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A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza.

Abstract：

:The role of humoral response in the effective control of infection by influenza viruses is well known, but the protection is usually limited to the infecting or vaccinating isolate and to few related strains. Recent studies have evidenced the existence of B-cell epitopes broadly conserved among different influenza subtypes recognized by monoclonal antibodies endowed with unprecedented broad activity. In this review, all major monoclonal antibodies directed against different influenza virus proteins are reported and their potential in the design of new anti-influenza prophylactic or therapeutic strategies is discussed.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Mancini N,Solforosi L,Clementi N,De Marco D,Clementi M,Burioni R

doi

10.1016/j.antiviral.2011.07.013

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

15-26

issue

1

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(11)00384-6

journal_volume

92

pub_type

杂志文章,评审

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