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Mode of action of 2-furylmercury chloride, an anti-rhinovirus compound.

Abstract：

:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2 (antiviral group B, minor receptor group), and compared with an antiviral compound for which the viral target was already determined (enviroxime). 2-FMC was found to bind reversibly to virus particles. However, time-dependent plaque reduction assays revealed that 2-FMC did not interfere with early events of HRV-2 replication. Using a quantitative RT-PCR ELISA assay, we were able to prove that 2-FMC inhibits the synthesis of viral RNA. However, the mode of action of 2-FMC is not identical to that of enviroxime, another inhibitor of viral RNA synthesis. Time-of-addition and time-of-withdrawal experiments demonstrated that 2-FMC acted during a broader time interval than enviroxime.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Verheyden B,Andries K,Rombaut B

doi

10.1016/j.antiviral.2003.10.004

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

189-94

issue

3

eissn

0166-3542

issn

1872-9096

pii

S0166354203002407

journal_volume

61

pub_type

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