Novel nucleoside strategies for anti-HIV and anti-HSV therapy.

abstract：:The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. In this review, we discuss the current state of knowledge of animal models of MERS-CoV infection. Commonly used ...

journal_title：Antiviral research

authors： van Doremalen N,Munster VJ

更新日期：2015-10-01 00:00:00

abstract：:Tiazofurine (2-beta-D-ribofuranosylthiazole-4-carboxamide) was found to inhibit replication of barley stripe mosaic virus (BSMV) in barley and wheat plants. Treatment with this nucleoside analogue delayed and inhibited symptom development and suppressed virus multiplication. The most effective concentration applied tw...

journal_title：Antiviral research

authors： Nagy PD,Gáborjányi R,Kovács L,Farkas I

更新日期：1989-02-01 00:00:00

abstract：:Fifty-nine US isolates of HSV-1 and HSV-2 obtained between 1998 and 2004 were tested for sensitivity to the helicase-primase inhibitor, pritelivir (AIC316, BAY 57-1293) by plaque-reduction assay. All isolates, which were collected prior to any clinical use of primase-helicase inhibitors, were sensitive and showed mean...

journal_title：Antiviral research

authors： Field HJ,Huang ML,Lay EM,Mickleburgh I,Zimmermann H,Birkmann A

更新日期：2013-11-01 00:00:00

abstract：:SeqHepB is a combination of a HBV genome sequence analysis program and a relational database that houses data collected from multiple data sources. Registered users can access the sequence analysis component of SeqHepB online for rapid and detailed interrogation of HBV genomic sequences. Its main function is to determ...

journal_title：Antiviral research

authors： Yuen LK,Ayres A,Littlejohn M,Colledge D,Edgely A,Maskill WJ,Locarnini SA,Bartholomeusz A

更新日期：2007-07-01 00:00:00

abstract：:Development of anti-dengue therapy represents an urgent un-met medical need. Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led to the possibility of structure-based rational design of inhibitors for anti-dengue therapy. These include (i) the structure of the 'active' form of the...

journal_title：Antiviral research

authors： Noble CG,Shi PY

更新日期：2012-11-01 00:00:00

abstract：:Treatment of the chronic hepatitis C virus (HCV) infection is an unmet medical need, and the HCV NS3 serine protease (NS3-SP) has been used as an attractive target of antiviral screening against HCV. To find naturally chemical entities as lead compounds from which novel anti-HCV agents could be developed, bioassay-gui...

journal_title：Antiviral research

authors： Zuo G,Li Z,Chen L,Xu X

更新日期：2007-10-01 00:00:00

abstract：:EV71 is a major causative agent of hand, foot and mouth disease (HFMD) and is responsible for large outbreaks in various Asian Pacific countries. In the present study, we generated the recombinant baculovirus (Bac-VP1) encoding VP1 in a novel expression cassette. The transmembrane domain of hemagglutinin of the H3N2 i...

journal_title：Antiviral research

authors： Premanand B,Kiener TK,Meng T,Tan YR,Jia Q,Chow VT,Kwang J

更新日期：2012-09-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxystilbene) is a natural component of certain foods, such as grapes, that has been shown to have anti-herpes simplex virus (HSV) activity in vitro. To determine if it is active in vivo, the abraded epidermis of SKH1 mice were infected with HSV-1 and topically treated with 12.5 or 25% resver...

journal_title：Antiviral research

authors： Docherty JJ,Smith JS,Fu MM,Stoner T,Booth T

更新日期：2004-01-01 00:00:00

abstract：:Prunellin, an anti-HIV active compound, was isolated from aqueous extracts of the Chinese medicinal herb, Prunella vulgaris, and purified to chromatographic homogeneity. Infrared and NMR spectroscopy identified prunellin as a polysaccharide. Elemental analyses, precipitation with calcium(II), barium(II), or 9-aminoacr...

journal_title：Antiviral research

authors： Tabba HD,Chang RS,Smith KM

更新日期：1989-06-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. In immunocompromised patients, KSHV infection is capable of causing severe and fatal diseases. Current antiviral treatments for KSHV infections consist mostly of n...

journal_title：Antiviral research

authors： Chen J,Zhang H,Chen X

更新日期：2020-08-01 00:00:00

abstract：:Derivatives of beta-lactam antibiotics of the cephalosporin type at 0.02-1 mM concentrations interfered with in vitro replication of two DNA-containing viruses, herpes simplex I and vaccinia, but showed no effects on two RNA-viruses, lymphocytic choriomeningitis virus and vesicular stomatitis virus, or on cell viabili...

journal_title：Antiviral research

authors： Cottagnoud P,Neftel KA,Hany M,Zinkernagel RM

更新日期：1988-11-01 00:00:00

abstract：:High-throughput genomic methods are now being used to study a wide variety of viral diseases, in an effort to understand how host responses to infection can lead either to efficient elimination of the pathogen or the development of severe disease. This article reviews how gene expression studies are addressing importa...

journal_title：Antiviral research

authors： Walters KA,Katze MG

更新日期：2009-03-01 00:00:00

abstract：:The K70E mutation in HIV-1 reverse transcriptase was observed in 10% of virologic non-responders of the abacavir/lamivudine/tenofovir arm of ESS30009, alone, or in mixtures with K65R by population sequencing. Clonal analysis of six ESS30009 K70E isolates failed to identify double mutants carrying K65R+K70E. Site-direc...

journal_title：Antiviral research

authors： Kagan RM,Lee TS,Ross L,Lloyd RM Jr,Lewinski MA,Potts SJ

更新日期：2007-09-01 00:00:00

abstract：:Knowledge of drug protein-binding and blood cell partitioning may be important for evaluating the pharmacokinetic parameters of zidovudine, particularly because of its intracellular site of action and potential to induce side effects. Equilibrium dialysis studies of zidovudine were performed over 2 h to identify the e...

journal_title：Antiviral research

authors： Luzier A,Morse GD

更新日期：1993-07-01 00:00:00

abstract：:Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC eff...

journal_title：Antiviral research

authors： Li J,Huang H,Feng M,Zhou W,Shi X,Zhou P

更新日期：2008-08-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFr) has been shown to be induced and activated in cells infected with HPV, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. To investigate this possibility, human foreskin tissue was infected with HPV11 and transplant...

journal_title：Antiviral research

authors： Parkinson T,Howett MK,Welsh PA,Patrick SD,Neely EB,Flanagan N,Pollack VA,Pustilnik LR,Moyer J,Perros M

更新日期：2007-04-01 00:00:00

abstract：:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2...

journal_title：Antiviral research

authors： Verheyden B,Andries K,Rombaut B

更新日期：2004-03-01 00:00:00

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guilla...

journal_title：Antiviral research

authors： Albulescu IC,Kovacikova K,Tas A,Snijder EJ,van Hemert MJ

更新日期：2017-07-01 00:00:00

abstract：:A series of four mannose(Man)-, three N-acetylglucosamine (GlcNAc)n-, ten N-acetylgalactosamine/galactose(GalNAc/Gal)-, one 5-acetylneuraminic acid (alpha-2,3-Gal/GalNAc)- and one 5-acetylneuroaminic acid(alpha-2,6-Gal/Gal-NAc)-specific plant agglutinins were evaluated for their antiviral activity in vitro. the mannos...

journal_title：Antiviral research

authors： Balzarini J,Neyts J,Schols D,Hosoya M,Van Damme E,Peumans W,De Clercq E

更新日期：1992-06-01 00:00:00

abstract：:Prostaglandins are potentially useful antiviral agents, however their mechanism of action is unclear. Recent evidence suggests that RNA transcription of vesicular stomatitis virus (VSV) is inhibited by prostaglandins (Bader and Ankel, J. Gen. Virol. 71, 2823-2832, 1990). Prostaglandins are known to have multiple effec...

journal_title：Antiviral research

authors： Parker J,Ahrens PB,Ankel H

更新日期：1995-01-01 00:00:00

abstract：:The global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012-13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the...

journal_title：Antiviral research

authors： Takashita E,Daniels RS,Fujisaki S,Gregory V,Gubareva LV,Huang W,Hurt AC,Lackenby A,Nguyen HT,Pereyaslov D,Roe M,Samaan M,Subbarao K,Tse H,Wang D,Yen HL,Zhang W,Meijer A

更新日期：2020-03-01 00:00:00

abstract：:Several pyrophosphate analogues have been studied for their effects on avian myeloblastosis virus reverse transcriptase and on cellular DNA polymerase alpha. Examination of structure-activity relationships for these compounds revealed that two acidic groups connected by a short bridge were necessary, but not sufficien...

journal_title：Antiviral research

authors： Eriksson B,Stening G,Oberg B

更新日期：1982-05-01 00:00:00

abstract：:A newly synthesized imide derivative of 3-nitro-1,8-naphthalic acid, 5-amino-2-(2-dimethylaminoethyl)benzo-[de]-isoquinolin-1,3-dione (designated M-FA-142), was tested on chick embryo cells against herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), and on Vero cells against African swine fever virus (ASFV). ...

journal_title：Antiviral research

authors： García Gancedo A,Gil-Fernández C,Vilas P,Pérez S,Rodriguez F,Paez E,Braña MF,Roldán CM

更新日期：1984-08-01 00:00:00

abstract：:The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptom...

journal_title：Antiviral research

authors： Bavagnoli L,Campanini G,Forte M,Ceccotti G,Percivalle E,Bione S,Lisa A,Baldanti F,Maga G

更新日期：2019-11-01 00:00:00

abstract：:Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression i...

journal_title：Antiviral research

authors： Gulakowski RJ,McMahon JB,Buckheit RW Jr,Gustafson KR,Boyd MR

更新日期：1997-01-01 00:00:00

abstract：:Avian influenza A(H6N1) virus is one of the most common viruses isolated from migrating birds and domestic poultry in many countries. The first and only known case of human infection by H6N1 virus in the world was reported in Taiwan in 2013. This led to concern that H6N1 virus may cause a threat to public health. In t...

journal_title：Antiviral research

authors： Yang JR,Chen CY,Kuo CY,Cheng CY,Lee MS,Cheng MC,Yang YC,Wu CY,Wu HS,Liu MT,Hsiao PW

更新日期：2016-02-01 00:00:00

abstract：:A synthetic muramyldipeptide (MDP) and two analogues, B30-MDP and MDP-Lys(L18), augmented serum interferon (IFN) production in mice by the inducers lipopolysaccharide (LPS) and polyinosinic acid:polycytidylic acid (poly I:C), and also augmented immune IFN production induced by purified protein derivative (PPD) in myco...

journal_title：Antiviral research

authors： Ikeda S,Matsuda Y,Nishimura C

更新日期：1985-12-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. We have reported (Cubillos et al., 2008) that a synthetic dendrimeric peptide consisting of four copies of a B-cell epitope [VP1(136-154)] linked through thioether bonds to a T-cell epitope [3A(21-35)] of FMDV [B4T(thi)] e...

journal_title：Antiviral research

authors： Blanco E,Guerra B,de la Torre BG,Defaus S,Dekker A,Andreu D,Sobrino F

更新日期：2016-05-01 00:00:00

abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

journal_title：Antiviral research

authors： Kariya M,Mori S,Eizuru Y

更新日期：2000-02-01 00:00:00

abstract：:Favipiravir (T-705) is a broad spectrum antiviral which has been approved in Japan for the treatment of severe influenza virus infections. We reported earlier that favipiravir inhibits the in vitro replication of CHIKV and protects against disease progression in CHIKV-infected immunodeficient mice. We here explored wh...

journal_title：Antiviral research

authors： Abdelnabi R,Jochmans D,Verbeken E,Neyts J,Delang L

更新日期：2018-01-01 00:00:00