当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > The cooperative effect of interferon-alpha and ribavirin on subacute sclerosing panencephalitis (SSPE) virus infections, in vitro and in vivo.

The cooperative effect of interferon-alpha and ribavirin on subacute sclerosing panencephalitis (SSPE) virus infections, in vitro and in vivo.

Abstract：

:We studied the effects of two antiviral agents, human interferon-alpha (IFN-alpha) and ribavirin, on subacute sclerosing panencephalitis (SSPE) virus infections in hamsters. By intracranial administration, IFN-alpha alone improved the survival of infected hamsters by 20% at a dose of 6 x 10(4) IU/kg every other day for 10 days. When the dose of IFN-alpha was increased incrementally to 6 x 10(6) IU/kg, the survival rate increased by 70% in a dose-dependent manner. The combination of IFN-alpha and ribavirin had a synergic inhibitory effect on the replication of SSPE virus in cell culture. Combination of IFN-alpha (at a dose of 6 x 10(5) IU/kg) with ribavirin (at a dose of 1 mg/kg) completely prevented mortality. This was significantly better than either IFN-alpha or ribavirin monotherapy (p < 0.05). Under the conditions used, IFN-alpha did not enhance the toxicity of ribavirin in hamsters. Intraventricular administration of high dose IFN-alpha and ribavirin may have potential usefulness in the treatment of patients with SSPE.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Takahashi T,Hosoya M,Kimura K,Ohno K,Mori S,Takahashi K,Shigeta S

doi

10.1016/s0166-3542(97)00055-7

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

29-35

issue

1

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(97)00055-7

journal_volume

37

pub_type

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