Dual biological activity of apurinic acid on human lymphocytes: induction of interferon-gamma and protection from human immunodeficiency virus infection in vitro.

abstract：:Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the app...

journal_title：Antiviral research

authors： Hurwitz SJ,Schinazi RF

更新日期：2011-11-01 00:00:00

abstract：:Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because mos...

journal_title：Antiviral research

authors： Chang J,Block TM,Guo JT

更新日期：2013-09-01 00:00:00

abstract：:Antiviral compounds were evaluated for efficacy against yellow fever virus (YFV) in a hamster model of YFV-induced liver disease. Challenge with a 10(2) 50% cell culture infectious doses of YFV resulted in a 50-80% mortality rate in female hamsters. Virus was detected by quantitative real-time RT-PCR (QRT-PCR) in live...

journal_title：Antiviral research

authors： Julander JG,Morrey JD,Blatt LM,Shafer K,Sidwell RW

更新日期：2007-02-01 00:00:00

abstract：:delta 12-Prostaglandin J2 (delta 12-PGJ2), a natural dehydration product of prostaglandin D2 present in human body fluids, was shown to suppress Sendai virus replication in monkey kidney cells, at doses non-toxic to uninfected cells. Dramatic inhibition of virus production could be obtained at doses of delta 12-PGJ2 w...

journal_title：Antiviral research

authors： Amici C,Palamara AT,Garaci E,Santoro MG

更新日期：1992-08-01 00:00:00

abstract：:The latent reservoir of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs ...

journal_title：Antiviral research

authors： Yang H,Li X,Yang X,Lu P,Wang Y,Jiang Z,Pan H,Zhao L,Zhu Y,Khan IU,Shen Y,Lu H,Zhang T,Jiang G,Ma Z,Wu H,Zhu H

更新日期：2019-09-01 00:00:00

abstract：:Human adenoviruses (HAdVs) usually cause mild respiratory infections, but they can also lead to fatal outcomes for immunosuppressive patients. Unfortunately, there has been no specific anti-HAdV drug approved for medical use. A better understanding of the nature of virus-host interactions during infection is beneficia...

journal_title：Antiviral research

authors： Wang X,Zhang Q,Zhou Z,Liu M,Chen Y,Li J,Xu L,Guo J,Li Q,Yang J,Wang S

更新日期：2018-04-01 00:00:00

abstract：:DNA immunizations with the major structural protein VP1 of Coxsackie virus B3 (CVB3) have been previously found to protect BALB/c mice from lethal challenge. Here we report that the other CVB3 capsid proteins, VP2, VP3, and VP4, were less effective at preventing CVB3-caused disease. The application of pCMV/VP1 as a va...

journal_title：Antiviral research

authors： Henke A,Zell R,Stelzner A

更新日期：2001-01-01 00:00:00

abstract：:T Follicular helper cells (TFH) are considered critical for B cell antibody response, and recent efforts have focused on promoting TFH in order to enhance vaccine efficacy. We studied the frequency and function of TFH in nasopharynx-associated lymphoid tissues (NALT) from children and adults, and its role in anti-infl...

journal_title：Antiviral research

authors： Aljurayyan AN,Sharma R,Upile N,Beer H,Vaughan C,Xie C,Achar P,Ahmed MS,McNamara PS,Gordon SB,Zhang Q

更新日期：2016-08-01 00:00:00

abstract：:Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are the two major causative agents of hand, foot and mouth disease (HFMD), for which there are currently no licenced treatments. Here, the acquisition of resistance towards two novel capsid-binding compounds, NLD and ALD, was studied and compared to the analogous co...

journal_title：Antiviral research

authors： Kelly JT,De Colibus L,Elliott L,Fry EE,Stuart DI,Rowlands DJ,Stonehouse NJ

更新日期：2015-12-01 00:00:00

abstract：:The effect of interferon on the replication of herpes simplex virus types 1 and 2 was studied in two murine macrophage-like cell lines which differ in their ability to synthesize interferon. Higher titers of herpes simplex virus type 1 occurred in PU5-1.8 cell cultures where interferon was not produced than in J774A.1...

journal_title：Antiviral research

authors： Salo RJ,Ortega AP

更新日期：1986-05-01 00:00:00

abstract：:Japanese encephalitis virus (JEV) infection is a major cause of acute viral encephalitis both in humans and animals. The domain III of virus envelope protein (EDIII) plays important roles in interacting with host cell receptors to facilitate virus entry. In this study, recombinant JEV EDIII was expressed and purified....

journal_title：Antiviral research

authors： Li C,Zhang LY,Sun MX,Li PP,Huang L,Wei JC,Yao YL,Isahg H,Chen PY,Mao X

更新日期：2012-05-01 00:00:00

abstract：:A new adamantane derivative N,N'-bis (ethylene)P(1-adamantyl)-phosphonis diamide, was found to inhibit Rous sarcoma virus replication in much the same manner as reported for the parent compound, 1-adamantanamine hydrochloride. ...

journal_title：Antiviral research

authors： McGraw TL,Cates LA,Daley LS,Chen YC

更新日期：1981-11-01 00:00:00

abstract：:HSV-1 multiplication rates have been shown to vary in different tissues and the rate of multiplication may correlate with susceptibility to antiviral chemotherapy. Herpetic stromal keratitis is a necrotizing condition refractive to antiviral therapy and this lack of antiviral efficacy in stromal disease may be the res...

journal_title：Antiviral research

authors： Upadhyay JM,Hill JM,Jemison M,Helmy MF,Kaufman HE

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can...

journal_title：Antiviral research

authors： Andreone P,Fiorino S,Cursaro C,Gramenzi A,Margotti M,Di Giammarino L,Biselli M,Miniero R,Gasbarrini G,Bernardi M

更新日期：2001-02-01 00:00:00

abstract：:The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transf...

journal_title：Antiviral research

authors： Yang WT,Yang GL,Wang Q,Huang HB,Jiang YL,Shi CW,Wang JZ,Huang KY,Jin YB,Wang CF

更新日期：2017-02-01 00:00:00

abstract：:In cultured mammalian cells (Vero), different antiviral agents change to differing degrees the ability of HSV2 to down-regulate gap junctions, each agent having a specific effect. Measured by intracellular electrodes, control cell populations showed 49-51% coupling, uninfected populations treated with acyclovir or SDS...

journal_title：Antiviral research

authors： Musée J,Mbuy GN,Woodruff RI

更新日期：2002-11-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:HIV-host infection systems in vitro are important in the pre-clinical assessment of anti-retroviral drug activity. The present report describes the development of a new HIV-host model comprised of an epithelial cell line of HeLa lineage (HeLa-1), transfected with expression vectors bearing tat and rev (TART) genes of ...

journal_title：Antiviral research

authors： Moussazadeh M,Hua J,Sidhu MK,Zhao XX,Fitzgibbon JE,Liao MJ,Rashidbaigi A

更新日期：1999-07-01 00:00:00

abstract：:Although in vitro studies have been performed to dissect the mechanism of action of IFNα, detailed in vivo studies on the long-term effects of IFNα on monocytes have not been performed. Here we examined peripheral blood from 14 chronic HCV patients at baseline and 12 weeks after start of IFNα-based therapy. Monocytes ...

journal_title：Antiviral research

authors： Hou J,Groothuismink ZM,Koning L,Roomer R,van IJcken WF,Kreefft K,Liu BS,Janssen HL,de Knegt RJ,Boonstra A

更新日期：2014-09-01 00:00:00

abstract：:Oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are potent stimulators of the innate immune system, and are capable of aborting several infections in a non-specific manner. We here report studies of the capacity of such ODN to protect mice against infection with foot and mouth disease virus (FMDV). Susc...

journal_title：Antiviral research

authors： Kamstrup S,Frimann TH,Barfoed AM

更新日期：2006-10-01 00:00:00

abstract：:In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A54...

journal_title：Antiviral research

authors： Zhiqiang W,Yaowu Y,Fan Y,Jian Y,Yongfeng H,Lina Z,Jianwei W,Qi J

更新日期：2010-03-01 00:00:00

abstract：:Human metapneumovirus (hMPV) is a recently elucidated respiratory virus pathogen for which there are no agents currently licensed to prevent or treat infections caused by it. However, NMSO3 has been reported to inhibit replication of human respiratory syncytial virus (hRSV), a virus that is closely related to hMPV, bo...

journal_title：Antiviral research

authors： Wyde PR,Moylett EH,Chetty SN,Jewell A,Bowlin TL,Piedra PA

更新日期：2004-07-01 00:00:00

abstract：:Studying the biogenesis of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and developing anti-HBV agents require analytical methods to quantify viral DNA levels inside host cells. The well-accepted Southern blotting method is only semi-quantitative, while the other widely used methods (based on qPCR) ...

journal_title：Antiviral research

authors： Gao Z,Yan L,Li W

更新日期：2019-08-01 00:00:00

abstract：:This mini-review describes the structure-activity relationships of several series of new nucleoside analogues. It also points to the possibilities of finding new molecular modifications which could lead to antivirals with activity both against human immunodeficiency viruses (HIV) and herpesviruses. ...

journal_title：Antiviral research

authors： Herdewijn PA

更新日期：1992-07-01 00:00:00

abstract：:A series of four mannose(Man)-, three N-acetylglucosamine (GlcNAc)n-, ten N-acetylgalactosamine/galactose(GalNAc/Gal)-, one 5-acetylneuraminic acid (alpha-2,3-Gal/GalNAc)- and one 5-acetylneuroaminic acid(alpha-2,6-Gal/Gal-NAc)-specific plant agglutinins were evaluated for their antiviral activity in vitro. the mannos...

journal_title：Antiviral research

authors： Balzarini J,Neyts J,Schols D,Hosoya M,Van Damme E,Peumans W,De Clercq E

更新日期：1992-06-01 00:00:00

abstract：:Maraviroc, the only CCR5 antagonist HIV inhibitor currently approved, has potent antiviral activity in treatment-experienced individuals infected with CCR5-using HIV-1 (R5 HIV-1). However, recent data from the MOTIVATE trials indicate that R5 HIV-1 can develop resistance to Maraviroc, underscoring the need for additio...

journal_title：Antiviral research

authors： Latinovic O,Heredia A,Gallo RC,Reitz M,Le N,Redfield RR

更新日期：2009-07-01 00:00:00

abstract：:RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...

journal_title：Antiviral research

authors： Park IH,Kwon YC,Ryu WS,Ahn BY

更新日期：2014-04-01 00:00:00

abstract：:Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5%. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Avail...

journal_title：Antiviral research

authors： Gan HJ,Harikishore A,Lee J,Jeon S,Rajan S,Chen MW,Neo JL,Kim S,Yoon HS

更新日期：2021-01-01 00:00:00

abstract：:The 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT)-like compounds with homocyclic moieties at the N-1 of the pyrimidinedione, including the highly potent lead compound IQP-0410, inhibit HIV-1 at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism involving allosteric inhibition at...

journal_title：Antiviral research

authors： Buckheit RW Jr,Watson Buckheit K,Sturdevant CB,Buckheit RW 3rd

更新日期：2013-11-01 00:00:00

abstract：:In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB...

journal_title：Antiviral research

authors： Giannecchini S,Wise HM,Digard P,Clausi V,Del Poggetto E,Vesco L,Puzelli S,Donatelli I,Azzi A

更新日期：2011-10-01 00:00:00