Abstract:
:With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational intravenous drug peramivir, and in combination treatments. In this study, we determined the impact of oseltamivir carboxylate on the binding affinity of peramivir/neuraminidase (NA) enzyme complex and vice versa. Influenza NA was incubated with peramivir and oseltamivir carboxylate alone and in combination. Dissociation rates of the enzyme-inhibitor complex measured in the presence of NA substrate for peramivir alone and the combination were similar, suggesting that peramivir competitively inhibits the neuraminidase enzyme and that oseltamivir carboxylate when added to peramivir does not impact the binding affinity of peramivir to the NA enzyme.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Bantia S,Upshaw R,Babu YSdoi
10.1016/j.antiviral.2011.06.010subject
Has Abstractpub_date
2011-09-01 00:00:00pages
288-91issue
3eissn
0166-3542issn
1872-9096pii
S0166-3542(11)00352-4journal_volume
91pub_type
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