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HPV replication in experimental models: effects of interferon.

Abstract：

:Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV infections. Alpha interferons in particular have found a place in the treatment of anogenital disease, plantar warts, and laryngeal papillomas. While their is significant clinical evidence to suggest that interferon is useful in therapy of disease, the cellular mechanism(s) (i.e., antiviral, antiproliferative, immunomodulatory) by which IFN is able to control HPV-induced pathology is not well understood. This review focuses on experimental animal and cell culture models which are currently being used to help identify the antiviral, antiproliferative and immunomodulatory effects of IFN on HPV infection.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Gangemi JD,Pirisi L,Angell M,Kreider JW

doi

10.1016/0166-3542(94)90066-3

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

175-90

issue

2-3

eissn

0166-3542

issn

1872-9096

pii

0166-3542(94)90066-3

journal_volume

24

pub_type

杂志文章,评审

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