In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir).

abstract：:Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and ...

journal_title：Antiviral research

authors： Tong W,Zheng H,Li GX,Gao F,Shan TL,Zhou YJ,Yu H,Jiang YF,Yu LX,Li LW,Kong N,Tong GZ,Li JC

更新日期：2020-01-01 00:00:00

abstract：:Human papilloma virus (HPV)-16 is the prevalent genotype associated with cervical tumours. Virus-like-particle (VLP)-based vaccines have proven to be effective in limiting new infections of high-risk HPVs, but their high cost has hampered their use, especially in the poor developing countries. Avipox-based recombinant...

journal_title：Antiviral research

authors： Bissa M,Zanotto C,Pacchioni S,Volonté L,Venuti A,Lembo D,De Giuli Morghen C,Radaelli A

更新日期：2015-04-01 00:00:00

abstract：:Coxsackievirus A16 (CA16) is one of the main causative agents of hand, foot and mouth disease (HFMD), which is a common infectious disease in children. CA16 infection may lead to severe nervous system damage and even death in humans. However, study of the pathogenesis of CA16 infection and development of vaccines and ...

journal_title：Antiviral research

authors： Liu Q,Shi J,Huang X,Liu F,Cai Y,Lan K,Huang Z

更新日期：2014-05-01 00:00:00

abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

journal_title：Antiviral research

authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

更新日期：2021-01-07 00:00:00

abstract：:There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infect...

journal_title：Antiviral research

authors： Laufer N,Abusamra L,Bolcic F,Gun A,Rolón MJ,Pérez H,Krolewiecki A,Salomón H,Quarleri J,Cahn P

更新日期：2011-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, invariably fatal neurologic disorder resulting from upper and lower motor neuron degeneration, which typically develops during the sixth or seventh decade of life, and is diagnosed based on standard clinical criteria. Its underlying cause remains undetermined. The ...

journal_title：Antiviral research

authors： Alfahad T,Nath A

更新日期：2013-08-01 00:00:00

abstract：:The 21st International Conference on Antiviral Research provided novel insights and approaches to drug discovery across a wide array of virologic fields. Topics ranged from the chemical synthesis of new compounds against the human immunodeficiency virus (HIV) to the long-term use of established drugs against influenza...

journal_title：Antiviral research

authors： Wainberg MA

更新日期：2009-01-01 00:00:00

abstract：:The effect of interferon on the replication of herpes simplex virus types 1 and 2 was studied in two murine macrophage-like cell lines which differ in their ability to synthesize interferon. Higher titers of herpes simplex virus type 1 occurred in PU5-1.8 cell cultures where interferon was not produced than in J774A.1...

journal_title：Antiviral research

authors： Salo RJ,Ortega AP

更新日期：1986-05-01 00:00:00

abstract：:The K70E mutation in HIV-1 reverse transcriptase was observed in 10% of virologic non-responders of the abacavir/lamivudine/tenofovir arm of ESS30009, alone, or in mixtures with K65R by population sequencing. Clonal analysis of six ESS30009 K70E isolates failed to identify double mutants carrying K65R+K70E. Site-direc...

journal_title：Antiviral research

authors： Kagan RM,Lee TS,Ross L,Lloyd RM Jr,Lewinski MA,Potts SJ

更新日期：2007-09-01 00:00:00

abstract：:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2...

journal_title：Antiviral research

authors： Verheyden B,Andries K,Rombaut B

更新日期：2004-03-01 00:00:00

abstract：:The hepatitis B virus nucleocapsid or core antigen is extremely immunogenic during infection and after immunization. This review summarizes several features of the nucleocapsid which explain this exceptionally high immunogenicity: a unique three-dimensional folding, the presence of a region that interacts with immunog...

journal_title：Antiviral research

authors： Vanlandschoot P,Cao T,Leroux-Roels G

更新日期：2003-10-01 00:00:00

abstract：:Argentine hemorrhagic fever is a systemic viral disease caused by Junin virus, with a mortality of 15-30% in untreated individuals. Current specific therapy is highly effective in reducing mortality, and consists of the early administration of immune plasma in defined doses of specific neutralizing antibodies per kg o...

journal_title：Antiviral research

authors： Enria DA,Maiztegui JI

更新日期：1994-01-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:Conventional treatment of severe viral disease is limited by the narrow choice as well as the often-significant side effects or lack of clear efficacy of antiviral chemotherapy. At the same time, however, it is known that a reduction in viral load leads to significant clinical improvement in a number of important vira...

journal_title：Antiviral research

authors： Oberender F,Oberender H,Altrichter J,Reisinger EC,Mitzner SR

更新日期：2010-08-01 00:00:00

abstract：:Respiratory syncytial virus (RSV), which presents the primary cause of bronchiolitis and pneumonia among infants and causes significant morbidity and mortality in immunodeficient patients, remains a health problem worldwide. Unfortunately, an effective vaccine is currently unavailable and pharmacologic treatment needs...

journal_title：Antiviral research

authors： Xie YY,Zhao XD,Jiang LP,Liu HL,Wang LJ,Fang P,Shen KL,Xie ZD,Wu YP,Yang XQ

更新日期：2006-08-01 00:00:00

abstract：:JNJ63623872 (formerly known as VX-787) is an inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. This interaction blocks the cap-snatching activity of the virus that is essential for virus replication. Previously published work has documented antiviral activity of JNJ63623872 in ...

journal_title：Antiviral research

authors： Smee DF,Barnard DL,Jones SM

更新日期：2016-12-01 00:00:00

abstract：:Cytomegalovirus (CMV) is one of the most common opportunistic infections after transplantation. To prevent CMV infections, universal prophylaxis and pre-emptive therapy with ganciclovir or its prodrug valganciclovir is applied. However, prolonged antiviral therapy may result in drug-resistance emergence. We describe a...

journal_title：Antiviral research

authors： Andrei G,Van Loon E,Lerut E,Victoor J,Meijers B,Bammens B,Sprangers B,Gillemot S,Fiten P,Opdenakker G,Lagrou K,Kuypers D,Snoeck R,Naesens M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

journal_title：Antiviral research

authors： Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

更新日期：2011-02-01 00:00:00

abstract：:We studied the effects of two antiviral agents, human interferon-alpha (IFN-alpha) and ribavirin, on subacute sclerosing panencephalitis (SSPE) virus infections in hamsters. By intracranial administration, IFN-alpha alone improved the survival of infected hamsters by 20% at a dose of 6 x 10(4) IU/kg every other day fo...

journal_title：Antiviral research

authors： Takahashi T,Hosoya M,Kimura K,Ohno K,Mori S,Takahashi K,Shigeta S

更新日期：1998-01-01 00:00:00

abstract：:Venezuelan equine encephalitis virus (VEEV) may cause encephalitis in humans, for which no FDA-approved antiviral treatment is available. Carbocyclic cytosine (carbodine) has broad-spectrum activity but toxicity has limited its utility. It was anticipated that one of the enantiomers of carbodine would show enhanced ac...

journal_title：Antiviral research

authors： Julander JG,Bowen RA,Rao JR,Day C,Shafer K,Smee DF,Morrey JD,Chu CK

更新日期：2008-12-01 00:00:00

abstract：:Itraconazole (ITZ) is a well-known, FDA-approved antifungal drug that is also in clinical trials for its anticancer activity. ITZ exerts its anticancer activity through several disparate targets and pathways. ITZ inhibits angiogenesis by hampering the functioning of the vascular endothelial growth receptor 2 (VEGFR2) ...

journal_title：Antiviral research

authors： Bauer L,Ferla S,Head SA,Bhat S,Pasunooti KK,Shi WQ,Albulescu L,Liu JO,Brancale A,van Kuppeveld FJM,Strating JRPM

更新日期：2018-08-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00

abstract：:Human adenoviruses (HAdVs) usually cause mild respiratory infections, but they can also lead to fatal outcomes for immunosuppressive patients. Unfortunately, there has been no specific anti-HAdV drug approved for medical use. A better understanding of the nature of virus-host interactions during infection is beneficia...

journal_title：Antiviral research

authors： Wang X,Zhang Q,Zhou Z,Liu M,Chen Y,Li J,Xu L,Guo J,Li Q,Yang J,Wang S

更新日期：2018-04-01 00:00:00

abstract：:Genital herpes, caused by either herpes simplex virus type 1 or 2 (HSV-1 and HSV-2), is a significant public health problem worldwide. It increases the risk of infection with HIV, upregulates HIV after infection and can be associated with serious morbidity and mortality. It is now known that clinical and subclinical v...

journal_title：Antiviral research

authors： Sacks SL,Griffiths PD,Corey L,Cohen C,Cunningham A,Dusheiko GM,Self S,Spruance S,Stanberry LR,Wald A,Whitley RJ

更新日期：2004-08-01 00:00:00

abstract：:Phosphorothioate-modified oligomers have been shown to be more stable than natural oligomers to serum and cellular nucleases. For this reason we used these analogs to explore the utility of antisense molecules as potential antiviral agents. The oligomers we studied are complementary to the initiation region of the Vmw...

journal_title：Antiviral research

authors： Kmetz ME,Ceruzzi M,Schwartz J

更新日期：1991-09-01 00:00:00

abstract：:Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and antiretrovirals is critical. Here, we u...

journal_title：Antiviral research

authors： Daly MB,Sterling M,Holder A,Dinh C,Nishiura K,Khalil G,García-Lerma JG,Dobard C

更新日期：2020-12-29 00:00:00

abstract：:Serum from wild alligators was collected and tested for antibiotic activity against three enveloped viruses using cell-based assays. Alligator serum demonstrated antiviral activities against human immunodeficiency virus type 1 (HIV-1; IC50=0.9%), West Nile virus (WNV; IC50=4.3%), and Herpes simplex virus type 1 (HSV-1...

journal_title：Antiviral research

authors： Merchant ME,Pallansch M,Paulman RL,Wells JB,Nalca A,Ptak R

更新日期：2005-04-01 00:00:00

abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...

journal_title：Antiviral research

authors： Jiang Y,Liu S,Shen S,Guo H,Huang H,Wei W

更新日期：2020-04-01 00:00:00

abstract：:As part of our studies on the molecular basis for the antiherpes activity of 5'-AdThd (5'-amino-5'-deoxythymidine), a study of the HSV-1 DNA synthesized in infected Vero cells exposed to 5'-AdThd was undertaken. Unlike many other antiviral nucleoside analogs, 5'-AdThd did not inhibit HSV-1 DNA synthesis. Analysis of t...

journal_title：Antiviral research

authors： Otto MJ,Prusoff WH

更新日期：1984-10-01 00:00:00

abstract：:A new adamantane derivative N,N'-bis (ethylene)P(1-adamantyl)-phosphonis diamide, was found to inhibit Rous sarcoma virus replication in much the same manner as reported for the parent compound, 1-adamantanamine hydrochloride. ...

journal_title：Antiviral research

authors： McGraw TL,Cates LA,Daley LS,Chen YC

更新日期：1981-11-01 00:00:00