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Protocatechuic aldehyde inhibits hepatitis B virus replication both in vitro and in vivo.

Abstract：

:Natural compounds provide a large reservoir of potentially active anti-hepatitis B virus (HBV) agents. We examined the direct effects of protocatechuic aldehyde (PA; derived from the Chinese herb, Salvia miltiorrhiza) on HBV replication in HepG2 2.2.15 cell line and duck hepatitis B virus (DHBV) replication in ducklings in vivo. The extracellular HBV DNA, hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) concentrations in cell culture medium were determined by quantitative real-time PCR and ELISA, respectively. DHBV in duck serum was analyzed by dot blot. PA appeared to downregulate the secretion of HBsAg and HBeAg as well as the release of HBV DNA from HepG2 2.2.15 in a dose- and time-dependent manner at concentrations between 24 and 48 microg/mL. PA (25, 50, or 100 mg/kg, intraperitoneally, twice daily) also reduced viremia in DHBV-infected ducks. We provide the first evidence that PA, a novel anti-HBV substance derived from traditional Chinese herb S. miltiorrhiza, can efficiently inhibits HBV replication in HepG2 2.2.15 cell line in vitro and inhibit DHBV replication in ducks in vivo. PA therefore warrants further investigation as a potential therapeutic agent for HBV infections.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Zhou Z,Zhang Y,Ding XR,Chen SH,Yang J,Wang XJ,Jia GL,Chen HS,Bo XC,Wang SQ

doi

10.1016/j.antiviral.2006.12.005

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

59-64

issue

1

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(06)00360-3

journal_volume

74

pub_type

杂志文章

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