Highlights of the 30th International Conference on Antiviral Research.

abstract：:In vitro studies of HBV core promoter mutations in hepatoma cell lines suggest that some mutations in core promoter transcription factor binding sites result in reduced core promoter activity and viral replication. We sought to validate this hypothesis using clinical samples with viral load differences before and afte...

journal_title：Antiviral research

authors： Cheng Y,Seet BL,Ong CS,Wasser S,Tan TM,Peter FJ,Lim SG

更新日期：2006-03-01 00:00:00

abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

journal_title：Antiviral research

authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

更新日期：1994-05-01 00:00:00

abstract：:We established a sensitive and accurate method for screening of anti-adenovirus agents using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. MKN-28 cells, which are well-differentiated stomach adenocarcinoma cells, were used for adenovirus (ADV) infection and examined for the anti-ADV act...

journal_title：Antiviral research

authors： Kodama E,Shigeta S,Suzuki T,De Clercq E

更新日期：1996-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a major cause of chronic liver diseases such as steatosis, cirrhosis, and hepatocellular carcinoma. HCV particles have been found to associate with apolipoproteins, and apolipoproteins not only participate in the HCV life cycle, but also help HCV escape recognition by the host immu...

journal_title：Antiviral research

authors： Cai H,Yao W,Huang J,Xiao J,Chen W,Hu L,Mai R,Liang M,Chen D,Jiang N,Zhou L,Peng T

更新日期：2020-05-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South...

journal_title：Antiviral research

authors： Couderc T,Lecuit M

更新日期：2015-09-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:Sequences from the gag, pol and rev regions of the RF strain of HIV-1 (HIV-1RF) were chosen as targets for antisense phosphorothioate oligodeoxynucleotides (S-oligos). These sequences were the p18/p24 junction in gag, the active site of HIV protease in pol; a sequence from the first exon of the rev gene and S-oligodeo...

journal_title：Antiviral research

authors： Kinchington D,Galpin S,Jaroszewski JW,Ghosh K,Subasinghe C,Cohen JS

更新日期：1992-01-01 00:00:00

abstract：:There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infect...

journal_title：Antiviral research

authors： Laufer N,Abusamra L,Bolcic F,Gun A,Rolón MJ,Pérez H,Krolewiecki A,Salomón H,Quarleri J,Cahn P

更新日期：2011-12-01 00:00:00

abstract：:Oligodeoxynucleotides (ODNs) composed entirely of deoxyguanosine and thymidine, but not specifically designed to act as antisense agents, were able to significantly inhibit herpes simplex virus growth in acute infection assay systems. The guanosine/thymidine (GT) ODNs which demonstrated this antiviral activity contain...

journal_title：Antiviral research

authors： Fennewald SM,Mustain S,Ojwang J,Rando RF

更新日期：1995-01-01 00:00:00

abstract：:The viral genotype and serum viral level influence the response to interferon (IFN) treatment in patients with chronic hepatitis C virus (HCV) viremia. The aim of this study was to investigate a possible relationship between early virological response and helper T (Th) cell cytokine expansion by 4 weeks of ribavirin (...

journal_title：Antiviral research

authors： Furusyo N,Kubo N,Toyoda K,Takeoka H,Nabeshima S,Murata M,Nakamuta M,Hayashi J

更新日期：2005-07-01 00:00:00

abstract：:Several pyrophosphate analogues have been studied for their effects on avian myeloblastosis virus reverse transcriptase and on cellular DNA polymerase alpha. Examination of structure-activity relationships for these compounds revealed that two acidic groups connected by a short bridge were necessary, but not sufficien...

journal_title：Antiviral research

authors： Eriksson B,Stening G,Oberg B

更新日期：1982-05-01 00:00:00

abstract：:With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational intravenous drug peramivir, and in combination treatments. In this study, we determined the impact of oseltamiv...

journal_title：Antiviral research

authors： Bantia S,Upshaw R,Babu YS

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can...

journal_title：Antiviral research

authors： Andreone P,Fiorino S,Cursaro C,Gramenzi A,Margotti M,Di Giammarino L,Biselli M,Miniero R,Gasbarrini G,Bernardi M

更新日期：2001-02-01 00:00:00

abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...

journal_title：Antiviral research

authors： Field HJ

更新日期：1985-06-01 00:00:00

abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients. Immunosuppressants used to prevent alloreactivity can also interfere with virus infection, but the direct effects of the specific type of immunosuppressants on rotavirus infection are still unclear. Here we prof...

journal_title：Antiviral research

authors： Yin Y,Wang Y,Dang W,Xu L,Su J,Zhou X,Wang W,Felczak K,van der Laan LJ,Pankiewicz KW,van der Eijk AA,Bijvelds M,Sprengers D,de Jonge H,Koopmans MP,Metselaar HJ,Peppelenbosch MP,Pan Q

更新日期：2016-09-01 00:00:00

abstract：:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylami...

journal_title：Antiviral research

authors： Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

更新日期：1990-09-01 00:00:00

abstract：:Salvage therapy with ritonavir (RTV) and saquinavir (SQV) failed to achieve virological and immunological improvement in 24 HIV-infected patients who discontinued triple therapy with RTV or indinavir (IDV) because of failure or intolerance to treatment. Changes in the HIV-1 protease gene sequence were analyzed prospec...

journal_title：Antiviral research

authors： Karmochkine M,Si Mohamed A,Piketty C,Ginsburg C,Raguin G,Schneider-Fauveau V,Gutmann L,Kazatchkine MD,Belec L

更新日期：2000-09-01 00:00:00

abstract：:Favipiravir (T-705) is a new anti-influenza drug approved for human use in Japan and progressing through Phase 3 clinical trials in the U.S. In addition to its potent inhibitory effects against influenza virus infection, the compound has been shown to be broadly active against RNA viruses from 9 different families, in...

journal_title：Antiviral research

authors： Gowen BB,Sefing EJ,Westover JB,Smee DF,Hagloch J,Furuta Y,Hall JO

更新日期：2015-09-01 00:00:00

abstract：:On the basis of three different models (namely: ddU, AZT and PMEA), mononucleotide phosphotriester derivatives were designed to be able to liberate the corresponding monophosphate (or phosphonate) inside the cell through a reductase-mediated activation process. It was demonstrated that the use of bis[S-(2-hydroxyethyl...

journal_title：Antiviral research

authors： Puech F,Gosselin G,Lefebvre I,Pompon A,Aubertin AM,Kirn A,Imbach JL

更新日期：1993-10-01 00:00:00

abstract：:In the present study, the protective effect of 1T1, a lambda-carrageenan extracted from the red seaweed Gigartina skottsbergii was evaluated in a murine model of herpes simplex virus type 2 (HSV-2) genital infection. Six to eight-week-old female BALB/c mice were intravaginally inoculated with a lethal dose of HSV-2 (M...

journal_title：Antiviral research

authors： Carlucci MJ,Scolaro LA,Noseda MD,Cerezo AS,Damonte EB

更新日期：2004-11-01 00:00:00

abstract：:An extract of the cactus plant Opuntia streptacantha inhibited intracellular virus replication and inactivated extracellular virus. Inhibition of virus replication also occurred following pre-infection treatment--a favourable finding in terms of in-vivo limitation of virus disease. There was inhibition of both DNA and...

journal_title：Antiviral research

authors： Ahmad A,Davies J,Randall S,Skinner GR

更新日期：1996-05-01 00:00:00

abstract：:Influenza A virus has been responsible for widespread human epidemics because it is readily transmitted from humans to humans by aerosol. Recent events have highlighted the potential of influenza A virus as a bioterrorist weapon: the high virulence of the influenza A virus that infected people in Hong Kong in 1997; an...

journal_title：Antiviral research

authors： Krug RM

更新日期：2003-01-01 00:00:00

abstract：:The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in m...

journal_title：Antiviral research

authors： Idowu AD,Fraser-Smith EB,Poffenberger KL,Herman RC

更新日期：1992-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zi...

journal_title：Antiviral research

authors： Cancellieri M,Bassetto M,Widjaja I,van Kuppeveld F,de Haan CA,Brancale A

更新日期：2015-10-01 00:00:00

abstract：:Derivation of the 2-aminobenzylstatine containing HIV-1 proteinase (PR) inhibitor I led to a series of compounds with considerably improved antiviral activity, the most potent derivatives inhibiting HIV-1 with IC50 values below 25 nM. This was achieved by the combination of several structural modifications, most promi...

journal_title：Antiviral research

authors： Billich A,Charpiot B,Fricker G,Gstach H,Lehr P,Peichl P,Scholz D,Rosenwirth B

更新日期：1994-12-01 00:00:00

abstract：:Pyrosequencing has been successfully used to monitor resistance in influenza A viruses to the first class of anti-influenza drugs, M2 blockers (adamantanes). In contrast to M2 blockers, resistance to neuraminidase (NA) inhibitors (NAIs) is subtype- and drug-specific. Here, we designed a pyrosequencing assay for detect...

journal_title：Antiviral research

authors： Deyde VM,Okomo-Adhiambo M,Sheu TG,Wallis TR,Fry A,Dharan N,Klimov AI,Gubareva LV

更新日期：2009-01-01 00:00:00

abstract：:We studied the effects of two antiviral agents, human interferon-alpha (IFN-alpha) and ribavirin, on subacute sclerosing panencephalitis (SSPE) virus infections in hamsters. By intracranial administration, IFN-alpha alone improved the survival of infected hamsters by 20% at a dose of 6 x 10(4) IU/kg every other day fo...

journal_title：Antiviral research

authors： Takahashi T,Hosoya M,Kimura K,Ohno K,Mori S,Takahashi K,Shigeta S

更新日期：1998-01-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) has a poor prognosis owing to its intrinsic resistance to chemotherapy. Although zidovudine (AZT) and alpha interferon (IFN-alpha) give rise to some response and improve the prognosis of ATLL, alternative therapies are nee...

journal_title：Antiviral research

authors： Heraud JM,Mortreux F,Merien F,Contamin H,Mahieux R,Pouliquen JF,Wattel E,Gessain A,de Thé H,Bazarbachi A,Hermine O,Kazanji M

更新日期：2006-07-01 00:00:00

abstract：:The prevention and control of disease caused by seasonal and potential pandemic influenza viruses is currently managed by the use influenza vaccines and antivirals. The adamantanes (amantadine and rimantadine) were the first antivirals licensed for use against influenza A viruses and have been used extensively in some...

journal_title：Antiviral research

authors： Barr IG,Hurt AC,Iannello P,Tomasov C,Deed N,Komadina N

更新日期：2007-02-01 00:00:00

abstract：:Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world. Previously, we performed an initial phenotypic screening of 7000 compounds using DENV type 2 (DENV2)-infected BHK-21 cells to identify small molecules which could inhibit virus replicati...

journal_title：Antiviral research

authors： Nobori H,Uemura K,Toba S,Sanaki T,Shishido T,Hall WW,Orba Y,Sawa H,Sato A

更新日期：2020-12-01 00:00:00