Abstract:
:HIV-infected patients are at increased risk of decreased bone mineral density. Several studies have implicated antiretroviral therapy as a contributor to the decreased bone mineral density seen in treated HIV-1 patients. Whilst the exact molecular mechanisms underlying decreased bone density remain to be elucidated, inflammation has been postulated to be an important pathogenomic mechanism. In this study, we have explored primary human osteoblast gene expression in response to protease inhibitors (PIs), by oligonucleotide microarray analysis. A list of dysregulated genes, correlated with the inflammatory response, increased significantly after NFV and RTV exposure. Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV. These data suggested that generation of local inflammatory cascades may contribute to the development of decreased bone mineral density in highly active antiretroviral therapy (HAART)-treated HIV patients.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Malizia AP,Vioreanu MH,Doran PP,Powderly WGdoi
10.1016/j.antiviral.2006.12.003subject
Has Abstractpub_date
2007-04-01 00:00:00pages
72-6issue
1eissn
0166-3542issn
1872-9096pii
S0166-3542(06)00359-7journal_volume
74pub_type
杂志文章abstract::In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A54...
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更新日期:1998-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.01.003
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0166-3542(90)90005-r
更新日期:1990-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/0166-3542(96)06966-5
更新日期:1996-07-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2015.06.019
更新日期:2015-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(89)90019-3
更新日期:1989-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.03.011
更新日期:2012-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(86)90010-0
更新日期:1986-05-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2009.07.005
更新日期:2009-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.antiviral.2009.11.004
更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.01.022
更新日期:2017-05-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.08.004
更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2009.02.199
更新日期:2009-07-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104650
更新日期:2020-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.10.006
更新日期:2011-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/s0166-3542(03)00008-1
更新日期:2003-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104648
更新日期:2020-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2020.104996
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Cases of sustained-virological response (SVR or cure) after an ultra-short duration (≤27 days) of direct-acting antiviral (DAA)-based therapy, despite HCV being detected at end of treatment (EOT), have been reported. Established HCV mathematical models that predict the treatment duration required to achieve ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.06.019
更新日期:2017-08-01 00:00:00
abstract::Transcriptional activation of HIV-1 gene expression is partially controlled by the interaction between viral and cellular transcription factors acting at HIV-1 long terminal repeat (LTR) sequences. HIV-1 subtyping at LTR region and nucleotide LTR variability from clinical samples in 48 subjects carrying different HIV-...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.08.007
更新日期:2010-11-01 00:00:00
abstract::Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(01)00150-4
更新日期:2001-09-01 00:00:00