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Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.

Abstract：

:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly assigned to one of these three regimens. Patients were followed monthly for 6 months and every 3 months thereafter. Outcomes of interest included: (1) mortality; (2) retinitis progression; (3) change in retinal area affected by CMV; (4) loss of visual field; (5) loss of visual acuity; (6) quality of life; and (7) treatment side effects.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Jabs DA

doi

10.1016/0166-3542(95)00921-3

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

69-71

issue

1

eissn

0166-3542

issn

1872-9096

pii

0166354295009213

journal_volume

29

pub_type

临床试验,杂志文章,随机对照试验

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