Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants.

abstract：:In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A54...

journal_title：Antiviral research

authors： Zhiqiang W,Yaowu Y,Fan Y,Jian Y,Yongfeng H,Lina Z,Jianwei W,Qi J

更新日期：2010-03-01 00:00:00

abstract：:Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice...

journal_title：Antiviral research

authors： Guillemard E,Geniteau-Legendre M,Kergot R,Lemaire G,Petit JF,Labarre C,Quero AM

更新日期：1995-10-01 00:00:00

abstract：:The hepatitis B virus nucleocapsid or core antigen is extremely immunogenic during infection and after immunization. This review summarizes several features of the nucleocapsid which explain this exceptionally high immunogenicity: a unique three-dimensional folding, the presence of a region that interacts with immunog...

journal_title：Antiviral research

authors： Vanlandschoot P,Cao T,Leroux-Roels G

更新日期：2003-10-01 00:00:00

abstract：:The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels of anti-H1N1 antibodies at day30 after vaccination, higher reactivity was observed in AV at day180. While AV indu...

journal_title：Antiviral research

authors： Giarola-Silva S,Coelho-Dos-Reis JGA,Mourão MM,Campi-Azevedo AC,Nakagaki Silva EE,Luiza-Silva M,Martins MA,Silveira-Cassette ACO,Batista MA,Peruhype-Magalhães V,Antonelli LRDV,Leite Ribeiro JG,Elói-Santos SM,Machado AV,Teixeir

更新日期：2017-08-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the de novo biosynthesis of guanine nucleotide, namely, the conversion of IMP to XMP. The depletion of the intracellular GTP and dGTP pools is the major event occurring in the cells exposed to the inhibitors such as mycophenolic acid. The prese...

journal_title：Antiviral research

authors： Khan M,Dhanwani R,Patro IK,Rao PV,Parida MM

更新日期：2011-01-01 00:00:00

abstract：:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for ca...

journal_title：Antiviral research

authors： Tuppurainen ES,Pearson CR,Bachanek-Bankowska K,Knowles NJ,Amareen S,Frost L,Henstock MR,Lamien CE,Diallo A,Mertens PP

更新日期：2014-09-01 00:00:00

abstract：:The biological response modifier 7-thia-8-oxoguanosine was evaluated in mice against the hepatotropic Adames strain of Punta Toro virus. When administered intraperitoneally in divided doses, significant protection from death was conferred at doses of 50 and 100 mg/kg/day given 24 and 17 h pre-virus inoculation, 25-100...

journal_title：Antiviral research

authors： Smee DF,Huffman JH,Gessaman AC,Huggins JW,Sidwell RW

更新日期：1991-03-01 00:00:00

abstract：:We have analyzed a panel of protein kinase inhibitors (PKIs) and found that some indolocarbazoles (Gö6976, K252a, K252c) proved to be highly effective inhibitors of GCV-sensitive and -resistant human cytomegalovirus (HCMV) strains, but did not show any effect against herpes simplex virus. Antiviral activity was determ...

journal_title：Antiviral research

authors： Zimmermann A,Wilts H,Lenhardt M,Hahn M,Mertens T

更新日期：2000-10-01 00:00:00

abstract：:Resveratrol (RV), a polyphenolic natural product present in many plants and fruits, exhibits anti-inflammatory, cardio-protective and anti-proliferative properties. Moreover, RV affects a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering...

journal_title：Antiviral research

authors： De Leo A,Arena G,Lacanna E,Oliviero G,Colavita F,Mattia E

更新日期：2012-11-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00

abstract：:Influenza viruses (IV) continue to pose an imminent threat to human welfare. Yearly re-occurring seasonal epidemic outbreaks and pandemics with high mortality can occur. Besides vaccination against a limited number of viral strains only a few antiviral drugs are available, which are losing their effectiveness as more ...

journal_title：Antiviral research

authors： Haasbach E,Müller C,Ehrhardt C,Schreiber A,Pleschka S,Ludwig S,Planz O

更新日期：2017-06-01 00:00:00

abstract：:End stage liver disease caused by chronic infection with the hepatitis C virus (HCV) is a leading indication for liver transplantation, yet outcomes are poor since the liver graft is rapidly re-infected by HCV. Antibodies against the essential HCV receptor CD81 have been shown to inhibit HCV cell entry in vitro and in...

journal_title：Antiviral research

authors： Deest M,Westhaus S,Steinmann E,Manns MP,von Hahn T,Ciesek S

更新日期：2014-01-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) remain prevalent even with widespread use of combination antiretroviral therapy (ART), suggesting a potential role for co-morbidities in neurologic decline. Indeed, it is well established that ART drugs, particularly HIV protease inhibitors, can induce hyperlipidemia, lip...

journal_title：Antiviral research

authors： Gupta S,Knight AG,Losso BY,Ingram DK,Keller JN,Bruce-Keller AJ

更新日期：2012-07-01 00:00:00

abstract：:There is a pressing need for new vaccines against alphaviruses, which can cause fatal encephalitis (Venezuelan equine encephalitis virus (VEEV) and others) and severe arthralgia (e.g. Chikungunya virus, CHIKV). These positive-strand RNA viruses are diverse and evolve rapidly, meaning that the sequence of any vaccine s...

journal_title：Antiviral research

authors： Baker WS,Negi S,Braun W,Schein CH

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Lactoferrin (LF) is a glycoprotein present in human milk with known antimicrobial effects. In vitro, LF has demonstrated antiviral activity against respiratory syncytial virus (RSV). We sought to assess the effect of bovine (b)LF in RSV replication, lung inflammation and function, cytokine profiles and clini...

journal_title：Antiviral research

authors： Gualdi L,Mertz S,Gomez AM,Ramilo O,Wittke A,Mejias A

更新日期：2013-08-01 00:00:00

abstract：:Treatment of the chronic hepatitis C virus (HCV) infection is an unmet medical need, and the HCV NS3 serine protease (NS3-SP) has been used as an attractive target of antiviral screening against HCV. To find naturally chemical entities as lead compounds from which novel anti-HCV agents could be developed, bioassay-gui...

journal_title：Antiviral research

authors： Zuo G,Li Z,Chen L,Xu X

更新日期：2007-10-01 00:00:00

abstract：:Stilbenoids including resveratrol contain the basic structural unit of 1,2-diphenylethylene. Naturally occurring stilbenoids have broad structural features due to oligomerization and modifications and some have demonstrated potent biological activities. In an effort to identify bioactive stilbenoids, we screened a gro...

journal_title：Antiviral research

authors： Chen X,Qiao H,Liu T,Yang Z,Xu L,Xu Y,Ge HM,Tan RX,Li E

更新日期：2012-07-01 00:00:00

abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...

journal_title：Antiviral research

authors： Essey RJ,McDougall BR,Robinson WE Jr

更新日期：2001-09-01 00:00:00

abstract：:Introduction of segmented genomes into virion is an important process in viral replication of rotavirus. We previously studied the assortment of the VP7 gene segment (encoding outer capsid protein VP7) in the genetic background of simian rotavirus SA11 (G serotype 3, G3) and found the preferential selection of homolog...

journal_title：Antiviral research

authors： Okada J,Kobayashi N,Taniguchi K,Urasawa S

更新日期：1998-04-01 00:00:00

abstract：:Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded R...

journal_title：Antiviral research

authors： Prasanth KR,Hirano M,Fagg WS,McAnarney ET,Shan C,Xie X,Hage A,Pietzsch CA,Bukreyev A,Rajsbaum R,Shi PY,Bedford MT,Bradrick SS,Menachery V,Garcia-Blanco MA

更新日期：2020-10-01 00:00:00

abstract：:Distamycin-A hydrochloride, a synthetic antibiotic, and 2,3-dihydroxy-6-bromo-pyrazino (2,3-beta) pyrazine derivative, were used against tomato spotted wilt virus (TSWV) in tobacco plants. The drugs were applied to the leaves at concentrations of 200 and 400 mg/l. The results showed that both drugs delayed virus sprea...

journal_title：Antiviral research

authors： De Fazio G,Kudamatsu M

更新日期：1983-08-01 00:00:00

abstract：:Desferrioxamine (DFO) is commonly used in therapy as a chelator of ferric ion in disorders of iron overload. We found that DFO inhibits human cytomegalovirus (HCMV) replication in infected cultures of human foreskin fibroblasts (HFF) at concentrations that have been achieved in humans with no significant adverse effec...

journal_title：Antiviral research

authors： Cinatl J Jr,Cinatl J,Rabenau H,Gümbel HO,Kornhuber B,Doerr HW

更新日期：1994-09-01 00:00:00

abstract：:Herpesviruses encode a protease that is essential for virus replication. The protease undergoes cleavage to a processed form during capsid maturation. A recombinant 75 kDa form of the protease from human cytomegalovirus was purified and compared with the recombinant 29 kDa processed form. Modification with an active s...

journal_title：Antiviral research

authors： Wittwer AJ,Funckes-Shippy CL,Hippenmeyer PJ

更新日期：2002-08-01 00:00:00

abstract：:Schefflera heptaphylla is a popular medicinal plant in southern China. Three caffeoylquinic acid derivatives, namely 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 3-O-caffeoylquinic acid, were isolated from this plant and investigated for their antiviral activity against respiratory syncytial virus (...

journal_title：Antiviral research

authors： Li Y,But PP,Ooi VE

更新日期：2005-10-01 00:00:00

abstract：:Knowledge of drug protein-binding and blood cell partitioning may be important for evaluating the pharmacokinetic parameters of zidovudine, particularly because of its intracellular site of action and potential to induce side effects. Equilibrium dialysis studies of zidovudine were performed over 2 h to identify the e...

journal_title：Antiviral research

authors： Luzier A,Morse GD

更新日期：1993-07-01 00:00:00

abstract：:Murine cytomegalovirus (MCMV) neither induces a viral thymidine kinase (TK) nor enhances the activity of a cellular TK. Nevertheless, MCMV is highly susceptible to 9-(2-hydroxyethoxymethyl)guanine (acyclovir, ACV). The cellular TK is neither responsible for phosphorylation of ACV nor its anti-MCMV activity. This is cl...

journal_title：Antiviral research

authors： Ochiai H,Kumura K,Minamishima Y

更新日期：1992-01-01 00:00:00

abstract：:Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne flavivirus, is associated with increased risk of microcephaly in newborns and Guillain-Barré syndrome and other complications in adults. Cu...

journal_title：Antiviral research

authors： Li Z,Sakamuru S,Huang R,Brecher M,Koetzner CA,Zhang J,Chen H,Qin CF,Zhang QY,Zhou J,Kramer LD,Xia M,Li H

更新日期：2018-02-01 00:00:00

abstract：:Buffalopox virus, a zoonotic Indian vaccinia-like virus, is responsible for contagious disease affecting mainly buffaloes, cattle and humans. H3L gene, encoding for an immunodominant major envelope protein of intracellular mature virion of orthopoxviruses, is highly conserved and found to elicit neutralizing antibodie...

journal_title：Antiviral research

authors： Kumar A,Yogisharadhya R,Venkatesan G,Bhanuprakash V,Shivachandra SB

更新日期：2016-02-01 00:00:00

abstract：:Antiviral medication is used for the treatment of severe influenza infections, of which the neuraminidase inhibitors (NAIs) are the most effective drugs, approved so far. Here, we investigated the antiviral efficacy of the peptidomimetic furin inhibitor MI-701 in combination with oseltamivir carboxylate and ribavirin ...

journal_title：Antiviral research

authors： Lu Y,Hardes K,Dahms SO,Böttcher-Friebertshäuser E,Steinmetzer T,Than ME,Klenk HD,Garten W

更新日期：2015-08-01 00:00:00

abstract：:In vitro studies of HBV core promoter mutations in hepatoma cell lines suggest that some mutations in core promoter transcription factor binding sites result in reduced core promoter activity and viral replication. We sought to validate this hypothesis using clinical samples with viral load differences before and afte...

journal_title：Antiviral research

authors： Cheng Y,Seet BL,Ong CS,Wasser S,Tan TM,Peter FJ,Lim SG

更新日期：2006-03-01 00:00:00