Effect of cyclosporin A on the production of interferon by human peripheral blood leukocytes in vitro.

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the sa...

journal_title：Antiviral research

authors： Luo H,Winkelmann ER,Fernandez-Salas I,Li L,Mayer SV,Danis-Lozano R,Sanchez-Casas RM,Vasilakis N,Tesh R,Barrett AD,Weaver SC,Wang T

更新日期：2018-03-01 00:00:00

abstract：:We have analyzed a panel of protein kinase inhibitors (PKIs) and found that some indolocarbazoles (Gö6976, K252a, K252c) proved to be highly effective inhibitors of GCV-sensitive and -resistant human cytomegalovirus (HCMV) strains, but did not show any effect against herpes simplex virus. Antiviral activity was determ...

journal_title：Antiviral research

authors： Zimmermann A,Wilts H,Lenhardt M,Hahn M,Mertens T

更新日期：2000-10-01 00:00:00

abstract：:Lack of vaccines and efficient control measures complicate the control and eradication of African swine fever (ASF). Limitations of conventional inactivated and attenuated virus-based vaccines against African swine fever virus (ASFV) highlight the need to use new technologies to develop efficient and safe vaccines aga...

journal_title：Antiviral research

authors： Argilaguet JM,Pérez-Martín E,López S,Goethe M,Escribano JM,Giesow K,Keil GM,Rodríguez F

更新日期：2013-04-01 00:00:00

abstract：:Cats infected with molecularly cloned FeLV-FAIDS develop an immunodeficiency syndrome characterized by persistent antigenemia, decline in circulating CD4+ T lymphocytes, and impaired T-cell-dependent immune responses and opportunistic infection. We evaluated the capacity of PMEA to inhibit the replication of FeLV-FAID...

journal_title：Antiviral research

authors： Hoover EA,Ebner JP,Zeidner NS,Mullins JI

更新日期：1991-07-01 00:00:00

abstract：DESIGN:The HIV latent CD4+ T cell reservoir is broadly recognized as a barrier to HIV cure. Induction of HIV expression using protein kinase C (PKC) agonists is one approach under investigation for reactivation of latently infected CD4+ T cells (Beans et al., 2013; Abreu et al., 2014; Jiang et al., 2014; Jiang and Dand...

journal_title：Antiviral research

authors： Vemula SV,Maxwell JW,Nefedov A,Wan BL,Steve J,Newhard W,Sanchez RI,Tellers D,Barnard RJ,Blair W,Hazuda D,Webber AL,Howell BJ

更新日期：2017-03-01 00:00:00

abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

journal_title：Antiviral research

authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

更新日期：1994-05-01 00:00:00

abstract：:Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identificatio...

journal_title：Antiviral research

authors： Prichard MN,Kern ER

更新日期：2012-05-01 00:00:00

abstract：:Coxsackievirus A16 (CA16) is one of the main causative agents of hand, foot and mouth disease (HFMD), which is a common infectious disease in children. CA16 infection may lead to severe nervous system damage and even death in humans. However, study of the pathogenesis of CA16 infection and development of vaccines and ...

journal_title：Antiviral research

authors： Liu Q,Shi J,Huang X,Liu F,Cai Y,Lan K,Huang Z

更新日期：2014-05-01 00:00:00

abstract：:Cellular immune responses (T cell responses) during hepatitis C virus (HCV) infection are significant factors for determining the outcome of infection. HCV adapts to host immune responses by inducing mutations in its genome at specific sites that are important for HLA processing/presentation. Moreover, HCV also adapts...

journal_title：Antiviral research

authors： Ikram A,Obaid A,Awan FM,Hanif R,Naz A,Paracha RZ,Ali A,Janjua HA

更新日期：2017-01-01 00:00:00

abstract：:We studied susceptibility to herpes labialis by exposing 20 volunteers to experimental ultraviolet radiation (UVR) on three occasions at 3- to 4-month intervals. The number of patients who developed lesions after each session was 9/20 (45%), 9/20 (45%) and 14/20 (70%). Herpes simplex virus (HSV) was isolated from 21/2...

journal_title：Antiviral research

authors： Spruance SL,Kriesel JD,Evans TG,McKeough MB

更新日期：1995-09-01 00:00:00

abstract：:Citrusinine-I, a new acridone alkaloid isolated from the root bark of the citrus plant (Rutaceae), exhibited potent activity against herpes simplex virus (HSV) type 1 and type 2 at low concentrations relative to their cytotoxicity; 50% effective concentrations (ED50) of citrusinine-I were 0.56 micrograms/ml and 0.74 m...

journal_title：Antiviral research

authors： Yamamoto N,Furukawa H,Ito Y,Yoshida S,Maeno K,Nishiyama Y

更新日期：1989-08-01 00:00:00

abstract：:The replication efficiency and multi-organ dissemination of some influenza A (H5N1) viruses requires a rapid re-evaluation of the available antiviral strategies. We assessed five regimens of the neuraminidase (NA) inhibitor peramivir in mice inoculated with H5N1 virus. The regimens differed by: (1) frequency of admini...

journal_title：Antiviral research

authors： Boltz DA,Ilyushina NA,Arnold CS,Babu YS,Webster RG,Govorkova EA

更新日期：2008-11-01 00:00:00

abstract：:The mammarenavirus Lassa (LASV) is highly prevalent in West Africa where it infects several hundred thousand individuals annually resulting in a high number of Lassa fever (LF) cases, a febrile disease associated with high morbidity and significant mortality. Mounting evidence indicates that the worldwide-distributed ...

journal_title：Antiviral research

authors： Cubitt B,Ortiz-Riano E,Cheng BY,Kim YJ,Yeh CD,Chen CZ,Southall NOE,Zheng W,Martinez-Sobrido L,de la Torre JC

更新日期：2020-01-01 00:00:00

abstract：:The era of antiviral chemotherapy started more than 50 years with the findings by Domagk and his colleagues that thiosemicarbazones showed activity against vaccinia virus. One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. With the successful implementation of the smallpox vacci...

journal_title：Antiviral research

authors： Neyts J,De Clercq E

更新日期：2003-01-01 00:00:00

abstract：:The antiviral effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, was investigated using mice infected with influenza virus. TJ-41 was found to increase the survival rate, prolong the mean survival days, suppress viral growth in bronchoalveolar labage fluid (BALF) and inhibit the lung index (lung consolidatio...

journal_title：Antiviral research

authors： Mori K,Kido T,Daikuhara H,Sakakibara I,Sakata T,Shimizu K,Amagaya S,Sasaki H,Komatsu Y

更新日期：1999-12-15 00:00:00

abstract：:The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of...

journal_title：Antiviral research

authors： Andrei G,Carter K,Janeba Z,Sampath A,Schang LM,Tarbet EB,Vere Hodge RA,Bray M,Esté JA

更新日期：2017-09-01 00:00:00

abstract：:Salvage therapy with ritonavir (RTV) and saquinavir (SQV) failed to achieve virological and immunological improvement in 24 HIV-infected patients who discontinued triple therapy with RTV or indinavir (IDV) because of failure or intolerance to treatment. Changes in the HIV-1 protease gene sequence were analyzed prospec...

journal_title：Antiviral research

authors： Karmochkine M,Si Mohamed A,Piketty C,Ginsburg C,Raguin G,Schneider-Fauveau V,Gutmann L,Kazatchkine MD,Belec L

更新日期：2000-09-01 00:00:00

abstract：:Infection with the oncogenic γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) cause several severe malignancies in humans. Inhibition of the lytic replication of EBV and KSHV eliminates the reservoir of persistent infection and transmission, consequently preventing the occurr...

journal_title：Antiviral research

authors： Huang L,Yang M,Yuan Y,Li X,Kuang E

更新日期：2017-02-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:In the event of a bioterror attack with variola virus (smallpox), exposure may only be identified following onset of fever. To determine if antiviral therapy with brincidofovir (BCV; CMX001) initiated at, or following, onset of fever could prevent severe illness and death, a lethal rabbitpox model was used. BCV is in ...

journal_title：Antiviral research

authors： Grossi IM,Foster SA,Gainey MR,Krile RT,Dunn JA,Brundage T,Khouri JM

更新日期：2017-07-01 00:00:00

abstract：:Human cytomegalovirus infection can lead to life-threatening clinical manifestations particularly in the immunocompromised host. Current therapy options face severe limitations leading to a continued search for alternative drug candidates. Viral replication is dependent on a balanced interaction between viral and cell...

journal_title：Antiviral research

authors： Hutterer C,Wandinger SK,Wagner S,Müller R,Stamminger T,Zeitträger I,Godl K,Baumgartner R,Strobl S,Marschall M

更新日期：2013-08-01 00:00:00

abstract：:Therapeutic strategies controlling human cytomegalovirus (hCMV) infection are limited due to adverse side effects and emergence of antiviral resistance variants. A compound being evaluated for treating hCMV disease is maribavir (MBV) which disrupts replication by inhibiting the viral kinase pUL97. Previous studies hav...

journal_title：Antiviral research

authors： Reitsma JM,Terhune SS

更新日期：2013-11-01 00:00:00

abstract：:In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB...

journal_title：Antiviral research

authors： Giannecchini S,Wise HM,Digard P,Clausi V,Del Poggetto E,Vesco L,Puzelli S,Donatelli I,Azzi A

更新日期：2011-10-01 00:00:00

abstract：:Oxyresveratrol, a major compound purified from Artocarpus lakoocha, a Thai traditional medicinal plant, was evaluated for its mechanism of action and therapeutic efficacy on cutaneous herpes simplex virus (HSV) infection in mice. The inhibitory concentrations for 50% HSV-1 plaque formation of oxyresveratrol, three cli...

journal_title：Antiviral research

authors： Chuanasa T,Phromjai J,Lipipun V,Likhitwitayawuid K,Suzuki M,Pramyothin P,Hattori M,Shiraki K

更新日期：2008-10-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) has a poor prognosis owing to its intrinsic resistance to chemotherapy. Although zidovudine (AZT) and alpha interferon (IFN-alpha) give rise to some response and improve the prognosis of ATLL, alternative therapies are nee...

journal_title：Antiviral research

authors： Heraud JM,Mortreux F,Merien F,Contamin H,Mahieux R,Pouliquen JF,Wattel E,Gessain A,de Thé H,Bazarbachi A,Hermine O,Kazanji M

更新日期：2006-07-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00

abstract：:The 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT)-like compounds with homocyclic moieties at the N-1 of the pyrimidinedione, including the highly potent lead compound IQP-0410, inhibit HIV-1 at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism involving allosteric inhibition at...

journal_title：Antiviral research

authors： Buckheit RW Jr,Watson Buckheit K,Sturdevant CB,Buckheit RW 3rd

更新日期：2013-11-01 00:00:00

abstract：:Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in b...

journal_title：Antiviral research

authors： Zhu HY,Han L,Shi XL,Wang BL,Huang H,Wang X,Chen DF,Ju DW,Feng MQ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given or...

journal_title：Antiviral research

authors： Lawitz E,Godofsky E,Rouzier R,Marbury T,Nguyen T,Ke J,Huang M,Praestgaard J,Serra D,Evans TG

更新日期：2011-03-01 00:00:00

abstract：:Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of ...

journal_title：Antiviral research

authors： Kneidinger D,Ibrišimović M,Lion T,Klein R

更新日期：2012-06-01 00:00:00