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No reduction of HCV viral load in HIV patients co-infected with HCV genotype 1 during a 30 days course of nitazoxanide monotherapy.

Abstract：

:There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infected with HCV genotype 1. Nevertheless no changes in HCV viral load were observed during treatment in none of the patients evaluated. This data suggests that despite the promising results reported for HCV genotype 4 mono-infected patients, NTZ exhibit poor activity as monotherapy in HIV/HCV co-infected patients with genotype 1.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Laufer N,Abusamra L,Bolcic F,Gun A,Rolón MJ,Pérez H,Krolewiecki A,Salomón H,Quarleri J,Cahn P

doi

10.1016/j.antiviral.2011.10.006

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

497-9

issue

3

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(11)00456-6

journal_volume

92

pub_type

杂志文章

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