Abstract:
:The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (GCV) showed concentration-dependent inhibitory properties from 0.05 to 3.6 μM and 0.01 to 1.0 μM, respectively. Tricin had no virucidal effects on cell-free HCMV. Treatment with tricin 1h before, or 1h or 3h after viral infection significantly suppressed HCMV replication. Moreover, tricin inhibited the expression of immediate early (IE) 2 mRNA and DNA polymerase (UL54) mRNA in HCMV-infected cells. Western blot analysis also demonstrated that tricin decreased the expression of IE antigen (especially IE2) and cyclooxygenase 2 (COX-2) expression in HCMV-infected cells. In the presence of tricin, prostaglandin E2 (PGE2) accumulation by HCMV infection was completely inhibited. These results suggest that tricin is a novel compound with potential COX inhibitor-dependent anti-HCMV activity.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Akuzawa K,Yamada R,Li Z,Li Y,Sadanari H,Matsubara K,Watanabe K,Koketsu M,Tuchida Y,Murayama Tdoi
10.1016/j.antiviral.2011.06.014subject
Has Abstractpub_date
2011-09-01 00:00:00pages
296-303issue
3eissn
0166-3542issn
1872-9096pii
S0166-3542(11)00356-1journal_volume
91pub_type
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