Abstract:
:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compounds showed marked antiviral efficacy. The inactivity of the TSAO-T derivatives may most likely be explained by either their different 4'-configuration or their different chemical structure that may not allow an optimal interaction of the molecules with the lipophilic binding pocket of the HIV-1 reverse transcriptase.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Ingate S,De Clercq E,Balzarini J,Camarasa MJdoi
10.1016/s0166-3542(95)00989-2subject
Has Abstractpub_date
1996-11-01 00:00:00pages
149-64issue
3eissn
0166-3542issn
1872-9096pii
S0166354295009892journal_volume
32pub_type
杂志文章abstract::Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mort...
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.01.005
更新日期:2011-03-01 00:00:00