当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.

Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.

Abstract：

:Fifty-nine US isolates of HSV-1 and HSV-2 obtained between 1998 and 2004 were tested for sensitivity to the helicase-primase inhibitor, pritelivir (AIC316, BAY 57-1293) by plaque-reduction assay. All isolates, which were collected prior to any clinical use of primase-helicase inhibitors, were sensitive and showed mean EC50 values of 0.026 and 0.029μM for HSV-1 and HSV-2, respectively. Furthermore, several laboratory-selected acyclovir-resistant HSV mutants were also sensitive to pritelivir. These data provide a baseline for HSV sensitivity to pritelivir in general population before it is introduced and broadly used to treat HSV infection. The data also validate pritelivir as an appropriate therapy for nucleoside-resistant HSV infections.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Field HJ,Huang ML,Lay EM,Mickleburgh I,Zimmermann H,Birkmann A

doi

10.1016/j.antiviral.2013.08.024

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

297-9

issue

2

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(13)00244-1

journal_volume

100

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding.

    abstract：:Cathelicidin antimicrobial peptides (human LL-37 and mouse CRAMP) are mainly virucidal to enveloped virus. However, the effects and relative mechanisms of LL-37 and CRAMP on non-enveloped virus are elusive. We herein found that CRAMP expression was significantly up-regulated post non-enveloped Enterovirus 71 (EV71) in...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2021.105021

    authors： Yu J,Dai Y,Fu Y,Wang K,Yang Y,Li M,Xu W,Wei L

    更新日期：2021-01-25 00:00:00

  • Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410.

    abstract：:The 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT)-like compounds with homocyclic moieties at the N-1 of the pyrimidinedione, including the highly potent lead compound IQP-0410, inhibit HIV-1 at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism involving allosteric inhibition at...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.09.005

    authors： Buckheit RW Jr,Watson Buckheit K,Sturdevant CB,Buckheit RW 3rd

    更新日期：2013-11-01 00:00:00

  • A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA.

    abstract：:T Follicular helper cells (TFH) are considered critical for B cell antibody response, and recent efforts have focused on promoting TFH in order to enhance vaccine efficacy. We studied the frequency and function of TFH in nasopharynx-associated lymphoid tissues (NALT) from children and adults, and its role in anti-infl...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.05.021

    authors： Aljurayyan AN,Sharma R,Upile N,Beer H,Vaughan C,Xie C,Achar P,Ahmed MS,McNamara PS,Gordon SB,Zhang Q

    更新日期：2016-08-01 00:00:00

  • Altered monocyte response to the dengue virus in those with varying severity of past dengue infection.

    abstract：OBJECTIVE:We sought to investigate the differences in monocyte immune responses to the dengue virus (DENV) in those who previously had either severe disease (past SD) or non-severe dengue (past NSD) following a secondary dengue infection. METHOD:Monocytes from healthy individuals who had either past SD (n = 6) or past...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104554

    authors： Kamaladasa A,Gomes L,Wijesinghe A,Jeewandara C,Toh YX,Jayathilaka D,Ogg GS,Fink K,Malavige GN

    更新日期：2019-09-01 00:00:00

  • 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.

    abstract：:The dengue fever virus (DENV) and the yellow fever virus (YFV) are members of the genus flavivirus in the family Flaviviridae. An estimated 50-100 million cases of DENV infections occur each year and approximately half a million patients require hospitalization. There is no vaccine or effective antiviral treatment ava...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.01.011

    authors： De Burghgraeve T,Selisko B,Kaptein S,Chatelain G,Leyssen P,Debing Y,Jacobs M,Van Aerschot A,Canard B,Neyts J

    更新日期：2013-05-01 00:00:00

  • Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease.

    abstract：:Treatment of the chronic hepatitis C virus (HCV) infection is an unmet medical need, and the HCV NS3 serine protease (NS3-SP) has been used as an attractive target of antiviral screening against HCV. To find naturally chemical entities as lead compounds from which novel anti-HCV agents could be developed, bioassay-gui...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2007.06.001

    authors： Zuo G,Li Z,Chen L,Xu X

    更新日期：2007-10-01 00:00:00

  • Identification of KX2-391 as an inhibitor of HBV transcription by a recombinant HBV-based screening assay.

    abstract：:Antiviral therapies for chronic hepatitis B virus (HBV) infection that are currently applicable for clinical use are limited to nucleos(t)ide analogs targeting HBV polymerase activity and pegylated interferon alpha (PEG-IFN). Towards establishing an effective therapy for HBV related diseases, it is important to develo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.06.005

    authors： Harada K,Nishitsuji H,Ujino S,Shimotohno K

    更新日期：2017-08-01 00:00:00

  • Highlights of the 30th International Conference on Antiviral Research.

    abstract：:The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of...

    journal_title：Antiviral research

    pub_type：

    doi：10.1016/j.antiviral.2017.07.017

    authors： Andrei G,Carter K,Janeba Z,Sampath A,Schang LM,Tarbet EB,Vere Hodge RA,Bray M,Esté JA

    更新日期：2017-09-01 00:00:00

  • Functional analysis of influenza RNA polymerase activity by the use of caps, oligonucleotides and polynucleotides.

    abstract：:The effects of caps, dinucleotides, oligonucleotides and polynucleotides on influenza virus RNA polymerase activity have been investigated. The results show that both methyl groups in a cap are necessary for optimal stimulation of polymerase activity. Both m7G(5')ppp(5')Am and ApG stimulated the influenza RNA polymera...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(81)90036-x

    authors： Stridh S,Oberg B,Chattopadhyaya J,Josephson S

    更新日期：1981-06-01 00:00:00

  • Mode of action of 2-furylmercury chloride, an anti-rhinovirus compound.

    abstract：:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2003.10.004

    authors： Verheyden B,Andries K,Rombaut B

    更新日期：2004-03-01 00:00:00

  • Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery.

    abstract：:Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.03.011

    authors： Kneidinger D,Ibrišimović M,Lion T,Klein R

    更新日期：2012-06-01 00:00:00

  • A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck.

    abstract：:In the scope of the search for new anti-HIV agents interacting with a new target, we developed a high-throughput screening system to detect the interactions between Nef and Hck. Nef is an accessory protein of HIV, which is involved in the pathogenicity of the acquired immunodeficiency syndrome (AIDS). Nef is also a si...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(02)00017-7

    authors： Murakami Y,Fukazawa H,Kobatake T,Yamagoe S,Takebe Y,Tobiume M,Matsuda M,Uehara Y

    更新日期：2002-07-01 00:00:00

  • Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

    abstract：:Infection by one of the 4 distinct serotypes of dengue virus (DENV) threatens >40% of the world's population, with no efficacious vaccine or antiviral agent currently available. DENV replication through the virus-encoded nonstructural protein (NS) 5 protein occurs in the infected cell cytoplasm, but NS5 from DENV2 has...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.06.002

    authors： Tay MY,Fraser JE,Chan WK,Moreland NJ,Rathore AP,Wang C,Vasudevan SG,Jans DA

    更新日期：2013-09-01 00:00:00

  • Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation.

    abstract：:delta 12-Prostaglandin J2 (delta 12-PGJ2), a natural dehydration product of prostaglandin D2 present in human body fluids, was shown to suppress Sendai virus replication in monkey kidney cells, at doses non-toxic to uninfected cells. Dramatic inhibition of virus production could be obtained at doses of delta 12-PGJ2 w...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(92)90072-d

    authors： Amici C,Palamara AT,Garaci E,Santoro MG

    更新日期：1992-08-01 00:00:00

  • Hepatitis C virus NS3/4A protease.

    abstract：:Despite an urgent medical need, a broadly effective anti-viral therapy for the treatment of infections with hepatitis C viruses (HCVs) has yet to be developed. One of the approaches to anti-HCV drug discovery is the design and development of specific small molecule drugs to inhibit the proteolytic processing of the HC...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：

    authors： Kwong AD,Kim JL,Rao G,Lipovsek D,Raybuck SA

    更新日期：1999-02-01 00:00:00

  • Reverse genetics approaches to combat pathogenic arenaviruses.

    abstract：:Several arenaviruses cause hemorrhagic fever (HF) in humans, and evidence indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance. Moreover, arenaviruses pose a biodefense threat. No licensed anti-arenavirus vaccine...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2008.08.002

    authors： de la Torre JC

    更新日期：2008-12-01 00:00:00

  • The role of adjuvant immunomodulatory agents for treatment of severe influenza.

    abstract：:A severe inflammatory immune response with hypercytokinemia occurs in patients hospitalized with severe influenza, such as avian influenza A(H5N1), A(H7N9), and seasonal A(H1N1)pdm09 virus infections. The role of immunomodulatory therapy is unclear as there have been limited published data based on randomized controll...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2018.01.002

    authors： Hui DS,Lee N,Chan PK,Beigel JH

    更新日期：2018-02-01 00:00:00

  • Protein kinases C as potential host targets for the inhibition of chikungunya virus replication.

    abstract：:We have shown previously that prostratin, a non-tumor promoting phorbol ester, inhibits chikungunya virus (CHIKV)-induced cytopathic effects in vitro. Prostratin is a potent activator of protein kinases C (PKC), a family of related serine/threonine kinases that regulate many cellular processes such as proliferation an...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.12.020

    authors： Abdelnabi R,Amrun SN,Ng LF,Leyssen P,Neyts J,Delang L

    更新日期：2017-03-01 00:00:00

  • A novel RSV F-Fc fusion protein vaccine reduces lung injury induced by respiratory syncytial virus infection.

    abstract：:Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory tract of young children, and there is currently no licensed vaccine to prevent RSV infection. The F glycoprotein is considered a major antigenic target for RSV vaccine development. Recent evidence indicates that the pre-fus...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.02.017

    authors： Zhang Y,Zhou Z,Zhu SL,Zu X,Wang Z,Zhang LK,Wang W,Xiao G

    更新日期：2019-05-01 00:00:00

  • Immunological and biochemical characterizations of coxsackievirus A6 and A10 viral particles.

    abstract：:Childhood exanthema caused by different serotypes of coxsackievirus (CV-A) and enterovirus A71 (EV-A71) has become a serious global health problem; it is commonly known as hand, foot, and mouth disease (HFMD). Current EV-A71 vaccine clinical trials have demonstrated that human antibody responses generated by EV-A71 va...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.02.008

    authors： Liu CC,Guo MS,Wu SR,Lin HY,Yang YT,Liu WC,Chow YH,Shieh DB,Wang JR,Chong P

    更新日期：2016-05-01 00:00:00

  • Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates.

    abstract：:Currently used antiretroviral therapy is highly successful but there is still a need for new effective and safe prophylactics and therapeutics. We have previously identified and characterized a human engineered antibody domain (eAd), m36, which exhibits potent broadly neutralizing activity against HIV-1 by targeting a...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.08.004

    authors： Chen W,Xiao X,Wang Y,Zhu Z,Dimitrov DS

    更新日期：2010-10-01 00:00:00

  • Preferential selection of heterologous G3-VP7 gene in the genetic background of simian rotavirus SA11 detected by using a homotypic single-VP7 gene-substitution reassortant.

    abstract：:Introduction of segmented genomes into virion is an important process in viral replication of rotavirus. We previously studied the assortment of the VP7 gene segment (encoding outer capsid protein VP7) in the genetic background of simian rotavirus SA11 (G serotype 3, G3) and found the preferential selection of homolog...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(98)00006-0

    authors： Okada J,Kobayashi N,Taniguchi K,Urasawa S

    更新日期：1998-04-01 00:00:00

  • Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice.

    abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(94)90038-8

    authors： Ovcharenko AV,Zhirnov OP

    更新日期：1994-02-01 00:00:00

  • The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.

    abstract：:The bicyclams represent a new class of highly potent and selective HIV inhibitors. Time-of-addition experiments have previously shown that these compounds interfere with an early event in the viral replicative cycle. Additional experiments have now been carried out in order to investigate in more detail the mechanism ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(95)00837-3

    authors： De Vreese K,Reymen D,Griffin P,Steinkasserer A,Werner G,Bridger GJ,Esté J,James W,Henson GW,Desmyter J,Anné J,De Clercq I

    更新日期：1996-03-01 00:00:00

  • Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses.

    abstract：:Flaviviruses constitute a public health concern because of their global burden and the lack of specific antiviral treatment. Here we investigated the antiviral activity of the alkaloid anisomycin against dengue (DENV) and Zika (ZIKV) viruses. At non-cytotoxic concentrations, anisomycin strongly inhibited the replicati...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104749

    authors： Quintana VM,Selisko B,Brunetti JE,Eydoux C,Guillemot JC,Canard B,Damonte EB,Julander JG,Castilla V

    更新日期：2020-04-01 00:00:00

  • Drastic decrease of transcription activity due to hypermutated long terminal repeat (LTR) region in different HIV-1 subtypes and recombinants.

    abstract：:Transcriptional activation of HIV-1 gene expression is partially controlled by the interaction between viral and cellular transcription factors acting at HIV-1 long terminal repeat (LTR) sequences. HIV-1 subtyping at LTR region and nucleotide LTR variability from clinical samples in 48 subjects carrying different HIV-...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.08.007

    authors： de Arellano ER,Alcamí J,López M,Soriano V,Holguín A

    更新日期：2010-11-01 00:00:00

  • Antiviral activity against Middle East Respiratory Syndrome coronavirus by Montelukast, an anti-asthma drug.

    abstract：:Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5%. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Avail...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104996

    authors： Gan HJ,Harikishore A,Lee J,Jeon S,Rajan S,Chen MW,Neo JL,Kim S,Yoon HS

    更新日期：2021-01-01 00:00:00

  • Crimean-Congo hemorrhagic fever in Turkey: Current status and future challenges.

    abstract：:Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mort...

    journal_title：Antiviral research

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.antiviral.2015.12.003

    authors： Leblebicioglu H,Ozaras R,Irmak H,Sencan I

    更新日期：2016-02-01 00:00:00

  • Inhibition of HIV entry by carbohydrate-binding proteins.

    abstract：:Carbohydrate-binding proteins (CBP) can be isolated from a variety of species, including procaryotes (i.e. cyanobacteria), sea corals, algae, plants, invertebrates and vertebrates. A number of them, in particular those CBP that show specific recognition for mannose (Man) and N-acetylglucosamine (GlcNAc) are endowed wi...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2006.02.004

    authors： Balzarini J

    更新日期：2006-09-01 00:00:00

  • Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation.

    abstract：:Infection with the oncogenic γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) cause several severe malignancies in humans. Inhibition of the lytic replication of EBV and KSHV eliminates the reservoir of persistent infection and transmission, consequently preventing the occurr...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.12.002

    authors： Huang L,Yang M,Yuan Y,Li X,Kuang E

    更新日期：2017-02-01 00:00:00