Abstract：
:The effects of caps, dinucleotides, oligonucleotides and polynucleotides on influenza virus RNA polymerase activity have been investigated. The results show that both methyl groups in a cap are necessary for optimal stimulation of polymerase activity. Both m7G(5')ppp(5')Am and ApG stimulated the influenza RNA polymerase activity and seemed to interact at different sites. Out of the 16 homopolynucleotides tested, seven inhibited influenza RNA polymerase by 50% at 2-10 micrograms/ml. Poly(G) gave a 90% reduction of influenza virus plaque formation at 10 micrograms/ml. An oligodeoxyribonucleotide complementary to the 12 terminal nucleotides of the 3' end of influenza virus RNA was synthesized. This oligonucleotide did not selectively inhibit influenza RNA polymerase.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Stridh S,Oberg B,Chattopadhyaya J,Josephson Sdoi
10.1016/0166-3542(81)90036-xsubject
Has Abstractpub_date
1981-06-01 00:00:00pages
97-105issue
2eissn
0166-3542issn
1872-9096pii
0166-3542(81)90036-Xjournal_volume
1pub_type
杂志文章abstract：:Influenza virus continues to remain one of the leading human respiratory pathogens causing significant morbidity and mortality around the globe. Due to short-term life cycle and high rate of mutations influenza virus is able to rapidly develop resistance to clinically available antivirals. This makes necessary the sea...
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abstract：:MicroRNA-122 (miR-122) is involved in the pathogenesis of several liver diseases, including chronic hepatitis B infection and hepatocellular carcinoma. This study aimed to explore the potential role of miR-122 in the interferon (IFN)-mediated suppression of hepatitis B virus (HBV) in hepatocytes. We found that elevate...
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journal_title：Antiviral research
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journal_title：Antiviral research
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pub_type： 杂志文章
doi：10.1016/0166-3542(93)90032-e
更新日期：1993-07-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2010.10.009
更新日期：2011-01-01 00:00:00
abstract：:The 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT)-like compounds with homocyclic moieties at the N-1 of the pyrimidinedione, including the highly potent lead compound IQP-0410, inhibit HIV-1 at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism involving allosteric inhibition at...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.09.005
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.12.003
更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.antiviral.2017.03.023
更新日期：2017-07-01 00:00:00
abstract：:On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons who required hospitalization and one who died. ADHSS and CDC condu...
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更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
abstract：:Emergence of drug-resistant human cytomegalovirus (HCMV) strains is a substantial problem during treatment of HCMV infections in immunocompromised patients. The Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) were previously shown to be potent inhibitors of AD169 and Town...
journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
abstract：:Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mort...
journal_title：Antiviral research
pub_type： 历史文章,杂志文章,评审
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更新日期：2016-02-01 00:00:00
