The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.

abstract：:Previous studies have demonstrated that cyclopentenone prostaglandins (cyPGs) inhibit the replication of a wide variety of DNA and RNA viruses in different mammalian cell types. We investigated a new role for prostaglandin A1 (PGA1) in the inhibition of hepatitis C virus (HCV)-IRES-mediated translation. PGA1 exhibited...

journal_title：Antiviral research

authors： Tsukimoto A,Sugiyama R,Abe M,Nishitsuji H,Shimizu Y,Shimotohno K,Kawai G,Takaku H

更新日期：2015-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic hepatitis and end-stage liver diseases. Mature HCV virions are bound by host-derived lipoproteins. Lack of an HCV vaccine warrants a major role of antiviral treatment in the global elimination of hepatitis C. Although direct-acting antivirals (DAAs) are replacing t...

journal_title：Antiviral research

authors： Li X,Li J,Feng Y,Cai H,Li YP,Peng T

更新日期：2020-05-01 00:00:00

abstract：:The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transf...

journal_title：Antiviral research

authors： Yang WT,Yang GL,Wang Q,Huang HB,Jiang YL,Shi CW,Wang JZ,Huang KY,Jin YB,Wang CF

更新日期：2017-02-01 00:00:00

abstract：:Due to diverse pathogenic potentials, there is a growing need for anti-HCMV agents. In this study, we show that treatment with DAPT, a γ-secretase inhibitor (GSI), impairs HCMV replication as assessed by a progeny assay based on immunostaining. This effect is not limited to DAPT because other GSIs with different struc...

journal_title：Antiviral research

authors： Lee SM,Han D,Kwon M,Noh H,Lee JH,Yoon Y,Cho JY,Ahn JH,Yoon K

更新日期：2020-11-01 00:00:00

abstract：:A synthetic muramyldipeptide (MDP) and two analogues, B30-MDP and MDP-Lys(L18), augmented serum interferon (IFN) production in mice by the inducers lipopolysaccharide (LPS) and polyinosinic acid:polycytidylic acid (poly I:C), and also augmented immune IFN production induced by purified protein derivative (PPD) in myco...

journal_title：Antiviral research

authors： Ikeda S,Matsuda Y,Nishimura C

更新日期：1985-12-01 00:00:00

abstract：:Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV infections. Alpha interferons in particular have found a place in th...

journal_title：Antiviral research

authors： Gangemi JD,Pirisi L,Angell M,Kreider JW

更新日期：1994-07-01 00:00:00

abstract：:Studying the biogenesis of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and developing anti-HBV agents require analytical methods to quantify viral DNA levels inside host cells. The well-accepted Southern blotting method is only semi-quantitative, while the other widely used methods (based on qPCR) ...

journal_title：Antiviral research

authors： Gao Z,Yan L,Li W

更新日期：2019-08-01 00:00:00

abstract：:Interleukin (IL)28-B polymorphism has been related to interferon response in the treatment of hepatitis C, but its role in chronic hepatitis B (CHB) therapy is still poorly understood. We aimed to investigate the effect of IL28-B polymorphisms in the treatment with pegylated-interferon (PEG-IFN) of patients with CHB. ...

journal_title：Antiviral research

authors： Boglione L,Cusato J,Allegra S,Esposito I,Patti F,Cariti G,Di Perri G,D'Avolio A

更新日期：2014-02-01 00:00:00

abstract：:The reverse transcriptase (RT) of HIV which has been inhibited by the incorporation of AZT into the primer strand is subject to a deblocking reaction by cellular ATP. This reaction yields unblocked primer plus the dinucleoside tetraphosphate, AZTp(4)A. In the present study, we report that AZTp(4)A is an excellent subs...

journal_title：Antiviral research

authors： Pitcher WH 3rd,Kirby TW,DeRose EF,London RE

更新日期：2003-05-01 00:00:00

abstract：:For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...

journal_title：Antiviral research

authors： Peterson SE,Wang S,Ranheim T,Owen KE

更新日期：2006-02-01 00:00:00

abstract：:3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The...

journal_title：Antiviral research

authors： Vrang L,Bazin H,Remaud G,Chattopadhyaya J,Oberg B

更新日期：1987-03-01 00:00:00

abstract：:In vitro studies of HBV core promoter mutations in hepatoma cell lines suggest that some mutations in core promoter transcription factor binding sites result in reduced core promoter activity and viral replication. We sought to validate this hypothesis using clinical samples with viral load differences before and afte...

journal_title：Antiviral research

authors： Cheng Y,Seet BL,Ong CS,Wasser S,Tan TM,Peter FJ,Lim SG

更新日期：2006-03-01 00:00:00

abstract：:Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...

journal_title：Antiviral research

authors： Gantlett KE,Weber JN,Sattentau QJ

更新日期：2007-09-01 00:00:00

abstract：:Oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are potent stimulators of the innate immune system, and are capable of aborting several infections in a non-specific manner. We here report studies of the capacity of such ODN to protect mice against infection with foot and mouth disease virus (FMDV). Susc...

journal_title：Antiviral research

authors： Kamstrup S,Frimann TH,Barfoed AM

更新日期：2006-10-01 00:00:00

abstract：:The latent reservoir of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs ...

journal_title：Antiviral research

authors： Yang H,Li X,Yang X,Lu P,Wang Y,Jiang Z,Pan H,Zhao L,Zhu Y,Khan IU,Shen Y,Lu H,Zhang T,Jiang G,Ma Z,Wu H,Zhu H

更新日期：2019-09-01 00:00:00

abstract：:Antiviral compounds were evaluated for efficacy against yellow fever virus (YFV) in a hamster model of YFV-induced liver disease. Challenge with a 10(2) 50% cell culture infectious doses of YFV resulted in a 50-80% mortality rate in female hamsters. Virus was detected by quantitative real-time RT-PCR (QRT-PCR) in live...

journal_title：Antiviral research

authors： Julander JG,Morrey JD,Blatt LM,Shafer K,Sidwell RW

更新日期：2007-02-01 00:00:00

abstract：:Lack of vaccines and efficient control measures complicate the control and eradication of African swine fever (ASF). Limitations of conventional inactivated and attenuated virus-based vaccines against African swine fever virus (ASFV) highlight the need to use new technologies to develop efficient and safe vaccines aga...

journal_title：Antiviral research

authors： Argilaguet JM,Pérez-Martín E,López S,Goethe M,Escribano JM,Giesow K,Keil GM,Rodríguez F

更新日期：2013-04-01 00:00:00

abstract：:The EIAV (equine infectious anemia virus) multi-species attenuated vaccine EIAV(DLV121) successfully prevented the spread of equine infectious anemia (EIA) in China in the 1970s and provided an excellent model for the study of protective immunity to lentiviruses. In this study, we compared immune responses induced by ...

journal_title：Antiviral research

authors： Lin YZ,Shen RX,Zhu ZY,Deng XL,Cao XZ,Wang XF,Ma J,Jiang CG,Zhao LP,Lv XL,Shao YM,Zhou JH

更新日期：2011-11-01 00:00:00

abstract：:The effect of interferon on the replication of herpes simplex virus types 1 and 2 was studied in two murine macrophage-like cell lines which differ in their ability to synthesize interferon. Higher titers of herpes simplex virus type 1 occurred in PU5-1.8 cell cultures where interferon was not produced than in J774A.1...

journal_title：Antiviral research

authors： Salo RJ,Ortega AP

更新日期：1986-05-01 00:00:00

abstract：:In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB...

journal_title：Antiviral research

authors： Giannecchini S,Wise HM,Digard P,Clausi V,Del Poggetto E,Vesco L,Puzelli S,Donatelli I,Azzi A

更新日期：2011-10-01 00:00:00

abstract：:As has been established in rabbits, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) is superior to 5-iodo-2'-deoxyuridine (IDU) in the topical treatment of epithelial HSV-1 (herpes simplex virus type 1) keratitis, and superior to 5-trifluoromethyl-2'-deoxyuridine (TFT) in the topical treatment of deep stromal HSV-1 kerati...

journal_title：Antiviral research

authors： Maudgal PC,De Clercq E,Missotten L

更新日期：1984-10-01 00:00:00

abstract：:Sheep and goat pox continue to be important livestock diseases that pose a major threat to the livestock industry in many regions in Africa and Asia. Currently, several live attenuated vaccines are available and used in endemic countries to control these diseases. One of these is a partially attenuated strain of lumpy...

journal_title：Antiviral research

authors： Boshra H,Truong T,Nfon C,Bowden TR,Gerdts V,Tikoo S,Babiuk LA,Kara P,Mather A,Wallace DB,Babiuk S

更新日期：2015-11-01 00:00:00

abstract：:Nucleoside analogues have been the most successful antiviral compounds. Likewise, they are the most intriguing antiviral compounds, because of their structural relationship to natural nucleosides. This is also the reason why the design process of a potential selective antiviral nucleoside is so difficult. Too many nat...

journal_title：Antiviral research

authors： Herdewijn P

更新日期：2006-09-01 00:00:00

abstract：:Isolation of rhinoviruses from nasal secretions may be delayed or prevented by exogenously applied interferon which is carried over into nasal wash specimens. In studies of interferon-alpha 2 treated volunteers with experimental rhinovirus infection, we determined that incorporation of antiinterferon antibody into col...

journal_title：Antiviral research

authors： Hayden FG,Gwaltney JM Jr

更新日期：1983-03-01 00:00:00

abstract：:The heterocycle, 4,6-dibenzamidopyrazolo[3,4-d]pyrimidine (DBAPP), inhibited cytopathology induced by human, mouse, and vervet monkey cytomegaloviruses (CMV) in vitro at 0.2 to 0.5 microM, but did not inhibit cell replication at less than or equal to 30 microM. Herpes simplex viruses were unaffected by the inhibitor. ...

journal_title：Antiviral research

authors： Smee DF,Bartlett ML,Alaghamandan HA,Jones MM,Revankar GR,Robins RK

更新日期：1990-01-01 00:00:00

abstract：:Anti-herpes simplex virus (HSV) activities of oxyresveratrol in vitro and topical administration in cutaneous HSV-1 infection in mice were examined. The inhibitory concentrations for 50% plaque formation (IC(50)) of oxyresveratrol against HSV-1 clinical isolates and HSV-2 clinical isolates were 20.9-29.5 and 22.2-27.5...

journal_title：Antiviral research

authors： Lipipun V,Sasivimolphan P,Yoshida Y,Daikoku T,Sritularak B,Ritthidej G,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2011-08-01 00:00:00

abstract：:Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in b...

journal_title：Antiviral research

authors： Zhu HY,Han L,Shi XL,Wang BL,Huang H,Wang X,Chen DF,Ju DW,Feng MQ

更新日期：2015-01-01 00:00:00

abstract：:We have investigated the inhibitory effect of trans-cinnamaldehyde (CA), one of the principal constituents of essential oil derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. When 1-h drug treatment was initiated at various times post-infection (p.i.) in Madin-Darby canine kid...

journal_title：Antiviral research

authors： Hayashi K,Imanishi N,Kashiwayama Y,Kawano A,Terasawa K,Shimada Y,Ochiai H

更新日期：2007-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, invariably fatal neurologic disorder resulting from upper and lower motor neuron degeneration, which typically develops during the sixth or seventh decade of life, and is diagnosed based on standard clinical criteria. Its underlying cause remains undetermined. The ...

journal_title：Antiviral research

authors： Alfahad T,Nath A

更新日期：2013-08-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) has a poor prognosis owing to its intrinsic resistance to chemotherapy. Although zidovudine (AZT) and alpha interferon (IFN-alpha) give rise to some response and improve the prognosis of ATLL, alternative therapies are nee...

journal_title：Antiviral research

authors： Heraud JM,Mortreux F,Merien F,Contamin H,Mahieux R,Pouliquen JF,Wattel E,Gessain A,de Thé H,Bazarbachi A,Hermine O,Kazanji M

更新日期：2006-07-01 00:00:00