Abstract:
:Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC(50) values of 46.85 microg/ml for HBsAg and 65.60 microg/ml for HBeAg at day 9. Consistent with the HBV antigen reduction, PPGC (100 microg/ml) also reduced HBV DNA level by 35.9%. In the duck hepatitis B virus (DHBV) infected ducks, after PPGC was dosed intragastricly (i.g.) once a day for 10 days, the plasma DHBV DNA level was reduced, with an ED(50) value of 47.54 mg/kg. In addition, Southern blot analysis confirmed the in vivo anti-HBV effect of PPGC in ducks and PPGC also reduced the plasma and the liver DHBV DNA level in a dose-dependent manner. Furthermore, significant improvement of the liver was observed after PPGC treatment, as evaluated by the histopathological analysis.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Li J,Huang H,Feng M,Zhou W,Shi X,Zhou Pdoi
10.1016/j.antiviral.2008.03.001subject
Has Abstractpub_date
2008-08-01 00:00:00pages
114-20issue
2eissn
0166-3542issn
1872-9096pii
S0166-3542(08)00244-1journal_volume
79pub_type
杂志文章abstract::A new adamantane derivative N,N'-bis (ethylene)P(1-adamantyl)-phosphonis diamide, was found to inhibit Rous sarcoma virus replication in much the same manner as reported for the parent compound, 1-adamantanamine hydrochloride. ...
journal_title:Antiviral research
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更新日期:1981-11-01 00:00:00
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1997-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2018.01.002
更新日期:2018-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/s0166-3542(01)00175-9
更新日期:2001-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(00)00132-7
更新日期:2001-01-01 00:00:00
abstract::Prunellin, an anti-HIV active compound, was isolated from aqueous extracts of the Chinese medicinal herb, Prunella vulgaris, and purified to chromatographic homogeneity. Infrared and NMR spectroscopy identified prunellin as a polysaccharide. Elemental analyses, precipitation with calcium(II), barium(II), or 9-aminoacr...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(89)90036-3
更新日期:1989-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2008.06.015
更新日期:2008-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2014.10.005
更新日期:2014-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.04.001
更新日期:2011-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2013.01.007
更新日期:2013-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(85)90004-x
更新日期:1985-12-01 00:00:00
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journal_title:Antiviral research
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doi:10.1016/j.antiviral.2005.06.004
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(95)00047-p
更新日期:1995-10-01 00:00:00
abstract::Therapeutic strategies controlling human cytomegalovirus (hCMV) infection are limited due to adverse side effects and emergence of antiviral resistance variants. A compound being evaluated for treating hCMV disease is maribavir (MBV) which disrupts replication by inhibiting the viral kinase pUL97. Previous studies hav...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.09.011
更新日期:2013-11-01 00:00:00
abstract::Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that are widely used for the treatment of hypercholesterolemia. Besides their cholesterol-lowering effect, statins have been reported to have antiviral activity against a variety of viruses, including hepatitis C virus (HCV). Several stat...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2014.02.020
更新日期:2014-05-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2020.104874
更新日期:2020-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.10.014
更新日期:2017-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0166-3542(03)00065-2
更新日期:2003-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104555
更新日期:2019-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2009.09.010
更新日期:2009-12-01 00:00:00
abstract::Due to diverse pathogenic potentials, there is a growing need for anti-HCMV agents. In this study, we show that treatment with DAPT, a γ-secretase inhibitor (GSI), impairs HCMV replication as assessed by a progeny assay based on immunostaining. This effect is not limited to DAPT because other GSIs with different struc...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2020.104867
更新日期:2020-11-01 00:00:00
abstract::Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1). First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, wi...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(99)00036-4
更新日期:1999-09-01 00:00:00