当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir.

Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir.

Abstract：

:Human influenza viruses isolated from Australasia (Australia and New Zealand) and South East Asia were analysed to determine their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir. A total of 532 strains isolated between 1998 and 2002 were tested using a fluorescence-based assay to measure the relative inhibition of NA activity over a range of drug concentrations. Based on median IC50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influenza B strains. Influenza A viruses with a N1 subtype and influenza B strains both demonstrated a greater sensitivity to zanamivir than to oseltamivir carboxylate, whereas influenza A strains with a N2 subtype were more susceptible to oseltamivir carboxylate. For each of the neuraminidase types, IC50 values for viruses from Australasia and South East Asia were found to be comparable. Based on the data prior to and following the licensing of the drugs into the respective regions, the use of the NA inhibitors did not appear to have a significant impact on the susceptibility of the viruses tested to zanamivir or oseltamivir carboxylate.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Hurt AC,Barr IG,Hartel G,Hampson AW

doi

10.1016/j.antiviral.2003.11.008

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

37-45

issue

1

eissn

0166-3542

issn

1872-9096

pii

S0166354203002961

journal_volume

62

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Interferon-γ influences immunity elicited by vaccines against very virulent Marek's disease virus.

    abstract：:Vaccination of chickens with herpesvirus of turkey (HVT) confers only partial protection against challenge with a very virulent Marek's disease virus (MDV). Here, we evaluated the ability of recombinant chicken interferon-gamma (rChIFN-γ) to enhance protective efficacy of HVT against the very virulent MDV strain, RB1B...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.04.001

    authors： Haq K,Elawadli I,Parvizi P,Mallick AI,Behboudi S,Sharif S

    更新日期：2011-06-01 00:00:00

  • Inhibitory effect of Ephedrae herba, an oriental traditional medicine, on the growth of influenza A/PR/8 virus in MDCK cells.

    abstract：:Using several herbal extracts, we investigated whether certain Kampo medicines exert an inhibitory effect on the acidification of intracellular compartments such as endosomes and lysosomes (referred to as ELS), and thereby inhibit the growth of influenza A virus in Madin-Darby canine kidney cells. The vital fluorescen...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(99)00067-4

    authors： Mantani N,Andoh T,Kawamata H,Terasawa K,Ochiai H

    更新日期：1999-12-31 00:00:00

  • Identification of KX2-391 as an inhibitor of HBV transcription by a recombinant HBV-based screening assay.

    abstract：:Antiviral therapies for chronic hepatitis B virus (HBV) infection that are currently applicable for clinical use are limited to nucleos(t)ide analogs targeting HBV polymerase activity and pegylated interferon alpha (PEG-IFN). Towards establishing an effective therapy for HBV related diseases, it is important to develo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.06.005

    authors： Harada K,Nishitsuji H,Ujino S,Shimotohno K

    更新日期：2017-08-01 00:00:00

  • Mismatched double-stranded RNA (polyI-polyC(12)U) is synergistic with multiple anti-HIV drugs and is active against drug-sensitive and drug-resistant HIV-1 in vitro.

    abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(01)00150-4

    authors： Essey RJ,McDougall BR,Robinson WE Jr

    更新日期：2001-09-01 00:00:00

  • An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.

    abstract：:Epidermal growth factor receptor (EGFr) has been shown to be induced and activated in cells infected with HPV, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. To investigate this possibility, human foreskin tissue was infected with HPV11 and transplant...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.12.004

    authors： Parkinson T,Howett MK,Welsh PA,Patrick SD,Neely EB,Flanagan N,Pollack VA,Pustilnik LR,Moyer J,Perros M

    更新日期：2007-04-01 00:00:00

  • Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance.

    abstract：:Many aspects of the biology and epidemiology of influenza B viruses are far less studied than for influenza A viruses, and one of these aspects is efficacy and resistance to the clinically available antiviral drugs, the neuraminidase (NA) inhibitors (NAIs). Acute respiratory infections are one of the leading causes of...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2013.08.023

    authors： Burnham AJ,Baranovich T,Govorkova EA

    更新日期：2013-11-01 00:00:00

  • C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection.

    abstract：:The TC-83 vaccine strain of Venezuelan equine encephalitis virus (VEEV) causes encephalitis and death in C3H/HeN mice infected by intranasal (i.n.) instillation. Since TC-83 is exempt as a select agent, this mouse model was used in the evaluation of antiviral therapies. Virus titers in the brains of infected mice peak...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2008.01.007

    authors： Julander JG,Skirpstunas R,Siddharthan V,Shafer K,Hoopes JD,Smee DF,Morrey JD

    更新日期：2008-06-01 00:00:00

  • Immunogenicity and protective efficacy of recombinant major envelope protein (rH3L) of buffalopox virus in animal models.

    abstract：:Buffalopox virus, a zoonotic Indian vaccinia-like virus, is responsible for contagious disease affecting mainly buffaloes, cattle and humans. H3L gene, encoding for an immunodominant major envelope protein of intracellular mature virion of orthopoxviruses, is highly conserved and found to elicit neutralizing antibodie...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.12.004

    authors： Kumar A,Yogisharadhya R,Venkatesan G,Bhanuprakash V,Shivachandra SB

    更新日期：2016-02-01 00:00:00

  • Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.

    abstract：:RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.01.021

    authors： Park IH,Kwon YC,Ryu WS,Ahn BY

    更新日期：2014-04-01 00:00:00

  • Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonylmethoxyethyl)adenine (PMEA).

    abstract：:Cats infected with molecularly cloned FeLV-FAIDS develop an immunodeficiency syndrome characterized by persistent antigenemia, decline in circulating CD4+ T lymphocytes, and impaired T-cell-dependent immune responses and opportunistic infection. We evaluated the capacity of PMEA to inhibit the replication of FeLV-FAID...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(91)90060-5

    authors： Hoover EA,Ebner JP,Zeidner NS,Mullins JI

    更新日期：1991-07-01 00:00:00

  • Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

    abstract：:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylami...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90031-2

    authors： Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

    更新日期：1990-09-01 00:00:00

  • Gamma secretase inhibition impairs HCMV replication by reduction of immediate early gene expression at the transcriptional level.

    abstract：:Due to diverse pathogenic potentials, there is a growing need for anti-HCMV agents. In this study, we show that treatment with DAPT, a γ-secretase inhibitor (GSI), impairs HCMV replication as assessed by a progeny assay based on immunostaining. This effect is not limited to DAPT because other GSIs with different struc...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104867

    authors： Lee SM,Han D,Kwon M,Noh H,Lee JH,Yoon Y,Cho JY,Ahn JH,Yoon K

    更新日期：2020-11-01 00:00:00

  • The potential use of influenza virus as an agent for bioterrorism.

    abstract：:Influenza A virus has been responsible for widespread human epidemics because it is readily transmitted from humans to humans by aerosol. Recent events have highlighted the potential of influenza A virus as a bioterrorist weapon: the high virulence of the influenza A virus that infected people in Hong Kong in 1997; an...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/s0166-3542(02)00207-3

    authors： Krug RM

    更新日期：2003-01-01 00:00:00

  • Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets.

    abstract：:Resveratrol (RV), a polyphenolic natural product present in many plants and fruits, exhibits anti-inflammatory, cardio-protective and anti-proliferative properties. Moreover, RV affects a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.09.003

    authors： De Leo A,Arena G,Lacanna E,Oliviero G,Colavita F,Mattia E

    更新日期：2012-11-01 00:00:00

  • Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine.

    abstract：:Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral structural component r...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.09.003

    authors： Noble CG,Li SH,Dong H,Chew SH,Shi PY

    更新日期：2014-11-01 00:00:00

  • The use of sialidase therapy for respiratory viral infections.

    abstract：:DAS181 is an inhaled bacterial sialidase which functions by removing sialic acid (Sia) from the surface of epithelial cells, preventing attachment and subsequent infection by respiratory viruses that utilize Sia as a receptor. DAS181 is typical of bacterial sialidases in cleaving Sia α2-3 and Sia α2-6 linkages, and it...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2013.04.012

    authors： Nicholls JM,Moss RB,Haslam SM

    更新日期：2013-06-01 00:00:00

  • Nanobodies®: new ammunition to battle viruses.

    abstract：:In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is still unclear what the evolutionary advantage of such heavy chain-only a...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2011.09.002

    authors： Vanlandschoot P,Stortelers C,Beirnaert E,Ibañez LI,Schepens B,Depla E,Saelens X

    更新日期：2011-12-01 00:00:00

  • Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the treatment of experimental herpes simplex virus encephalitis in mice.

    abstract：:Systemic treatment of mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) showed a significant therapeutic efficacy against herpes simplex type 1 virus (HSV-1) encephalitis. With treatment initiated 12 h after viral inoculation and continued for 10 consecutive days, BVDU administered intraperitoneally in daily doses...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(83)90010-4

    authors： Park NH,Pavan-Langston D,de Clercq E

    更新日期：1983-03-01 00:00:00

  • The effect of HSV multiplication rate on antiviral drug efficacy in vitro.

    abstract：:HSV-1 multiplication rates have been shown to vary in different tissues and the rate of multiplication may correlate with susceptibility to antiviral chemotherapy. Herpetic stromal keratitis is a necrotizing condition refractive to antiviral therapy and this lack of antiviral efficacy in stromal disease may be the res...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(91)90041-o

    authors： Upadhyay JM,Hill JM,Jemison M,Helmy MF,Kaufman HE

    更新日期：1991-01-01 00:00:00

  • The efficacy of combined therapy of arsenic trioxide and alpha interferon in human T-cell leukemia virus type-1-infected squirrel monkeys (Saimiri sciureus).

    abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) has a poor prognosis owing to its intrinsic resistance to chemotherapy. Although zidovudine (AZT) and alpha interferon (IFN-alpha) give rise to some response and improve the prognosis of ATLL, alternative therapies are nee...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.02.003

    authors： Heraud JM,Mortreux F,Merien F,Contamin H,Mahieux R,Pouliquen JF,Wattel E,Gessain A,de Thé H,Bazarbachi A,Hermine O,Kazanji M

    更新日期：2006-07-01 00:00:00

  • Introduction: Is viral shedding a surrogate marker for transmission of genital herpes?

    abstract：:Genital herpes, caused by either herpes simplex virus type 1 or 2 (HSV-1 and HSV-2), is a significant public health problem worldwide. It increases the risk of infection with HIV, upregulates HIV after infection and can be associated with serious morbidity and mortality. It is now known that clinical and subclinical v...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2004.06.002

    authors： Sacks SL,Griffiths PD,Corey L,Cohen C,Cunningham A,Dusheiko GM,Self S,Spruance S,Stanberry LR,Wald A,Whitley RJ

    更新日期：2004-08-01 00:00:00

  • Perspectives on antiviral drug development.

    abstract：:The 21st International Conference on Antiviral Research provided novel insights and approaches to drug discovery across a wide array of virologic fields. Topics ranged from the chemical synthesis of new compounds against the human immunodeficiency virus (HIV) to the long-term use of established drugs against influenza...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2008.09.003

    authors： Wainberg MA

    更新日期：2009-01-01 00:00:00

  • A DNA vaccine encoding foot-and-mouth disease virus B and T-cell epitopes targeted to class II swine leukocyte antigens protects pigs against viral challenge.

    abstract：:Development of efficient and safer vaccines against foot-and-mouth disease virus (FMDV) is a must. Previous results obtained in our laboratory have demonstrated that DNA vaccines encoding B and T cell epitopes from type C FMDV, efficiently controlled virus replication in mice, while they did not protect against FMDV c...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.07.017

    authors： Borrego B,Argilaguet JM,Pérez-Martín E,Dominguez J,Pérez-Filgueira M,Escribano JM,Sobrino F,Rodriguez F

    更新日期：2011-11-01 00:00:00

  • A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.

    abstract：:The mammarenavirus Lassa (LASV) is highly prevalent in West Africa where it infects several hundred thousand individuals annually resulting in a high number of Lassa fever (LF) cases, a febrile disease associated with high morbidity and significant mortality. Mounting evidence indicates that the worldwide-distributed ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104667

    authors： Cubitt B,Ortiz-Riano E,Cheng BY,Kim YJ,Yeh CD,Chen CZ,Southall NOE,Zheng W,Martinez-Sobrido L,de la Torre JC

    更新日期：2020-01-01 00:00:00

  • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan.

    abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.06.003

    authors： Dapat C,Kondo H,Dapat IC,Baranovich T,Suzuki Y,Shobugawa Y,Saito K,Saito R,Suzuki H

    更新日期：2013-09-01 00:00:00

  • Genetic susceptibility in chronic viral hepatitis.

    abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/s0166-3542(01)00175-9

    authors： Thursz M

    更新日期：2001-11-01 00:00:00

  • Treatment of herpes simplex virus infections.

    abstract：:Herpes simplex virus (HSV) types 1 and 2 are ubiquitous organisms that cause infections in human populations throughout the world. The clinical manifestations of HSV infections are varied, ranging from asymptomatic disease to life-threatening illness in neonates and immunocompromised hosts. This article will review th...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2003.09.006

    authors： Brady RC,Bernstein DI

    更新日期：2004-02-01 00:00:00

  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses.

    abstract：:The creatine kinase/creatine phosphate (CK/CrP) system plays an important role in cellular energy homeostasis. CK isoenzymes, which reversibly generate ATP from CrP, are compartmentalized at cellular sites where energy is produced or utilized. It has been noted that the expression of CK is induced in cells infected by...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(94)90018-3

    authors： Lillie JW,Smee DF,Huffman JH,Hansen LJ,Sidwell RW,Kaddurah-Daouk R

    更新日期：1994-04-01 00:00:00

  • Antiviral activity of natural and synthetic β-carbolines against dengue virus.

    abstract：:Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this work we first evaluated the antiviral activity of natural and synthetic β-carbolines against DENV-2 multiplication in cell cultures. We determined that the natural β-carboline harmol and a synthetic harmine derivative, 9N-methyl...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.08.018

    authors： Quintana VM,Piccini LE,Panozzo Zénere JD,Damonte EB,Ponce MA,Castilla V

    更新日期：2016-10-01 00:00:00

  • Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.

    abstract：:Infections by dengue virus (DENV) are increasing worldwide, with an urgent need for effective anti-DENV agents. We recently identified N-(4-hydroxyphenyl) retinamide (4-HPR), an anti-DENV agent effective against all 4 serotypes of DENV in cell culture, and in a lethal mouse model for DENV infection (Fraser et al., 201...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.03.006

    authors： Fraser JE,Wang C,Chan KW,Vasudevan SG,Jans DA

    更新日期：2016-06-01 00:00:00