当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication.

Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication.

Abstract：

:Prostaglandins are potentially useful antiviral agents, however their mechanism of action is unclear. Recent evidence suggests that RNA transcription of vesicular stomatitis virus (VSV) is inhibited by prostaglandins (Bader and Ankel, J. Gen. Virol. 71, 2823-2832, 1990). Prostaglandins are known to have multiple effects on cells which may or may not be related to their antiviral action. We examined the effects of prostaglandins on cells and on VSV RNA polymerase in vitro to seek the mechanism of antiviral action. Actinomycin D inhibited cellular RNA synthesis but failed to block the antiviral activity of prostaglandins on VSV. Thus induction of host cell RNA transcription is not involved in the antiviral action. Neither modulation of the cellular glutathione level by prostaglandins nor formation of prostaglandin-glutathione conjugates was required for the antiviral action. The relative inhibition of VSV RNA polymerase in vitro by prostaglandins with different structures correlated to inhibition of VSV replication in infected cells. This result indicates that the same step in VSV replication is inhibited by prostaglandins both in the in vitro RNA polymerase assay and in the infected cell.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Parker J,Ahrens PB,Ankel H

doi

10.1016/0166-3542(94)00067-i

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

83-96

issue

1

eissn

0166-3542

issn

1872-9096

pii

016635429400067I

journal_volume

26

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Antiviral activity of brincidofovir on parvovirus B19.

    abstract：:Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus responsible for a wide range of clinical manifestations. Currently there is no approved antiviral therapy for parvovirus infection. The acyclic nucleoside phosphonate cidofovir (CDV) has been demonstrated to inhi...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.12.003

    authors： Bua G,Conti I,Manaresi E,Sethna P,Foster S,Bonvicini F,Gallinella G

    更新日期：2019-02-01 00:00:00

  • Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine.

    abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(85)90048-8

    authors： Field HJ

    更新日期：1985-06-01 00:00:00

  • Interactions among antiviral drugs acting late in the replication cycle of human cytomegalovirus.

    abstract：:This study describes the extent of cross-resistance and interactions for selected inhibitors of human cytomegalovirus (HCMV) DNA synthesis and DNA processing. HCMV isolates resistant to the benzimidazole D-ribonucleoside viral DNA processing inhibitors TCRB and BDCRB were sensitive to BAY 38-4766, a non-nucleoside inh...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(02)00094-3

    authors： Evers DL,Komazin G,Shin D,Hwang DD,Townsend LB,Drach JC

    更新日期：2002-10-01 00:00:00

  • Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.

    abstract：:3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(87)90002-7

    authors： Vrang L,Bazin H,Remaud G,Chattopadhyaya J,Oberg B

    更新日期：1987-03-01 00:00:00

  • Effect of cyclosporin A on the production of interferon by human peripheral blood leukocytes in vitro.

    abstract：:Cyclosporin A (CsA) was assessed for its effect on the production of antiviral activity by human peripheral blood leukocytes (PBL). CsA markedly reduced the production of interferon-gamma (IFN-gamma) in response to stimulation with lectin mitogens, bacterial products, alloantigens, or Epstein-Barr virus (EBV)-transfor...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(82)90006-7

    authors： Abb J,Abb H,Deinhardt F

    更新日期：1982-12-01 00:00:00

  • Immune response to varicella-zoster virus before and after renal transplantation.

    abstract：BACKGROUND:Herpes zoster (HZ) risk is high in renal transplant recipients. Vaccination prior to transplantation may provide a useful strategy for the prevention of HZ in the posttranplantation period. However, it is not known whether immunity to varicella-zoster virus (VZV) is affected due to treatment surrounding tran...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104938

    authors： Rondaan C,de Joode AAE,Wang L,Siderius M,Raveling-Eelsing E,van Leer-Buter C,van Assen S,Bos NA,Westra J

    更新日期：2020-11-01 00:00:00

  • Inhibition of bovine immunodeficiency virus by anti-HIV-1 compounds in a cell culture-based assay.

    abstract：:The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(96)00990-4

    authors： Tobin GJ,Ennis WH,Clanton DJ,Gonda MA

    更新日期：1996-12-01 00:00:00

  • Physical and biological characterization of antigen presenting liposome formulations: relative efficacy for the treatment of recurrent genital HSV-2 in guinea pigs.

    abstract：:Antigen presenting liposomes (APLs) containing both liposome encapsulated (44%) and free (56%) recombinant glycoprotein D of herpes simplex virus type-2 (rgD-2) were characterized with respect to the interaction of the antigen with the lipid bilayer and the biological activities provided by each form of rgD-2. We foun...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90037-8

    authors： Ho RJ,Burke RL,Merigan TC

    更新日期：1990-04-01 00:00:00

  • Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

    abstract：:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylami...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90031-2

    authors： Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

    更新日期：1990-09-01 00:00:00

  • Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.

    abstract：:We have analyzed a panel of protein kinase inhibitors (PKIs) and found that some indolocarbazoles (Gö6976, K252a, K252c) proved to be highly effective inhibitors of GCV-sensitive and -resistant human cytomegalovirus (HCMV) strains, but did not show any effect against herpes simplex virus. Antiviral activity was determ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(00)00118-2

    authors： Zimmermann A,Wilts H,Lenhardt M,Hahn M,Mertens T

    更新日期：2000-10-01 00:00:00

  • Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles.

    abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guilla...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.04.016

    authors： Albulescu IC,Kovacikova K,Tas A,Snijder EJ,van Hemert MJ

    更新日期：2017-07-01 00:00:00

  • The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors.

    abstract：:Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic chori...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104558

    authors： Kim YJ,Cubitt B,Chen E,Hull MV,Chatterjee AK,Cai Y,Kuhn JH,de la Torre JC

    更新日期：2019-09-01 00:00:00

  • Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection.

    abstract：:Therapeutic strategies controlling human cytomegalovirus (hCMV) infection are limited due to adverse side effects and emergence of antiviral resistance variants. A compound being evaluated for treating hCMV disease is maribavir (MBV) which disrupts replication by inhibiting the viral kinase pUL97. Previous studies hav...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.09.011

    authors： Reitsma JM,Terhune SS

    更新日期：2013-11-01 00:00:00

  • Infection of neuroblastoma cells by rabies virus is modulated by the virus titer.

    abstract：:Rabies is a lethal viral infection that can affect almost all mammals, including humans. To better understand the replication of Rabies lyssavirus, we investigated if the viral load in brains naturally infected with rabies influences viral internalization and viral growth kinetics in neuroblastoma cells, and if the vi...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.11.003

    authors： Fuoco NL,Dos Ramos Silva S,Fernandes ER,Luiz FG,Ribeiro OG,Katz ISS

    更新日期：2018-01-01 00:00:00

  • Clinical management and infection control of SARS: lessons learned.

    abstract：:The outbreak of severe acute respiratory syndrome (SARS) in 2003 was the first emergence of an important human pathogen in the 21st century. Responding to the epidemic provided clinicians with extensive experience in diagnosing and treating a novel respiratory viral disease. In this article, we review the experience o...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2013.08.016

    authors： Cheng VC,Chan JF,To KK,Yuen KY

    更新日期：2013-11-01 00:00:00

  • Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation.

    abstract：:Stilbenoids including resveratrol contain the basic structural unit of 1,2-diphenylethylene. Naturally occurring stilbenoids have broad structural features due to oligomerization and modifications and some have demonstrated potent biological activities. In an effort to identify bioactive stilbenoids, we screened a gro...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.05.001

    authors： Chen X,Qiao H,Liu T,Yang Z,Xu L,Xu Y,Ge HM,Tan RX,Li E

    更新日期：2012-07-01 00:00:00

  • In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition.

    abstract：:Commercial vaccines against human papillomavirus (HPV) have low uptake due to parental autonomy, dosing regimen, cost, and cold chain storage requirements. Carrageenan (CG)-based formulations prevent HPV infection in vitro and in vivo but data are needed on the durability of anti-HPV activity and the effect of seminal...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.05.018

    authors： Rodríguez A,Kleinbeck K,Mizenina O,Kizima L,Levendosky K,Jean-Pierre N,Villegas G,Ford BE,Cooney ML,Teleshova N,Robbiani M,Herold BC,Zydowsky T,Fernández Romero JA

    更新日期：2014-08-01 00:00:00

  • Germacrone inhibits early stages of influenza virus infection.

    abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.09.021

    authors： Liao Q,Qian Z,Liu R,An L,Chen X

    更新日期：2013-12-01 00:00:00

  • Citrate-mediated disaggregation of rotavirus particles in RotaTeq vaccine.

    abstract：:For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2005.11.001

    authors： Peterson SE,Wang S,Ranheim T,Owen KE

    更新日期：2006-02-01 00:00:00

  • Inhibition of human parainfluenza virus type 3 infection by novel small molecules.

    abstract：:Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2007.09.001

    authors： Mao H,Thakur CS,Chattopadhyay S,Silverman RH,Gudkov A,Banerjee AK

    更新日期：2008-02-01 00:00:00

  • Discovery of dapivirine, a nonnucleoside HIV-1 reverse transcriptase inhibitor, as a broad-spectrum antiviral against both influenza A and B viruses.

    abstract：:The emergence of multidrug-resistant influenza viruses poses a persistent threat to public health. The current prophylaxis and therapeutic interventions for influenza virus infection have limited efficacy due to the continuous antigenic drift and antigenic shift of influenza viruses. As part of our ongoing effort to d...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.07.016

    authors： Hu Y,Zhang J,Musharrafieh RG,Ma C,Hau R,Wang J

    更新日期：2017-09-01 00:00:00

  • Inhibitory effects of tricin derivative from Sasa albo-marginata on replication of human cytomegalovirus.

    abstract：:The anti-human cytomegalovirus (HCMV) activity of tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative from Sasa albo-marginata, was studied in the human embryonic fibroblast cell line MRC-5. In a plaque assay, tricin and ganciclovir (GCV) showed concentration-dependent inhibitory properties from 0.05 to 3....

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.06.014

    authors： Akuzawa K,Yamada R,Li Z,Li Y,Sadanari H,Matsubara K,Watanabe K,Koketsu M,Tuchida Y,Murayama T

    更新日期：2011-09-01 00:00:00

  • Comparison of human cytomegalovirus DNA polymerase activity for ganciclovir-resistant and -sensitive clinical strains.

    abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(00)00063-2

    authors： Kariya M,Mori S,Eizuru Y

    更新日期：2000-02-01 00:00:00

  • Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection.

    abstract：:Favipiravir (T-705) is a broad spectrum antiviral which has been approved in Japan for the treatment of severe influenza virus infections. We reported earlier that favipiravir inhibits the in vitro replication of CHIKV and protects against disease progression in CHIKV-infected immunodeficient mice. We here explored wh...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.09.016

    authors： Abdelnabi R,Jochmans D,Verbeken E,Neyts J,Delang L

    更新日期：2018-01-01 00:00:00

  • Inhibition of heat-shock protein 90 reduces Ebola virus replication.

    abstract：:Ebola virus (EBOV), a negative-sense RNA virus in the family Filoviridae, is known to cause severe hemorrhagic fever in humans and other primates. Infection with EBOV causes a high mortality rate and currently there is no FDA-licensed vaccine or therapeutic treatment available. Recently, heat-shock protein 90 (Hsp90),...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.04.015

    authors： Smith DR,McCarthy S,Chrovian A,Olinger G,Stossel A,Geisbert TW,Hensley LE,Connor JH

    更新日期：2010-08-01 00:00:00

  • In silico structure-based design and synthesis of novel anti-RSV compounds.

    abstract：:Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zi...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.08.003

    authors： Cancellieri M,Bassetto M,Widjaja I,van Kuppeveld F,de Haan CA,Brancale A

    更新日期：2015-10-01 00:00:00

  • Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery.

    abstract：:Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.03.011

    authors： Kneidinger D,Ibrišimović M,Lion T,Klein R

    更新日期：2012-06-01 00:00:00

  • Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication.

    abstract：:Human cytomegalovirus terminase complex cleaves the concatemeric genomic viral DNA into unit lengths during genome packaging and particle assembly. Terminase complex ATPase and endonuclease activity is provided by the viral protein pUL89. pUL89 is an attractive drug target because its activities are required for infec...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.01.015

    authors： Wang Y,Tang J,Wang Z,Geraghty RJ

    更新日期：2018-04-01 00:00:00

  • The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.

    abstract：:The bicyclams represent a new class of highly potent and selective HIV inhibitors. Time-of-addition experiments have previously shown that these compounds interfere with an early event in the viral replicative cycle. Additional experiments have now been carried out in order to investigate in more detail the mechanism ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(95)00837-3

    authors： De Vreese K,Reymen D,Griffin P,Steinkasserer A,Werner G,Bridger GJ,Esté J,James W,Henson GW,Desmyter J,Anné J,De Clercq I

    更新日期：1996-03-01 00:00:00

  • An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.

    abstract：:Epidermal growth factor receptor (EGFr) has been shown to be induced and activated in cells infected with HPV, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. To investigate this possibility, human foreskin tissue was infected with HPV11 and transplant...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.12.004

    authors： Parkinson T,Howett MK,Welsh PA,Patrick SD,Neely EB,Flanagan N,Pollack VA,Pustilnik LR,Moyer J,Perros M

    更新日期：2007-04-01 00:00:00