Abstract:
:Stilbenoids including resveratrol contain the basic structural unit of 1,2-diphenylethylene. Naturally occurring stilbenoids have broad structural features due to oligomerization and modifications and some have demonstrated potent biological activities. In an effort to identify bioactive stilbenoids, we screened a group of dimeric and oligomeric stilbenoids against HSV-1 and HSV-2 infection. Several trimeric and tetrameric derivatives showed anti-herpetic activity at single digit micromolar concentrations. HSV-1 and HSV-2 replication requires for NF-κB and MAPK activation. The compounds showed no inhibitory activity against NF-κB and Erk/MAPK activation, instead those compounds promoted rapid and transient release of reactive oxygen species (ROS). Addition of N-acetylcysteine (NAC), a scavenger of ROS, reversed the inhibitory effect of those compounds against HSV replication. In addition to the identification of resveratrol derivatives with potent anti-HSV activity, our results uncover a mechanism of polyphenol-mediated anti-HSV response, linking anti-herpetic activity of oligomeric stilbenoids to innate immunity.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Chen X,Qiao H,Liu T,Yang Z,Xu L,Xu Y,Ge HM,Tan RX,Li Edoi
10.1016/j.antiviral.2012.05.001subject
Has Abstractpub_date
2012-07-01 00:00:00pages
30-6issue
1eissn
0166-3542issn
1872-9096pii
S0166-3542(12)00105-2journal_volume
95pub_type
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journal_title:Antiviral research
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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