当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus.

Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus.

Abstract：

:MicroRNA-122 (miR-122) is involved in the pathogenesis of several liver diseases, including chronic hepatitis B infection and hepatocellular carcinoma. This study aimed to explore the potential role of miR-122 in the interferon (IFN)-mediated suppression of hepatitis B virus (HBV) in hepatocytes. We found that elevated expression of suppressor of cytokine signaling 3 (SOCS3) following HBV infection, contributed to the inactivation of the IFN signaling pathway. Based on previous studies from our laboratory showing that miR-122 can modulate type I IFN expression by inhibiting SOCS1 expression, we analyzed the SOCS3 mRNA sequence for putative miR-122 binding sites. We demonstrate that miR-122 inhibits SOCS3 expression by targeting the 3'-untranslated region of the SOCS3 mRNA within the region 1887-1910 nucleotides. Finally, we demonstrate that significantly increased levels of IFN lead to decreased HBV expression in miR-122 mimic-treated Huh7 cells, whereas inhibition of endogenous miR-122 leads to enhanced viral production, owing to a marked decrease in IFN expression. Taken together, our results demonstrate that miR-122 down-regulates SOCS3, thus positively affecting the anti-HBV efficiency of endogenous type I IFN. Our study suggests that suppression of miR-122 induced by HBV infection, leads to the inactivation of IFN expression, which in turn enhances HBV replication, contributing to viral persistence and hepatocarcinogenesis.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Gao D,Zhai A,Qian J,Li A,Li Y,Song W,Zhao H,Yu X,Wu J,Zhang Q,Kao W,Wei L,Zhang F,Zhong Z

doi

10.1016/j.antiviral.2015.03.001

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

20-8

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(15)00053-4

journal_volume

118

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Emetine protects mice from enterovirus infection by inhibiting viral translation.

    abstract：:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104650

    authors： Tang Q,Li S,Du L,Chen S,Gao J,Cai Y,Xu Z,Zhao Z,Lan K,Wu S

    更新日期：2020-01-01 00:00:00

  • Comparison of human cytomegalovirus DNA polymerase activity for ganciclovir-resistant and -sensitive clinical strains.

    abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(00)00063-2

    authors： Kariya M,Mori S,Eizuru Y

    更新日期：2000-02-01 00:00:00

  • Drastic decrease of transcription activity due to hypermutated long terminal repeat (LTR) region in different HIV-1 subtypes and recombinants.

    abstract：:Transcriptional activation of HIV-1 gene expression is partially controlled by the interaction between viral and cellular transcription factors acting at HIV-1 long terminal repeat (LTR) sequences. HIV-1 subtyping at LTR region and nucleotide LTR variability from clinical samples in 48 subjects carrying different HIV-...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.08.007

    authors： de Arellano ER,Alcamí J,López M,Soriano V,Holguín A

    更新日期：2010-11-01 00:00:00

  • Novel nucleoside strategies for anti-HIV and anti-HSV therapy.

    abstract：:This mini-review describes the structure-activity relationships of several series of new nucleoside analogues. It also points to the possibilities of finding new molecular modifications which could lead to antivirals with activity both against human immunodeficiency viruses (HIV) and herpesviruses. ...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/0166-3542(92)90052-7

    authors： Herdewijn PA

    更新日期：1992-07-01 00:00:00

  • Antiviral action of 5-amino-2-(2-dimethyl-aminoethyl)benzo-[de]-isoquinolin-1,3-dion e.

    abstract：:A newly synthesized imide derivative of 3-nitro-1,8-naphthalic acid, 5-amino-2-(2-dimethylaminoethyl)benzo-[de]-isoquinolin-1,3-dione (designated M-FA-142), was tested on chick embryo cells against herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), and on Vero cells against African swine fever virus (ASFV). ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(84)90018-4

    authors： García Gancedo A,Gil-Fernández C,Vilas P,Pérez S,Rodriguez F,Paez E,Braña MF,Roldán CM

    更新日期：1984-08-01 00:00:00

  • Distinct patterns of cellular immune response elicited by influenza non-adjuvanted and AS03-adjuvanted monovalent H1N1(pdm09) vaccine.

    abstract：:The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels of anti-H1N1 antibodies at day30 after vaccination, higher reactivity was observed in AV at day180. While AV indu...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.05.009

    authors： Giarola-Silva S,Coelho-Dos-Reis JGA,Mourão MM,Campi-Azevedo AC,Nakagaki Silva EE,Luiza-Silva M,Martins MA,Silveira-Cassette ACO,Batista MA,Peruhype-Magalhães V,Antonelli LRDV,Leite Ribeiro JG,Elói-Santos SM,Machado AV,Teixeir

    更新日期：2017-08-01 00:00:00

  • Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.

    abstract：:Several nucleoside reverse transcriptase inhibitors are associated with mitochondrial toxicity resulting from inhibition of DNA polymerase-gamma. This study compared the effects on mitochondrial DNA of apricitabine (previously referred to as AVX754 or SPD754), a novel cytidine analogue under development for the treatm...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2007.05.004

    authors： de Baar MP,de Rooij ER,Smolders KG,van Schijndel HB,Timmermans EC,Bethell R

    更新日期：2007-10-01 00:00:00

  • Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants.

    abstract：:The ability to control plant viral diseases with chemicals has great potential value for agriculture, but few chemicals are available to date due to the difficulty in obtaining effective drugs. IMP dehydrogenase is an enzyme which catalyzes the conversion of inosine 5'-monophosphate to xanthosine 5'-monophosphate in t...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.10.007

    authors： Panattoni A,D'Anna F,Triolo E

    更新日期：2007-03-01 00:00:00

  • Inhibitory activity of the new adamantane derivative N,N'-bis(ethylene)-P(1-adamantyl)-phosphonic diamide against Rous sarcoma virus.

    abstract：:A new adamantane derivative N,N'-bis (ethylene)P(1-adamantyl)-phosphonis diamide, was found to inhibit Rous sarcoma virus replication in much the same manner as reported for the parent compound, 1-adamantanamine hydrochloride. ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(81)90017-6

    authors： McGraw TL,Cates LA,Daley LS,Chen YC

    更新日期：1981-11-01 00:00:00

  • No reduction of HCV viral load in HIV patients co-infected with HCV genotype 1 during a 30 days course of nitazoxanide monotherapy.

    abstract：:There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infect...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.10.006

    authors： Laufer N,Abusamra L,Bolcic F,Gun A,Rolón MJ,Pérez H,Krolewiecki A,Salomón H,Quarleri J,Cahn P

    更新日期：2011-12-01 00:00:00

  • A new contained human immunodeficiency virus type 1 host cell system for evaluation of antiviral activities of interferons and other agents in vitro.

    abstract：:HIV-host infection systems in vitro are important in the pre-clinical assessment of anti-retroviral drug activity. The present report describes the development of a new HIV-host model comprised of an epithelial cell line of HeLa lineage (HeLa-1), transfected with expression vectors bearing tat and rev (TART) genes of ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(99)00014-5

    authors： Moussazadeh M,Hua J,Sidhu MK,Zhao XX,Fitzgibbon JE,Liao MJ,Rashidbaigi A

    更新日期：1999-07-01 00:00:00

  • Suppression of BK virus replication and cytopathic effect by inhibitors of prokaryotic DNA gyrase.

    abstract：:Nalidixic acid and oxolinic acid, two antibacterial agents known to inhibit bacterial DNA gyrase, are shown to suppress the replication, as well as the cytopathic effect, of BK virus in Vero cell cultures. The inhibition of virus replication was detectable at day 4 post infection in cultures which had been continuousl...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(88)90004-6

    authors： Portolani M,Pietrosemoli P,Cermelli C,Mannini-Palenzona A,Grossi MP,Paolini L,Barbanti-Brodano G

    更新日期：1988-04-01 00:00:00

  • Immunogenicity and protective efficacy of recombinant major envelope protein (rH3L) of buffalopox virus in animal models.

    abstract：:Buffalopox virus, a zoonotic Indian vaccinia-like virus, is responsible for contagious disease affecting mainly buffaloes, cattle and humans. H3L gene, encoding for an immunodominant major envelope protein of intracellular mature virion of orthopoxviruses, is highly conserved and found to elicit neutralizing antibodie...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.12.004

    authors： Kumar A,Yogisharadhya R,Venkatesan G,Bhanuprakash V,Shivachandra SB

    更新日期：2016-02-01 00:00:00

  • Nanobodies®: new ammunition to battle viruses.

    abstract：:In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is still unclear what the evolutionary advantage of such heavy chain-only a...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2011.09.002

    authors： Vanlandschoot P,Stortelers C,Beirnaert E,Ibañez LI,Schepens B,Depla E,Saelens X

    更新日期：2011-12-01 00:00:00

  • Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005.

    abstract：:The prevention and control of disease caused by seasonal and potential pandemic influenza viruses is currently managed by the use influenza vaccines and antivirals. The adamantanes (amantadine and rimantadine) were the first antivirals licensed for use against influenza A viruses and have been used extensively in some...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.08.002

    authors： Barr IG,Hurt AC,Iannello P,Tomasov C,Deed N,Komadina N

    更新日期：2007-02-01 00:00:00

  • Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo.

    abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2021.105014

    authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

    更新日期：2021-01-07 00:00:00

  • Patterns of hepatocellular carcinoma development in hepatitis B virus and hepatitis C virus related cirrhosis.

    abstract：:To compare incidence, risk factors and morphologic pattern of hepatocellular carcinoma (HCC) development in hepatitis B virus (HBV) and hepatitis C virus (HCV) related cirrhosis, 401 patients were followed prospectively by periodic ultrasound examination for 14-189 months (mean: 84.8+/-36.7). During follow-up, 77 (19....

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(01)00185-1

    authors： Benvegnù L,Alberti A

    更新日期：2001-11-01 00:00:00

  • Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme.

    abstract：:Chikungunya virus (CHIKV) is an arthropod-borne alphavirus. Alphaviruses are positive strand RNA viruses that require a 5' cap structure to direct translation of the viral polyprotein and prevent degradation of the viral RNA genome by host cell nucleases. Formation of the 5' RNA cap is orchestrated by the viral protei...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.03.013

    authors： Feibelman KM,Fuller BP,Li L,LaBarbera DV,Geiss BJ

    更新日期：2018-06-01 00:00:00

  • RNA interference inhibits replication of tick-borne encephalitis virus in vitro.

    abstract：:Each year, up to 10,000 cases of infections with the flavivirus tick-borne encephalitis (TBE) virus that affect the central nervous system are reported in Europe and Asia. Due to the potentially severe adverse effects of post-exposure prophylaxis with TBE virus hyperimmunoglobulin, TBE can currently only be treated sy...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.10.023

    authors： Achazi K,Patel P,Paliwal R,Radonić A,Niedrig M,Donoso-Mantke O

    更新日期：2012-01-01 00:00:00

  • The nucleocapsid of the hepatitis B virus: a remarkable immunogenic structure.

    abstract：:The hepatitis B virus nucleocapsid or core antigen is extremely immunogenic during infection and after immunization. This review summarizes several features of the nucleocapsid which explain this exceptionally high immunogenicity: a unique three-dimensional folding, the presence of a region that interacts with immunog...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2003.08.011

    authors： Vanlandschoot P,Cao T,Leroux-Roels G

    更新日期：2003-10-01 00:00:00

  • Recent progress in henipavirus research: molecular biology, genetic diversity, animal models.

    abstract：:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2012.05.008

    authors： Rockx B,Winegar R,Freiberg AN

    更新日期：2012-08-01 00:00:00

  • HIV protease inhibitors block adipogenesis and increase lipolysis in vitro.

    abstract：:AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not clear. Thus, the affects of PIs on adipocyte differentiation were examined in vitro using C3H10T1/2 stem cells. In these cells the PIs, nelfinavir, saquinavir, ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(00)00102-9

    authors： Lenhard JM,Furfine ES,Jain RG,Ittoop O,Orband-Miller LA,Blanchard SG,Paulik MA,Weiel JE

    更新日期：2000-08-01 00:00:00

  • Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.

    abstract：:The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptom...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104593

    authors： Bavagnoli L,Campanini G,Forte M,Ceccotti G,Percivalle E,Bione S,Lisa A,Baldanti F,Maga G

    更新日期：2019-11-01 00:00:00

  • The use of ampligen alone and in combination with ganciclovir and coumermycin A1 for the treatment of ducks congenitally-infected with duck hepatitis B virus.

    abstract：:Ampligen, a known immunomodulator and interferon inducer, was used alone and in combination with other antiviral agents to treat ducks congenitally-infected with duck hepatitis B virus. These antiviral agents included the conventional nucleoside analogue ganciclovir and the prokaryotic DNA gyrase B inhibitor coumermyc...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(93)90051-j

    authors： Niu J,Wang Y,Dixon R,Bowden S,Qiao M,Einck L,Locarnini S

    更新日期：1993-06-01 00:00:00

  • Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo.

    abstract：:The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in m...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(92)90048-a

    authors： Idowu AD,Fraser-Smith EB,Poffenberger KL,Herman RC

    更新日期：1992-02-01 00:00:00

  • Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir.

    abstract：:Human influenza viruses isolated from Australasia (Australia and New Zealand) and South East Asia were analysed to determine their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir. A total of 532 strains isolated between 1998 and 2002 were tested using a fluorescence-based assay to measure the relative...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2003.11.008

    authors： Hurt AC,Barr IG,Hartel G,Hampson AW

    更新日期：2004-04-01 00:00:00

  • Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir.

    abstract：:Mycophenolate mofetil (MMF), a therapeutically used inhibitor of inosine monophosphate dehydrogenase is hydrolyzed to its active metabolite mycophenolic acid (MPA) in vivo. MPA exhibits anti-HIV activity in vitro. We tested MPA alone and in combination with abacavir (ABC), didanosine (DDI), lamivudine (3TC) and tenofo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(02)00006-2

    authors： Hossain MM,Coull JJ,Drusano GL,Margolis DM

    更新日期：2002-07-01 00:00:00

  • T cell responses in hepatitis C virus infection: historical overview and goals for future research.

    abstract：:Hepatitis C virus (HCV)-specific T cells are key factors in the outcome of acute HCV infection and in protective immunity. This review recapitulates the steps that immunologists have taken in the past 25years to dissect the role of T cell responses in HCV infection. It describes technical as well as disease-specific c...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2014.11.009

    authors： Holz L,Rehermann B

    更新日期：2015-02-01 00:00:00

  • Maraviroc Clinical Test (MCT) as an alternative tool to decide CCR5-antagonists prescription in naïve HIV-infected patients.

    abstract：:Our aim was to analyze the virological response to a combined antiretroviral therapy started after Maraviroc Clinical Test (MCT) in naïve HIV-infected patients. Forty-one patients were exposed to MCT, based on an 8-day MVC monotherapy. If undetectability or a viral load reduction >1 log10 HIV-RNA copies/ml was achieve...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.06.018

    authors： Genebat M,de Pablo-Bernal RS,Pulido I,Jiménez-Mejías ME,Martínez O,Pacheco YM,Raffi-El-Idrissi Benhia M,Abad MA,Ruiz-Mateos E,Leal M

    更新日期：2015-09-01 00:00:00

  • Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus.

    abstract：:Sixteen herpes simplex virus type 1 (HSV-1) and four type 2 (HSV-2) isolates resistant to acyclovir (ACV) were characterized retrospectively for drug resistance. Phenotypic testing was performed by means of tetrazolium reduction assay and genotypic analysis was carried out by sequencing of thymidine kinase (TK) and DN...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.03.002

    authors： Sauerbrei A,Deinhardt S,Zell R,Wutzler P

    更新日期：2010-06-01 00:00:00