.antiviral.2010.08.013
更新日期：2010-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：1998-12-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(90)90067-h
更新日期：1990-05-01 00:00:00
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journal_title：Antiviral research
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更新日期：2021-01-25 00:00:00
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更新日期：2011-03-01 00:00:00
