Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.

abstract：:Antiviral compounds were evaluated for efficacy against yellow fever virus (YFV) in a hamster model of YFV-induced liver disease. Challenge with a 10(2) 50% cell culture infectious doses of YFV resulted in a 50-80% mortality rate in female hamsters. Virus was detected by quantitative real-time RT-PCR (QRT-PCR) in live...

journal_title：Antiviral research

authors： Julander JG,Morrey JD,Blatt LM,Shafer K,Sidwell RW

更新日期：2007-02-01 00:00:00

abstract：:Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world. Previously, we performed an initial phenotypic screening of 7000 compounds using DENV type 2 (DENV2)-infected BHK-21 cells to identify small molecules which could inhibit virus replicati...

journal_title：Antiviral research

authors： Nobori H,Uemura K,Toba S,Sanaki T,Shishido T,Hall WW,Orba Y,Sawa H,Sato A

更新日期：2020-12-01 00:00:00

abstract：:This study aimed to investigate anti-HBV effect and major active compounds of Su-duxing, a medicine extracted from Chinese herbs. HBV-replicating cell lines HepG2.2.15 (wild-type) and HepG2.A64 (entecavir-resistant) were used for in vitro test. C57BL/6 mice infected by adeno-associated virus carrying 1.3 mer wild-type...

journal_title：Antiviral research

authors： Liu Y,Yao W,Si L,Hou J,Wang J,Xu Z,Li W,Chen J,Li R,Li P,Bo L,Xiao X,Lan J,Xu D

更新日期：2018-07-01 00:00:00

abstract：:Commercial vaccines against human papillomavirus (HPV) have low uptake due to parental autonomy, dosing regimen, cost, and cold chain storage requirements. Carrageenan (CG)-based formulations prevent HPV infection in vitro and in vivo but data are needed on the durability of anti-HPV activity and the effect of seminal...

journal_title：Antiviral research

authors： Rodríguez A,Kleinbeck K,Mizenina O,Kizima L,Levendosky K,Jean-Pierre N,Villegas G,Ford BE,Cooney ML,Teleshova N,Robbiani M,Herold BC,Zydowsky T,Fernández Romero JA

更新日期：2014-08-01 00:00:00

abstract：:Rotavirus (RV) and norovirus (NoV) are the two most important causes of viral gastroenteritis. While vaccine remains an effective prophylactic strategy, development of other approaches, such as passive immunization to control and treat clinical infection and illness of these two pathogens, is necessary. Previously we ...

journal_title：Antiviral research

authors： Dai YC,Zhang XF,Tan M,Huang P,Lei W,Fang H,Zhong W,Jiang X

更新日期：2013-03-01 00:00:00

abstract：:The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-...

journal_title：Antiviral research

authors： Pitts JD,Li PC,de Wispelaere M,Yang PL

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

journal_title：Antiviral research

authors： Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

更新日期：2011-02-01 00:00:00

abstract：:delta 12-Prostaglandin J2 (delta 12-PGJ2), a natural dehydration product of prostaglandin D2 present in human body fluids, was shown to suppress Sendai virus replication in monkey kidney cells, at doses non-toxic to uninfected cells. Dramatic inhibition of virus production could be obtained at doses of delta 12-PGJ2 w...

journal_title：Antiviral research

authors： Amici C,Palamara AT,Garaci E,Santoro MG

更新日期：1992-08-01 00:00:00

abstract：:Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic chori...

journal_title：Antiviral research

authors： Kim YJ,Cubitt B,Chen E,Hull MV,Chatterjee AK,Cai Y,Kuhn JH,de la Torre JC

更新日期：2019-09-01 00:00:00

abstract：:Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...

journal_title：Antiviral research

authors： Gantlett KE,Weber JN,Sattentau QJ

更新日期：2007-09-01 00:00:00

abstract：:We established a sensitive and accurate method for screening of anti-adenovirus agents using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. MKN-28 cells, which are well-differentiated stomach adenocarcinoma cells, were used for adenovirus (ADV) infection and examined for the anti-ADV act...

journal_title：Antiviral research

authors： Kodama E,Shigeta S,Suzuki T,De Clercq E

更新日期：1996-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the stable genomic form as the template for viral transcription, plays a crucial role in viral persistence which remains a major global health problem. While accumulating evidence suggests the involvement of transcription factors and epigenetic machinery...

journal_title：Antiviral research

authors： Xu L,Wu Z,Tan S,Wang Z,Lin Q,Li X,Song X,Liu Y,Song Y,Zhang J,Peng J,Gao L,Gong Y,Liang X,Zuo X,Ma C

更新日期：2018-05-01 00:00:00

abstract：:Murine cytomegalovirus (MCMV) neither induces a viral thymidine kinase (TK) nor enhances the activity of a cellular TK. Nevertheless, MCMV is highly susceptible to 9-(2-hydroxyethoxymethyl)guanine (acyclovir, ACV). The cellular TK is neither responsible for phosphorylation of ACV nor its anti-MCMV activity. This is cl...

journal_title：Antiviral research

authors： Ochiai H,Kumura K,Minamishima Y

更新日期：1992-01-01 00:00:00

abstract：:Avian influenza A(H6N1) virus is one of the most common viruses isolated from migrating birds and domestic poultry in many countries. The first and only known case of human infection by H6N1 virus in the world was reported in Taiwan in 2013. This led to concern that H6N1 virus may cause a threat to public health. In t...

journal_title：Antiviral research

authors： Yang JR,Chen CY,Kuo CY,Cheng CY,Lee MS,Cheng MC,Yang YC,Wu CY,Wu HS,Liu MT,Hsiao PW

更新日期：2016-02-01 00:00:00

abstract：:Serious outbreaks of severe acute respiratory syndrome (SARS), caused by the newly discovered coronavirus SARS-CoV, occurred between late 2002 and early 2003 and there is an urgent need for effective antiviral agents. RNA interference in animals and post-transcriptional gene silencing plants is mediated by small doubl...

journal_title：Antiviral research

authors： Wu CJ,Huang HW,Liu CY,Hong CF,Chan YL

更新日期：2005-01-01 00:00:00

abstract：:Nalidixic acid and oxolinic acid, two antibacterial agents known to inhibit bacterial DNA gyrase, are shown to suppress the replication, as well as the cytopathic effect, of BK virus in Vero cell cultures. The inhibition of virus replication was detectable at day 4 post infection in cultures which had been continuousl...

journal_title：Antiviral research

authors： Portolani M,Pietrosemoli P,Cermelli C,Mannini-Palenzona A,Grossi MP,Paolini L,Barbanti-Brodano G

更新日期：1988-04-01 00:00:00

abstract：:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylami...

journal_title：Antiviral research

authors： Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

更新日期：1990-09-01 00:00:00

abstract：:A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the che...

journal_title：Antiviral research

authors： Inouye Y,Tokutake Y,Yoshida T,Seto Y,Hujita H,Dan K,Yamamoto A,Nishiya S,Yamase T,Nakamura S

更新日期：1993-04-01 00:00:00

abstract：:In the event of a bioterror attack with variola virus (smallpox), exposure may only be identified following onset of fever. To determine if antiviral therapy with brincidofovir (BCV; CMX001) initiated at, or following, onset of fever could prevent severe illness and death, a lethal rabbitpox model was used. BCV is in ...

journal_title：Antiviral research

authors： Grossi IM,Foster SA,Gainey MR,Krile RT,Dunn JA,Brundage T,Khouri JM

更新日期：2017-07-01 00:00:00

abstract：:Introduction of segmented genomes into virion is an important process in viral replication of rotavirus. We previously studied the assortment of the VP7 gene segment (encoding outer capsid protein VP7) in the genetic background of simian rotavirus SA11 (G serotype 3, G3) and found the preferential selection of homolog...

journal_title：Antiviral research

authors： Okada J,Kobayashi N,Taniguchi K,Urasawa S

更新日期：1998-04-01 00:00:00

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guilla...

journal_title：Antiviral research

authors： Albulescu IC,Kovacikova K,Tas A,Snijder EJ,van Hemert MJ

更新日期：2017-07-01 00:00:00

abstract：:Site-directed in vitro mutagenesis was used to create analogs of human interferons (IFNs)-alpha 1 and -alpha 4. Analogs were expressed in vitro using SP6 RNA polymerase and a rabbit reticulocyte lysate cell-free protein synthesis system. Amino acid substitutions for the highly conserved residues at positions 33, 121, ...

journal_title：Antiviral research

authors： Tymms MJ,McInnes B,Waine GJ,Cheetham BF,Linnane AW

更新日期：1989-08-01 00:00:00

abstract：:A newly synthesized imide derivative of 3-nitro-1,8-naphthalic acid, 5-amino-2-(2-dimethylaminoethyl)benzo-[de]-isoquinolin-1,3-dione (designated M-FA-142), was tested on chick embryo cells against herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), and on Vero cells against African swine fever virus (ASFV). ...

journal_title：Antiviral research

authors： García Gancedo A,Gil-Fernández C,Vilas P,Pérez S,Rodriguez F,Paez E,Braña MF,Roldán CM

更新日期：1984-08-01 00:00:00

abstract：:The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...

journal_title：Antiviral research

authors： Alotte C,Martin A,Caldarelli SA,Di Giorgio A,Condom R,Zoulim F,Durantel D,Hantz O

更新日期：2008-12-01 00:00:00

abstract：:The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of...

journal_title：Antiviral research

authors： Andrei G,Carter K,Janeba Z,Sampath A,Schang LM,Tarbet EB,Vere Hodge RA,Bray M,Esté JA

更新日期：2017-09-01 00:00:00

abstract：:The era of antiviral chemotherapy started more than 50 years with the findings by Domagk and his colleagues that thiosemicarbazones showed activity against vaccinia virus. One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. With the successful implementation of the smallpox vacci...

journal_title：Antiviral research

authors： Neyts J,De Clercq E

更新日期：2003-01-01 00:00:00

abstract：:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2...

journal_title：Antiviral research

authors： Verheyden B,Andries K,Rombaut B

更新日期：2004-03-01 00:00:00

abstract：:Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV infections. Alpha interferons in particular have found a place in th...

journal_title：Antiviral research

authors： Gangemi JD,Pirisi L,Angell M,Kreider JW

更新日期：1994-07-01 00:00:00

abstract：:Although in vitro studies have been performed to dissect the mechanism of action of IFNα, detailed in vivo studies on the long-term effects of IFNα on monocytes have not been performed. Here we examined peripheral blood from 14 chronic HCV patients at baseline and 12 weeks after start of IFNα-based therapy. Monocytes ...

journal_title：Antiviral research

authors： Hou J,Groothuismink ZM,Koning L,Roomer R,van IJcken WF,Kreefft K,Liu BS,Janssen HL,de Knegt RJ,Boonstra A

更新日期：2014-09-01 00:00:00

abstract：:SAMHD1 is a triphosphohydrolase that restricts HIV-1 by limiting the intracellular dNTP pool required for reverse transcription. Although SAMHD1 is expressed and active/unphosphorylated in most cell lines, its restriction activity is thought to be relevant only in non-cycling cells. However, an in depth evaluation of ...

journal_title：Antiviral research

authors： Badia R,Pujantell M,Torres-Torronteras J,Menéndez-Arias L,Martí R,Ruzo A,Pauls E,Clotet B,Ballana E,Esté JA,Riveira-Muñoz E

更新日期：2017-06-01 00:00:00