In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L.

Abstract:

:Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC(50) values of 46.85 microg/ml for HBsAg and 65.60 microg/ml for HBeAg at day 9. Consistent with the HBV antigen reduction, PPGC (100 microg/ml) also reduced HBV DNA level by 35.9%. In the duck hepatitis B virus (DHBV) infected ducks, after PPGC was dosed intragastricly (i.g.) once a day for 10 days, the plasma DHBV DNA level was reduced, with an ED(50) value of 47.54 mg/kg. In addition, Southern blot analysis confirmed the in vivo anti-HBV effect of PPGC in ducks and PPGC also reduced the plasma and the liver DHBV DNA level in a dose-dependent manner. Furthermore, significant improvement of the liver was observed after PPGC treatment, as evaluated by the histopathological analysis.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Li J,Huang H,Feng M,Zhou W,Shi X,Zhou P

doi

10.1016/j.antiviral.2008.03.001

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

114-20

issue

2

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(08)00244-1

journal_volume

79

pub_type

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