Dead-end complexes contribute to the synergistic inhibition of HIV-1 RT by the combination of rilpivirine, emtricitabine, and tenofovir.

abstract：:Influenza viruses (IV) continue to pose an imminent threat to human welfare. Yearly re-occurring seasonal epidemic outbreaks and pandemics with high mortality can occur. Besides vaccination against a limited number of viral strains only a few antiviral drugs are available, which are losing their effectiveness as more ...

journal_title：Antiviral research

authors： Haasbach E,Müller C,Ehrhardt C,Schreiber A,Pleschka S,Ludwig S,Planz O

更新日期：2017-06-01 00:00:00

abstract：:Although in vitro studies have been performed to dissect the mechanism of action of IFNα, detailed in vivo studies on the long-term effects of IFNα on monocytes have not been performed. Here we examined peripheral blood from 14 chronic HCV patients at baseline and 12 weeks after start of IFNα-based therapy. Monocytes ...

journal_title：Antiviral research

authors： Hou J,Groothuismink ZM,Koning L,Roomer R,van IJcken WF,Kreefft K,Liu BS,Janssen HL,de Knegt RJ,Boonstra A

更新日期：2014-09-01 00:00:00

abstract：:Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are the two major causative agents of hand, foot and mouth disease (HFMD), for which there are currently no licenced treatments. Here, the acquisition of resistance towards two novel capsid-binding compounds, NLD and ALD, was studied and compared to the analogous co...

journal_title：Antiviral research

authors： Kelly JT,De Colibus L,Elliott L,Fry EE,Stuart DI,Rowlands DJ,Stonehouse NJ

更新日期：2015-12-01 00:00:00

abstract：:We studied susceptibility to herpes labialis by exposing 20 volunteers to experimental ultraviolet radiation (UVR) on three occasions at 3- to 4-month intervals. The number of patients who developed lesions after each session was 9/20 (45%), 9/20 (45%) and 14/20 (70%). Herpes simplex virus (HSV) was isolated from 21/2...

journal_title：Antiviral research

authors： Spruance SL,Kriesel JD,Evans TG,McKeough MB

更新日期：1995-09-01 00:00:00

abstract：:Almost all cases of human rabies result from dog bites, making the elimination of canine rabies a global priority. During recent decades, many countries in the Western Hemisphere have carried out large-scale dog vaccination campaigns, controlled their free-ranging dog populations and enforced legislation for responsib...

journal_title：Antiviral research

authors： Velasco-Villa A,Escobar LE,Sanchez A,Shi M,Streicker DG,Gallardo-Romero NF,Vargas-Pino F,Gutierrez-Cedillo V,Damon I,Emerson G

更新日期：2017-07-01 00:00:00

abstract：:The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...

journal_title：Antiviral research

authors： Alotte C,Martin A,Caldarelli SA,Di Giorgio A,Condom R,Zoulim F,Durantel D,Hantz O

更新日期：2008-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infections cause congenital birth defects and disease in immunosuppressed individuals. Antiviral compounds can control infection yet their use is restricted due to concerns of toxicity and the emergence of drug resistant strains. We have evaluated the impact of an RNA Polymerase I (Pol I) ...

journal_title：Antiviral research

authors： Westdorp KN,Terhune SS

更新日期：2018-05-01 00:00:00

abstract：:There is a pressing need for new vaccines against alphaviruses, which can cause fatal encephalitis (Venezuelan equine encephalitis virus (VEEV) and others) and severe arthralgia (e.g. Chikungunya virus, CHIKV). These positive-strand RNA viruses are diverse and evolve rapidly, meaning that the sequence of any vaccine s...

journal_title：Antiviral research

authors： Baker WS,Negi S,Braun W,Schein CH

更新日期：2020-10-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given or...

journal_title：Antiviral research

authors： Lawitz E,Godofsky E,Rouzier R,Marbury T,Nguyen T,Ke J,Huang M,Praestgaard J,Serra D,Evans TG

更新日期：2011-03-01 00:00:00

abstract：:In the event of a bioterror attack with variola virus (smallpox), exposure may only be identified following onset of fever. To determine if antiviral therapy with brincidofovir (BCV; CMX001) initiated at, or following, onset of fever could prevent severe illness and death, a lethal rabbitpox model was used. BCV is in ...

journal_title：Antiviral research

authors： Grossi IM,Foster SA,Gainey MR,Krile RT,Dunn JA,Brundage T,Khouri JM

更新日期：2017-07-01 00:00:00

abstract：:Approximately 170 million people worldwide are chronic carriers of Hepatitis C virus (HCV). To date, there is no prophylactic vaccine available against HCV. The standard-of-care therapy for HCV infection involves a combination of pegylated interferon-α and ribavirin. This therapy, which is commonly associated with sid...

journal_title：Antiviral research

authors： Ip PP,Nijman HW,Wilschut J,Daemen T

更新日期：2012-10-01 00:00:00

abstract：:Lactoferrin (LF), a member of the transferrin family, is a bi-globular protein secreted in milk, saliva, tears, seminal fluid, endocervix and vaginal secretions. LF is an important player in the defence against pathogenic microorganisms and has also been shown to have activity against several viruses including herpesv...

journal_title：Antiviral research

authors： Drobni P,Näslund J,Evander M

更新日期：2004-10-01 00:00:00

abstract：:Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mort...

journal_title：Antiviral research

authors： Leblebicioglu H,Ozaras R,Irmak H,Sencan I

更新日期：2016-02-01 00:00:00

abstract：:Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune de...

journal_title：Antiviral research

authors： Morrey JD,Warren RP,Okleberry KM,Burger RA,Chirigos MA,Sidwell RW

更新日期：1991-01-01 00:00:00

abstract：:Despite an urgent medical need, a broadly effective anti-viral therapy for the treatment of infections with hepatitis C viruses (HCVs) has yet to be developed. One of the approaches to anti-HCV drug discovery is the design and development of specific small molecule drugs to inhibit the proteolytic processing of the HC...

journal_title：Antiviral research

authors： Kwong AD,Kim JL,Rao G,Lipovsek D,Raybuck SA

更新日期：1999-02-01 00:00:00

abstract：:While the combination of zidovudine and didanosine is used in HIV-infected patients with more advanced disease, the possibility of a pharmacokinetic interaction between these two drugs remains controversial. Zidovudine doses of 50, 100, and 200 mg, combined with 67, 167, and 250 mg of didanosine were evaluated in 11 a...

journal_title：Antiviral research

authors： Morse GD,Shelton MJ,Ho M,Bartos L,DeRemer M,Ragni M

更新日期：1995-08-01 00:00:00

abstract：:The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptom...

journal_title：Antiviral research

authors： Bavagnoli L,Campanini G,Forte M,Ceccotti G,Percivalle E,Bione S,Lisa A,Baldanti F,Maga G

更新日期：2019-11-01 00:00:00

abstract：:The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-...

journal_title：Antiviral research

authors： Pitts JD,Li PC,de Wispelaere M,Yang PL

更新日期：2017-11-01 00:00:00

abstract：:RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...

journal_title：Antiviral research

authors： Park IH,Kwon YC,Ryu WS,Ahn BY

更新日期：2014-04-01 00:00:00

abstract：:Prunellin, an anti-HIV active compound, was isolated from aqueous extracts of the Chinese medicinal herb, Prunella vulgaris, and purified to chromatographic homogeneity. Infrared and NMR spectroscopy identified prunellin as a polysaccharide. Elemental analyses, precipitation with calcium(II), barium(II), or 9-aminoacr...

journal_title：Antiviral research

authors： Tabba HD,Chang RS,Smith KM

更新日期：1989-06-01 00:00:00

abstract：:While combination antiretroviral therapy (cART) has successfully converted HIV to a chronic but manageable infection in many parts of the world, HIV continues to persist within latent cellular reservoirs, which can become reactivated at any time to produce infectious virus. New therapies are therefore needed not only ...

journal_title：Antiviral research

authors： Andersen RJ,Ntie-Kang F,Tietjen I

更新日期：2018-10-01 00:00:00

abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...

journal_title：Antiviral research

authors： Ovcharenko AV,Zhirnov OP

更新日期：1994-02-01 00:00:00

abstract：:Pyrosequencing has been successfully used to monitor resistance in influenza A viruses to the first class of anti-influenza drugs, M2 blockers (adamantanes). In contrast to M2 blockers, resistance to neuraminidase (NA) inhibitors (NAIs) is subtype- and drug-specific. Here, we designed a pyrosequencing assay for detect...

journal_title：Antiviral research

authors： Deyde VM,Okomo-Adhiambo M,Sheu TG,Wallis TR,Fry A,Dharan N,Klimov AI,Gubareva LV

更新日期：2009-01-01 00:00:00

abstract：:Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism o...

journal_title：Antiviral research

authors： Richman DD

更新日期：2006-09-01 00:00:00

abstract：:Antigen presenting liposomes (APLs) containing both liposome encapsulated (44%) and free (56%) recombinant glycoprotein D of herpes simplex virus type-2 (rgD-2) were characterized with respect to the interaction of the antigen with the lipid bilayer and the biological activities provided by each form of rgD-2. We foun...

journal_title：Antiviral research

authors： Ho RJ,Burke RL,Merigan TC

更新日期：1990-04-01 00:00:00

abstract：UNLABELLED:This paper presents the public health rationale for multipurpose prevention technologies (MPTs) for sexual and reproductive health (SRH) based on regional trends in demographic and SRH indicators. It then distils important lessons gleaned from the introduction of contraceptive and reproductive health product...

journal_title：Antiviral research

authors： Brady M,Manning J

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cases of sustained-virological response (SVR or cure) after an ultra-short duration (≤27 days) of direct-acting antiviral (DAA)-based therapy, despite HCV being detected at end of treatment (EOT), have been reported. Established HCV mathematical models that predict the treatment duration required to achieve ...

journal_title：Antiviral research

authors： Goyal A,Lurie Y,Meissner EG,Major M,Sansone N,Uprichard SL,Cotler SJ,Dahari H

更新日期：2017-08-01 00:00:00

abstract：:To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion (CCF) assay were identified. These mAbs demonstrated potent antivira...

journal_title：Antiviral research

authors： Ji C,Brandt M,Dioszegi M,Jekle A,Schwoerer S,Challand S,Zhang J,Chen Y,Zautke L,Achhammer G,Baehner M,Kroetz S,Heilek-Snyder G,Schumacher R,Cammack N,Sankuratri S

更新日期：2007-05-01 00:00:00

abstract：:The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in m...

journal_title：Antiviral research

authors： Idowu AD,Fraser-Smith EB,Poffenberger KL,Herman RC

更新日期：1992-02-01 00:00:00