Abstract：
:Tiazofurine (2-beta-D-ribofuranosylthiazole-4-carboxamide) was found to inhibit replication of barley stripe mosaic virus (BSMV) in barley and wheat plants. Treatment with this nucleoside analogue delayed and inhibited symptom development and suppressed virus multiplication. The most effective concentration applied twice as a foliar spray 3 h and one day after inoculation, was 10(-3) M. Decreased virus multiplication was obtained without marked phytotoxicity. Three weeks after treatment the antiviral effect declined.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Nagy PD,Gáborjányi R,Kovács L,Farkas Idoi
10.1016/0166-3542(89)90019-3subject
Has Abstractpub_date
1989-02-01 00:00:00pages
41-5issue
1eissn
0166-3542issn
1872-9096pii
0166-3542(89)90019-3journal_volume
11pub_type
杂志文章abstract：:HIV-1 integrase (IN) is one of three essential enzymes (along with reverse transcriptase and protease) encoded by the viral pol gene. IN mediates two critical reactions during viral replication; firstly 3'-end processing (3'EP) of the double-stranded viral DNA ends and then strand transfer (STF) which joins the viral ...
journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.antiviral.2009.11.004
更新日期：2010-01-01 00:00:00
abstract：:Double-stranded RNAs induce interferons and cause the development of antiviral and antiproliferative activities. Antiviral activity is related to the production of interferons and other proteins that stimulate various immunologic activities, which appear to contribute to their overall antiproliferative activity. The m...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.08.002
更新日期：2004-12-01 00:00:00
abstract：:Herpes simplex virus (HSV) types 1 and 2 are ubiquitous organisms that cause infections in human populations throughout the world. The clinical manifestations of HSV infections are varied, ranging from asymptomatic disease to life-threatening illness in neonates and immunocompromised hosts. This article will review th...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2003.09.006
更新日期：2004-02-01 00:00:00
abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104752
更新日期：2020-04-01 00:00:00
abstract：:Brivudin [(E)-5-(2-bromovinyl)-2'-deoxyuridine] is a nucleoside analogue with a high and selective antiviral activity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1). The double-blind, randomized study presented here compared efficacy and safety of oral brivudin 1 x 125 mg and acyclovir 5 ...
journal_title：Antiviral research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0166-3542(03)00065-2
更新日期：2003-06-01 00:00:00
abstract：:Flaviviruses constitute a public health concern because of their global burden and the lack of specific antiviral treatment. Here we investigated the antiviral activity of the alkaloid anisomycin against dengue (DENV) and Zika (ZIKV) viruses. At non-cytotoxic concentrations, anisomycin strongly inhibited the replicati...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104749
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:By modulating the antiviral immune response via vitamin D receptor, the active form of vitamin D (1,25-dihydroxyvitamin D, calcitriol) could play a central role in protection against respiratory virus infections. This in vitro study tested the hypothesis that respiratory viruses modulate vitamin D receptor e...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:The antiviral activity of antisense oligonucleotides corresponding to different regions of foot-and-mouth disease virus (FMDV) genome has been assessed in BHK-21 cells. The locations of the oligonucleotides used were: (i) two regions within the internal ribosome entry site (IRES), involved in the regulation of the tra...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(93)90082-t
更新日期：1993-09-01 00:00:00
abstract：:Infections by dengue virus (DENV) are increasing worldwide, with an urgent need for effective anti-DENV agents. We recently identified N-(4-hydroxyphenyl) retinamide (4-HPR), an anti-DENV agent effective against all 4 serotypes of DENV in cell culture, and in a lethal mouse model for DENV infection (Fraser et al., 201...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.03.006
更新日期：2016-06-01 00:00:00
abstract：:Human influenza viruses isolated from Australasia (Australia and New Zealand) and South East Asia were analysed to determine their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir. A total of 532 strains isolated between 1998 and 2002 were tested using a fluorescence-based assay to measure the relative...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2003.11.008
更新日期：2004-04-01 00:00:00
abstract：:A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of addition experiments indicate that TGG-II-23A functions at a stage of the HIV-1 life cycle at or near reverse transcription. Cell free assays confirmed that TGG-...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(93)90091-v
更新日期：1993-10-01 00:00:00
abstract：:Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential. In this study we report that mesuol and isomesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2005.02.006
更新日期：2005-06-01 00:00:00
abstract：:Fifty-nine US isolates of HSV-1 and HSV-2 obtained between 1998 and 2004 were tested for sensitivity to the helicase-primase inhibitor, pritelivir (AIC316, BAY 57-1293) by plaque-reduction assay. All isolates, which were collected prior to any clinical use of primase-helicase inhibitors, were sensitive and showed mean...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.08.024
更新日期：2013-11-01 00:00:00
abstract：:Hepatitis C virus (HCV) is a leading cause of chronic hepatitis and end-stage liver diseases. Mature HCV virions are bound by host-derived lipoproteins. Lack of an HCV vaccine warrants a major role of antiviral treatment in the global elimination of hepatitis C. Although direct-acting antivirals (DAAs) are replacing t...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104734
更新日期：2020-05-01 00:00:00
abstract：:The present study was undertaken to examine the potential of rectal route of immunization for induction of protective immunity in the female genital tract against genital herpes infection in mice. A single rectal immunization of female C57Bl/6 mice with live attenuated herpes simplex virus type 2 lacking thymidine kin...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.12.014
更新日期：2008-06-01 00:00:00
abstract：:Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex 1, which regulates factors involved in several crucial cellular functions and is required for CMV replication. However, it is not clear h...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2018.12.004
更新日期：2019-02-01 00:00:00
abstract：:Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza in preventing inte...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104785
更新日期：2020-06-01 00:00:00
abstract：:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2012.05.008
更新日期：2012-08-01 00:00:00
abstract：:For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2005.11.001
更新日期：2006-02-01 00:00:00
abstract：:LY253963, the sodium salt of 1,3,4-thiadiazol-2-ylcyanamide, was evaluated in tissue culture and in cotton rats for toxicity and antiviral efficacy against respiratory syncytial (RSV) and parainfluenza type 3 (PIV3) viruses. The selective index (ratio of the median toxic dose: median efficacious dose) of LY253963 in H...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(90)90005-r
更新日期：1990-10-01 00:00:00
abstract：:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for ca...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2014.06.009
更新日期：2014-09-01 00:00:00
abstract：:The global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012-13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104718
更新日期：2020-03-01 00:00:00
abstract：:The 27th International Conference on Antiviral Research (ICAR) was held in Raleigh, North Carolina, USA from May 12 to 16, 2014. This article summarizes the principal invited lectures. John Drach (Elion Award) described the early days of antiviral drugs and their novel modes of action. Piet Herdewijn (Holý Award) used...
journal_title：Antiviral research
pub_type：
doi：10.1016/j.antiviral.2014.08.009
更新日期：2014-11-01 00:00:00
abstract：:Oxymatrine (OMTR) is an anti-hepatitis drug used in China. Its mechanism of action is unknown. Recently, we found that OMTR inhibits hepatitis B virus (HBV) via down-regulating the expression of heat-stress cognate 70 (Hsc70), a host protein required for HBV DNA replication. Goal of this study was to assess the effect...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2011.01.005
更新日期：2011-03-01 00:00:00
abstract：:In this study we tested whether HIV-1 replication could be inhibited by stable RNAi-mediated knockdown of cellular co-factors. Cell lines capable of expressing shRNAs against 30 candidate co-factors implicated at different steps of the viral replication cycle were generated and analyzed for effects on cell viability a...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2010.11.005
更新日期：2011-01-01 00:00:00
abstract：:An immunogenic component was isolated from both the Illinois (propagated in young swine) and the Miller (cell culture-adapted) strains of porcine transmissible gastroenteritis (TGE) virus. The viral subunit was released from the virion by sonication and was separated from intact virus and other viral components by iso...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(83)90027-x
更新日期：1983-09-01 00:00:00
abstract：:Several nucleoside reverse transcriptase inhibitors are associated with mitochondrial toxicity resulting from inhibition of DNA polymerase-gamma. This study compared the effects on mitochondrial DNA of apricitabine (previously referred to as AVX754 or SPD754), a novel cytidine analogue under development for the treatm...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.05.004
更新日期：2007-10-01 00:00:00
abstract：:HIV-infected patients are at increased risk of decreased bone mineral density. Several studies have implicated antiretroviral therapy as a contributor to the decreased bone mineral density seen in treated HIV-1 patients. Whilst the exact molecular mechanisms underlying decreased bone density remain to be elucidated, i...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.12.003
更新日期：2007-04-01 00:00:00
abstract：:We have investigated viral breakthrough during a long-term culture of HIV-1-infected cells with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) 6-benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442), nevirapine and loviride (alpha-APA). When the compounds were examined for their inhibitory effects on HIV-1 (...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(96)00946-1
更新日期：1996-06-01 00:00:00
abstract：:Infectious bursal disease (IBD) leads to considerable economic losses for the poultry industry by inducing severe immunosuppression and high mortality in chickens. The objective of this study was to determine if RNA interference (RNAi) could be utilized to inhibit IBDV replication in vitro. We selected 3 short interfe...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.11.007
更新日期：2008-08-01 00:00:00
