Abstract：
:The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-(4-hydroxyphenyl) retinamide (fenretinide or 4-HPR) as an antiviral compound that inhibits dengue virus 2 (DV2) and other flaviviruses by limiting the steady-state accumulation of viral RNA. Here we show that 4-HPR potently inhibits ZIKV in mammalian cell culture and significantly reduces both serum viremia and brain viral burden in a murine model of ZIKV infection. Consistent with previous observations with dengue virus, this antiviral activity is associated with a significant reduction in the steady-state abundance of viral genomic RNA. We show this reduction is due to a major decrease in the rate of viral RNA synthesis, though not via direct inhibition of the activity of the viral replicase. These results establish 4-HPR's mode of action against DV and ZIKV and, taken with previous clinical trials that established 4-HPR's safety and tolerability, illustrate the potential utility of 4-HPR as an agent for treatment of ZIKV infection.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Pitts JD,Li PC,de Wispelaere M,Yang PLdoi
10.1016/j.antiviral.2017.10.014subject
Has Abstractpub_date
2017-11-01 00:00:00pages
124-130eissn
0166-3542issn
1872-9096pii
S0166-3542(17)30613-7journal_volume
147pub_type
杂志文章abstract：:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2003.10.004
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abstract：:More than 50% of a group of healthy homosexuals in Israel were found to have an activated interferon (IFN) system as evidenced by markedly elevated blood IFN levels, increased in vitro production of IFN by unstimulated peripheral blood mononuclear cells and HuIFN-alpha and HuIFN-gamma production by appropriately stimu...
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pub_type： 杂志文章
doi：10.1016/0166-3542(90)90067-h
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2015.01.013
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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更新日期：2009-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1992-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2010.08.004
更新日期：2010-10-01 00:00:00
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doi：10.1016/j.antiviral.2018.09.005
更新日期：2018-12-01 00:00:00
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doi：10.1016/j.antiviral.2019.104677
更新日期：2020-02-01 00:00:00
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更新日期：1989-06-01 00:00:00
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更新日期：2019-07-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2011.01.005
更新日期：2011-03-01 00:00:00
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journal_title：Antiviral research
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更新日期：2018-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.12.007
更新日期：2005-04-01 00:00:00
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journal_title：Antiviral research
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更新日期：2017-06-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2015.03.001
更新日期：2015-06-01 00:00:00
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journal_title：Antiviral research
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doi：10.1016/j.antiviral.2016.12.001
更新日期：2017-02-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2011.09.002
更新日期：2011-12-01 00:00:00
