Abstract:
:delta 12-Prostaglandin J2 (delta 12-PGJ2), a natural dehydration product of prostaglandin D2 present in human body fluids, was shown to suppress Sendai virus replication in monkey kidney cells, at doses non-toxic to uninfected cells. Dramatic inhibition of virus production could be obtained at doses of delta 12-PGJ2 which did not inhibit cellular or viral protein synthesis, suggesting an effect on virus assembly and/or maturation. At the active concentration, delta 12-PGJ2 caused a decrease in glucosamine incorporation into the virus glycoproteins HN and F, and in at least one host cell polypeptide, while it did not affect most cellular glycoproteins and it induced the glycosylation of a 47-kDa cellular polypeptide. These effects were accompanied by the induction of heat shock protein synthesis, which was found to differ in its specificity and kinetics from induction by prostaglandin A1.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Amici C,Palamara AT,Garaci E,Santoro MGdoi
10.1016/0166-3542(92)90072-dsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
129-38issue
2eissn
0166-3542issn
1872-9096pii
0166-3542(92)90072-Djournal_volume
19pub_type
杂志文章abstract::Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the app...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.08.004
更新日期:2011-11-01 00:00:00
abstract::PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phos...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(97)00050-8
更新日期:1997-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104593
更新日期:2019-11-01 00:00:00
abstract::RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2014.01.021
更新日期:2014-04-01 00:00:00
abstract::In an ongoing effort to identify an orally bioavailable compound for the treatment of rhino- and enteroviral infections, a series of vinylacetylene benzimidazoles was recently examined. Previous studies demonstrated the potential for these compounds to possess both good in vitro antiviral activity as well as acceptabl...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(99)00013-3
更新日期:1999-05-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zi...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.08.003
更新日期:2015-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(95)00047-p
更新日期:1995-10-01 00:00:00
abstract::In the scope of the search for new anti-HIV agents interacting with a new target, we developed a high-throughput screening system to detect the interactions between Nef and Hck. Nef is an accessory protein of HIV, which is involved in the pathogenicity of the acquired immunodeficiency syndrome (AIDS). Nef is also a si...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(02)00017-7
更新日期:2002-07-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.10.006
更新日期:2015-12-01 00:00:00
abstract::Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104652
更新日期:2020-01-01 00:00:00
abstract::Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a "shock and kill" strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA ("shock"), treatment with SAHA did not result in a reduction of reservoir size ("kill"). We therefore utilized a com...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.09.002
更新日期:2015-11-01 00:00:00
abstract::Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) was examined for its activity against tomato-spotted wilt virus (TSWV) in tomato plants. Solutions containing 50, 100, 200, 400 and 800 mg/l of the drug were sprayed onto the leaves. The results showed that 100 and 200 mg/l were the most efficient concentration...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(84)90003-2
更新日期:1984-12-01 00:00:00
abstract::Maraviroc, the only CCR5 antagonist HIV inhibitor currently approved, has potent antiviral activity in treatment-experienced individuals infected with CCR5-using HIV-1 (R5 HIV-1). However, recent data from the MOTIVATE trials indicate that R5 HIV-1 can develop resistance to Maraviroc, underscoring the need for additio...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2009.02.199
更新日期:2009-07-01 00:00:00
abstract::Various anthraquinones substituted with hydroxyl, amino, halogen, carboxylic acid, substituted aromatic group, and sulfonate were tested to determine their activity against human immunodeficiency virus type 1 (HIV-1) in primary human lymphocytes. Among the compounds tested, polyphenolic and/or polysulfonate substitute...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(90)90071-e
更新日期:1990-05-01 00:00:00
abstract::Immune evasion by the lethal henipaviruses, Hendra (HeV) and Nipah virus, is mediated by its interferon (IFN) antagonist P gene products, phosphoprotein (P), and the related V and W proteins, which can target the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins to inhibit IFN/STAT signalin...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.09.017
更新日期:2015-12-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infections cause congenital birth defects and disease in immunosuppressed individuals. Antiviral compounds can control infection yet their use is restricted due to concerns of toxicity and the emergence of drug resistant strains. We have evaluated the impact of an RNA Polymerase I (Pol I) ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.02.014
更新日期:2018-05-01 00:00:00
abstract::We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable selectivity against Dengue 2, Yellow fever (Bolivia str...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.03.004
更新日期:2019-07-01 00:00:00
abstract::Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus responsible for a wide range of clinical manifestations. Currently there is no approved antiviral therapy for parvovirus infection. The acyclic nucleoside phosphonate cidofovir (CDV) has been demonstrated to inhi...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.12.003
更新日期:2019-02-01 00:00:00
abstract::The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (GCV) showed concentration-dependent inhibitory properties from 0.05 to 3....
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.06.014
更新日期:2011-09-01 00:00:00
abstract::A fatty acid derivative of ganciclovir (GCV), elaidic acid ganciclovir (E-GCV), has been evaluated for its inhibitory activity against laboratory and clinical strains of herpes simplex type 1 (HSV-1) and type 2 (HSV-2), varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) in human embryonic lung fibroblasts. ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(00)00070-x
更新日期:2000-03-01 00:00:00
abstract::Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic chori...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104558
更新日期:2019-09-01 00:00:00
abstract::Sixteen herpes simplex virus type 1 (HSV-1) and four type 2 (HSV-2) isolates resistant to acyclovir (ACV) were characterized retrospectively for drug resistance. Phenotypic testing was performed by means of tetrazolium reduction assay and genotypic analysis was carried out by sequencing of thymidine kinase (TK) and DN...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.03.002
更新日期:2010-06-01 00:00:00
abstract::Hepatitis C virus (HCV)-specific T cells are key factors in the outcome of acute HCV infection and in protective immunity. This review recapitulates the steps that immunologists have taken in the past 25years to dissect the role of T cell responses in HCV infection. It describes technical as well as disease-specific c...
journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2014.11.009
更新日期:2015-02-01 00:00:00
abstract::Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.03.004
更新日期:2007-09-01 00:00:00
abstract::Conventional treatment of severe viral disease is limited by the narrow choice as well as the often-significant side effects or lack of clear efficacy of antiviral chemotherapy. At the same time, however, it is known that a reduction in viral load leads to significant clinical improvement in a number of important vira...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.05.007
更新日期:2010-08-01 00:00:00
abstract::Interleukin (IL)28-B polymorphism has been related to interferon response in the treatment of hepatitis C, but its role in chronic hepatitis B (CHB) therapy is still poorly understood. We aimed to investigate the effect of IL28-B polymorphisms in the treatment with pegylated-interferon (PEG-IFN) of patients with CHB. ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.11.014
更新日期:2014-02-01 00:00:00
abstract::The 21st International Conference on Antiviral Research provided novel insights and approaches to drug discovery across a wide array of virologic fields. Topics ranged from the chemical synthesis of new compounds against the human immunodeficiency virus (HIV) to the long-term use of established drugs against influenza...
journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2008.09.003
更新日期:2009-01-01 00:00:00
abstract::The first 230 residues of the 298-amino acid glycoprotein G of respiratory syncytial virus (RSV) are sufficient to confer complete resistance to challenge with live RSV, whereas the first 180 residues completely failed (Olmsted et al. (1989) J. Virol. 63, 411-420). The characterization of a protective epitope correspo...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(95)00053-4
更新日期:1995-12-01 00:00:00
abstract::Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.09.001
更新日期:2008-02-01 00:00:00
abstract::For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2005.11.001
更新日期:2006-02-01 00:00:00