Abstract：
:Phosphorothioate-modified oligomers have been shown to be more stable than natural oligomers to serum and cellular nucleases. For this reason we used these analogs to explore the utility of antisense molecules as potential antiviral agents. The oligomers we studied are complementary to the initiation region of the Vmw65 (alpha-TIF) gene of HSV-1 which is important both for its structural role and in the transactivation of the alpha genes of HSV. Our results demonstrate that Vmw65-specific oligomers inhibit HSV KOS replication in a dose-dependent manner from 25 micrograms/ml (4.3 microM) to 50 ng/ml (9 nM). Vmw65 protein synthesis is inhibited from 51 to 68% at 5 micrograms/ml (0.8 microM) using Vmw65-specific oligomers 293s and 432s respectively. A random AT-rich oligomer, 007s, inhibited HSV KOS replication in a non-dose-dependent manner. Inhibition was only observed at a concentration of 12.5 micrograms/ml (2.1 microM) or more, using an MOI (multiplicity of infection) of 0.05 PFU/cell and a 24-h post-infection harvest.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Kmetz ME,Ceruzzi M,Schwartz Jdoi
10.1016/0166-3542(91)90023-ksubject
Has Abstractpub_date
1991-09-01 00:00:00pages
173-84issue
2eissn
0166-3542issn
1872-9096pii
0166-3542(91)90023-Kjournal_volume
16pub_type
杂志文章abstract：:We have characterized the differential actions of acyclovir and penciclovir against varicella-zoster virus (VZV) in cell culture by comparing the frequency of appearance of resistant viruses followed by their characterization. Cells were infected with cell-free virus and the cultures were successively treated with inc...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(98)00057-6
更新日期：1999-01-01 00:00:00
abstract：:We have previously reported a new class of dendrimers with tryptophan (Trp) residues on the surface that show dual antiviral activities against HIV and enterovirus EV71. The prototype compound of this family is a derivative of pentaerythritol with 12 peripheral Trp groups and trivalent spacer arms. Here a novel series...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.06.006
更新日期：2019-08-01 00:00:00
abstract：:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.104650
更新日期：2020-01-01 00:00:00
abstract：:Sixteen herpes simplex virus type 1 (HSV-1) and four type 2 (HSV-2) isolates resistant to acyclovir (ACV) were characterized retrospectively for drug resistance. Phenotypic testing was performed by means of tetrazolium reduction assay and genotypic analysis was carried out by sequencing of thymidine kinase (TK) and DN...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2010.03.002
更新日期：2010-06-01 00:00:00
abstract：:The era of antiviral chemotherapy started more than 50 years with the findings by Domagk and his colleagues that thiosemicarbazones showed activity against vaccinia virus. One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. With the successful implementation of the smallpox vacci...
journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/s0166-3542(02)00197-3
更新日期：2003-01-01 00:00:00
abstract：:Lactoferrin (LF) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to LF. One of the functions of LF is the transport of metals, but LF is also an important component of the non-specific immune system, since LF has antimicrobial properties again...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/s0166-3542(01)00195-4
更新日期：2001-12-01 00:00:00
abstract：:In the absence of antiviral treatment, chronic hepatitis C virus (HCV) infection is a liver disease characterized by the development of necroinflammatory changes and progressive liver fibrosis, leading to cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). The approval of ribavirin in combination th...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2003.08.009
更新日期：2003-10-01 00:00:00
abstract：:T Follicular helper cells (TFH) are considered critical for B cell antibody response, and recent efforts have focused on promoting TFH in order to enhance vaccine efficacy. We studied the frequency and function of TFH in nasopharynx-associated lymphoid tissues (NALT) from children and adults, and its role in anti-infl...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.05.021
更新日期：2016-08-01 00:00:00
abstract：:Influenza viruses are major respiratory pathogens responsible for both seasonal epidemics and occasional pandemics worldwide. The current available treatment options have limited efficacy and thus the development of new antivirals is highly needed. We previously reported the identification of a series of cycloheptathi...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.03.003
更新日期：2019-05-01 00:00:00
abstract：:There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infect...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2011.10.006
更新日期：2011-12-01 00:00:00
abstract：:A synthetic muramyldipeptide (MDP) and two analogues, B30-MDP and MDP-Lys(L18), augmented serum interferon (IFN) production in mice by the inducers lipopolysaccharide (LPS) and polyinosinic acid:polycytidylic acid (poly I:C), and also augmented immune IFN production induced by purified protein derivative (PPD) in myco...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(85)90004-x
更新日期：1985-12-01 00:00:00
abstract：:Several arenaviruses cause hemorrhagic fever (HF) in humans, and evidence indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance. Moreover, arenaviruses pose a biodefense threat. No licensed anti-arenavirus vaccine...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2008.08.002
更新日期：2008-12-01 00:00:00
abstract：:Nalidixic acid and oxolinic acid, two antibacterial agents known to inhibit bacterial DNA gyrase, are shown to suppress the replication, as well as the cytopathic effect, of BK virus in Vero cell cultures. The inhibition of virus replication was detectable at day 4 post infection in cultures which had been continuousl...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(88)90004-6
更新日期：1988-04-01 00:00:00
abstract：:Commercial vaccines against human papillomavirus (HPV) have low uptake due to parental autonomy, dosing regimen, cost, and cold chain storage requirements. Carrageenan (CG)-based formulations prevent HPV infection in vitro and in vivo but data are needed on the durability of anti-HPV activity and the effect of seminal...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2014.05.018
更新日期：2014-08-01 00:00:00
abstract：:The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(96)00990-4
更新日期：1996-12-01 00:00:00
abstract：:HIV-1 integrase (IN) is one of three essential enzymes (along with reverse transcriptase and protease) encoded by the viral pol gene. IN mediates two critical reactions during viral replication; firstly 3'-end processing (3'EP) of the double-stranded viral DNA ends and then strand transfer (STF) which joins the viral ...
journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.antiviral.2009.11.004
更新日期：2010-01-01 00:00:00
abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00002-5
更新日期：2002-06-01 00:00:00
abstract：:Desferrioxamine (DFO) is commonly used in therapy as a chelator of ferric ion in disorders of iron overload. We found that DFO inhibits human cytomegalovirus (HCMV) replication in infected cultures of human foreskin fibroblasts (HFF) at concentrations that have been achieved in humans with no significant adverse effec...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(94)90095-7
更新日期：1994-09-01 00:00:00
abstract：:The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels of anti-H1N1 antibodies at day30 after vaccination, higher reactivity was observed in AV at day180. While AV indu...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2017.05.009
更新日期：2017-08-01 00:00:00
abstract：:An extract of the cactus plant Opuntia streptacantha inhibited intracellular virus replication and inactivated extracellular virus. Inhibition of virus replication also occurred following pre-infection treatment--a favourable finding in terms of in-vivo limitation of virus disease. There was inhibition of both DNA and...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(95)00839-x
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:By modulating the antiviral immune response via vitamin D receptor, the active form of vitamin D (1,25-dihydroxyvitamin D, calcitriol) could play a central role in protection against respiratory virus infections. This in vitro study tested the hypothesis that respiratory viruses modulate vitamin D receptor e...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:Enterovirus-71 (EV71) is one of the major causative reagents for hand-foot-and-mouth disease. In particular, EV71 causes severe central nervous system infections and leads to numerous dead cases. Although several inactivated whole-virus vaccines have entered in clinical trials, no antiviral agent has been provided for...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.12.008
更新日期：2014-03-01 00:00:00
abstract：:The effects of caps, dinucleotides, oligonucleotides and polynucleotides on influenza virus RNA polymerase activity have been investigated. The results show that both methyl groups in a cap are necessary for optimal stimulation of polymerase activity. Both m7G(5')ppp(5')Am and ApG stimulated the influenza RNA polymera...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(81)90036-x
更新日期：1981-06-01 00:00:00
abstract：:The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppresse...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(95)00955-8
更新日期：1996-08-01 00:00:00
abstract：:Wedelolactone (WDL) is a coumestan present in the plants Eclipta prostrata and Wedelia calendulacea which are used for treatment of a multitude of health problems in traditional medicine. It has previously been shown that WDL exerts antiviral activity against human immunodeficiency virus and hepatitis C virus. In this...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.104677
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Herpes zoster (HZ) risk is high in renal transplant recipients. Vaccination prior to transplantation may provide a useful strategy for the prevention of HZ in the posttranplantation period. However, it is not known whether immunity to varicella-zoster virus (VZV) is affected due to treatment surrounding tran...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104938
更新日期：2020-11-01 00:00:00
abstract：:Although canine rabies has been eliminated from industrialized countries, infected dogs remain the primary source of human and livestock exposures in Asia, Africa and much of South America. Human deaths are the most important direct economic impact of canine rabies, followed by livestock losses and the cost of PEP, wh...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2013.03.004
更新日期：2013-05-01 00:00:00
abstract：:Interferon alpha-2b (IFN) alone or in combination with Ribavirin is approved in the United States for the treatment of chronic hepatitis C virus (HCV) infection. We have previously reported that the glucosidase inhibitor, n-butyl deoxynojirimycin (nB-DNJ) inhibits the production of infectious bovine diarrhea virus (BV...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00075-x
更新日期：2002-09-01 00:00:00
abstract：:Human cytomegalovirus terminase complex cleaves the concatemeric genomic viral DNA into unit lengths during genome packaging and particle assembly. Terminase complex ATPase and endonuclease activity is provided by the viral protein pUL89. pUL89 is an attractive drug target because its activities are required for infec...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2018.01.015
更新日期：2018-04-01 00:00:00
abstract：:Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2017.05.007
更新日期：2017-08-01 00:00:00
