当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.

An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.

Abstract：

:Epidermal growth factor receptor (EGFr) has been shown to be induced and activated in cells infected with HPV, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. To investigate this possibility, human foreskin tissue was infected with HPV11 and transplanted onto the renal capsule and the dermis of immunodeficient mice. The animals were treated orally or topically with the potent EGFr inhibitor CP-545130, with treatment starting either immediately following graft attachment, or following a 70 day period to allow development of warts. The rate of appearance of warts, wart size and number were monitored. In addition, we measured intra-lesional HPV replication levels and examined the morphology of the graft tissues. Analysis of the results showed no significant difference between placebo and compound-treated groups, despite high levels of compound present in the graft tissue. We conclude that EGFr kinase activity is not required for the development and maintenance of HPV-11-induced warts in this model.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Parkinson T,Howett MK,Welsh PA,Patrick SD,Neely EB,Flanagan N,Pollack VA,Pustilnik LR,Moyer J,Perros M

doi

10.1016/j.antiviral.2006.12.004

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

43-50

issue

1

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(06)00362-7

journal_volume

74

pub_type

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