Abstract:
:More than 50% of a group of healthy homosexuals in Israel were found to have an activated interferon (IFN) system as evidenced by markedly elevated blood IFN levels, increased in vitro production of IFN by unstimulated peripheral blood mononuclear cells and HuIFN-alpha and HuIFN-gamma production by appropriately stimulated cells, and a surprisingly high incidence of an antiviral state of cells. This pattern resembles that found in persons with acute viral illness, and is unlike that found in normal healthy controls. The type of IFN in the blood was found to be unusual in that it was mainly HuIFN-alpha, pH 2-labile, a type of IFN found in certain collagen diseases as well as in homosexual men suffering from Kaposi's sarcoma or lymphadenopathy. Natural killer (NK) cytotoxic activity was found to be somewhat lower than that found in normal controls, although no correlation was found between blood IFN levels and NK activity. Mean (2'-5')-oligoisoadenylate synthetase levels in cell extracts were intermediate between normal controls and patients with viral illness. Likewise no correlation was found between enzyme levels and blood IFN levels. The highly activated IFN system found in certain homosexuals, as well as the increased spontaneous production of IFN by unstimulated mononuclear cells, suggest the possibility of the presence of a virus, active or latent, in these individuals. This virus could be a retrovirus such as HTLV-III or LAV which have recently been isolated from AIDS patients. The special type of IFN present could be the response to a novel virus in an unusual situation. On the basis of recent reports, we speculate that homosexuals with highly activated IFN systems who produce pH 2-labile HuIFN-alpha could be at increased risk for developing AIDS.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Levin S,Hahn T,Handzel ZT,Galili-Wiesstub E,Bregman V,Myer R,Tinowitz M,Altman Y,Barzilai N,Brenner Ydoi
10.1016/0166-3542(85)90027-0subject
Has Abstract,Author List Incompletepub_date
1985-08-01 00:00:00pages
229-40issue
4eissn
0166-3542issn
1872-9096pii
0166-3542(85)90027-0journal_volume
5pub_type
杂志文章abstract::Genital herpes, caused by either herpes simplex virus type 1 or 2 (HSV-1 and HSV-2), is a significant public health problem worldwide. It increases the risk of infection with HIV, upregulates HIV after infection and can be associated with serious morbidity and mortality. It is now known that clinical and subclinical v...
journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2004.06.002
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journal_title:Antiviral research
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doi:10.1016/j.antiviral.2005.06.004
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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abstract::Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...
journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2006.04.004
更新日期:2006-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.antiviral.2015.12.003
更新日期:2016-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.08.024
更新日期:2013-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.12.001
更新日期:2017-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.05.009
更新日期:2017-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2014.10.005
更新日期:2014-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2020.104905
更新日期:2020-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(87)90085-4
更新日期:1987-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(95)00989-2
更新日期:1996-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.02.001
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0166-3542(99)00074-1
更新日期:2000-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.12.018
更新日期:2018-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(99)00013-3
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journal_title:Antiviral research
pub_type:
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.09.005
更新日期:2018-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.antiviral.2005.04.001
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0166-3542(93)90091-v
更新日期:1993-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.06.013
更新日期:2011-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2017.11.001
更新日期:2018-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.06.005
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:We sought to investigate the differences in monocyte immune responses to the dengue virus (DENV) in those who previously had either severe disease (past SD) or non-severe dengue (past NSD) following a secondary dengue infection. METHOD:Monocytes from healthy individuals who had either past SD (n = 6) or past...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104554
更新日期:2019-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(02)00006-2
更新日期:2002-07-01 00:00:00
abstract::Natural compounds provide a large reservoir of potentially active anti-hepatitis B virus (HBV) agents. We examined the direct effects of protocatechuic aldehyde (PA; derived from the Chinese herb, Salvia miltiorrhiza) on HBV replication in HepG2 2.2.15 cell line and duck hepatitis B virus (DHBV) replication in ducklin...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2006.12.005
更新日期:2007-04-01 00:00:00